Two sample MR report
EDTA levels against Amyotrophic lateral sclerosis || id:ieu-a-1085
Date: 03 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | 0.0297486 | 0.0597707 | 0.6448059 |
| Weighted median | 6 | 0.0514530 | 0.0252902 | 0.0419007 |
| Inverse variance weighted | 6 | 0.0469049 | 0.0201609 | 0.0199908 |
| Simple mode | 6 | 0.0640466 | 0.0382889 | 0.1552419 |
| Weighted mode | 6 | 0.0640466 | 0.0374737 | 0.1481271 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 2.027558 | 4 | 0.7306901 |
| Inverse variance weighted | 2.120524 | 5 | 0.8322295 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0017915 | 0.0058756 | 0.7756458 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 4.44e-05 | 0 | TRUE | 0.5911345 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
