Two sample MR report
X-11315 against Amyotrophic lateral sclerosis || id:ieu-a-1085
Date: 03 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | -0.0151114 | 0.3008555 | 0.9680507 |
| Weighted median | 3 | -0.2268581 | 0.1094698 | 0.0382342 |
| Inverse variance weighted | 3 | -0.2239540 | 0.0955652 | 0.0191055 |
| Simple mode | 3 | -0.2775276 | 0.1401636 | 0.1862489 |
| Weighted mode | 3 | -0.1807755 | 0.1265815 | 0.2894384 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0018165 | 1 | 0.9660043 |
| Inverse variance weighted | 0.5377530 | 2 | 0.7642376 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0077815 | 0.0106294 | 0.5977001 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001178 | 0 | TRUE | 0.4176176 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
