

# Two sample MR report

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## UKB-b-2618 against EBI-a-GCST005527

Date: **24 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|     b|   se|  pval|
|:-------------------------|----:|-----:|----:|-----:|
|MR Egger                  |    5| 4.330| 8.43| 0.643|
|Weighted median           |    5| 4.440| 1.72| 0.010|
|Inverse variance weighted |    5| 4.748| 1.79| 0.008|
|Simple mode               |    5| 0.006| 3.06| 0.999|
|Weighted mode             |    5| 3.857| 1.92| 0.115|

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### Heterogeneity tests


|method                    |    Q| Q_df| Q_pval|
|:-------------------------|----:|----:|------:|
|MR Egger                  | 8.47|    3|  0.037|
|Inverse variance weighted | 8.48|    4|  0.076|

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### Test for directional horizontal pleiotropy


| egger_intercept|    se|  pval|
|---------------:|-----:|-----:|
|           0.007| 0.141| 0.962|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|               0|              0|TRUE                     |        0.927|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/UKBb2618_against_EBIaGCST005527chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/UKBb2618_against_EBIaGCST005527chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/UKBb2618_against_EBIaGCST005527chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/UKBb2618_against_EBIaGCST005527chunk8-1.png)
