Two sample MR report
UKB-b-12417 against ukb-a-100
Date: 23 February, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 245 | 0.012 | 0.006 | 0.041 |
| Weighted median | 245 | 0.004 | 0.003 | 0.152 |
| Inverse variance weighted | 245 | 0.006 | 0.002 | 0.007 |
| Simple mode | 245 | -0.004 | 0.010 | 0.675 |
| Weighted mode | 245 | -0.005 | 0.009 | 0.593 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 427 | 243 | 0 |
| Inverse variance weighted | 429 | 244 | 0 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0 | 0 | 0.29 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.463 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
