Two sample MR report
Histidine against Amyotrophic lateral sclerosis || id:ieu-a-1085
Date: 03 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 4 | 0.2260377 | 0.1337259 | 0.2330355 |
| Weighted median | 4 | -0.0922457 | 0.0295968 | 0.0018286 |
| Inverse variance weighted | 4 | -0.0671624 | 0.0285231 | 0.0185394 |
| Simple mode | 4 | -0.1014960 | 0.0436143 | 0.1024160 |
| Weighted mode | 4 | -0.1011682 | 0.0468956 | 0.1198795 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.1408367 | 2 | 0.9320038 |
| Inverse variance weighted | 5.0807947 | 3 | 0.1659757 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0260874 | 0.0117373 | 0.1563094 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 3.36e-05 | 1e-07 | TRUE | 0.5333698 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
