Two sample MR report
Hippurate levels against Amyotrophic lateral sclerosis || id:ieu-a-1085
Date: 03 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 8 | -0.1128132 | 0.0543878 | 0.0833971 |
| Weighted median | 8 | -0.0566398 | 0.0224730 | 0.0117240 |
| Inverse variance weighted | 8 | -0.0543205 | 0.0168843 | 0.0012944 |
| Simple mode | 8 | -0.0827337 | 0.0367038 | 0.0588420 |
| Weighted mode | 8 | -0.0827337 | 0.0350526 | 0.0503212 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 5.528949 | 6 | 0.4779648 |
| Inverse variance weighted | 6.808956 | 7 | 0.4490388 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.006229 | 0.0055057 | 0.301081 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 6.03e-05 | 0 | TRUE | 0.5363859 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
