Two sample MR report
UKB-b-12417 against UKB-b-10537
Date: 24 February, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 320 | 0.017 | 0.009 | 0.063 |
| Weighted median | 320 | 0.002 | 0.002 | 0.458 |
| Inverse variance weighted | 320 | 0.005 | 0.002 | 0.006 |
| Simple mode | 320 | -0.009 | 0.008 | 0.297 |
| Weighted mode | 320 | -0.008 | 0.007 | 0.276 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 550 | 318 | 0 |
| Inverse variance weighted | 553 | 319 | 0 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0 | 0 | 0.188 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.8 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
