Two sample MR report
UKB-b-2618 against EBI-a-GCST005527
Date: 24 February, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 5 | 4.330 | 8.43 | 0.643 |
| Weighted median | 5 | 4.440 | 1.72 | 0.010 |
| Inverse variance weighted | 5 | 4.748 | 1.79 | 0.008 |
| Simple mode | 5 | 0.006 | 3.06 | 0.999 |
| Weighted mode | 5 | 3.857 | 1.92 | 0.115 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 8.47 | 3 | 0.037 |
| Inverse variance weighted | 8.48 | 4 | 0.076 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.007 | 0.141 | 0.962 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.927 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
