Two sample MR report
UKB-b-9942 against UKB-b-10537
Date: 23 February, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 181 | 0.024 | 0.013 | 0.066 |
| Weighted median | 181 | 0.004 | 0.003 | 0.194 |
| Inverse variance weighted | 181 | 0.007 | 0.003 | 0.013 |
| Simple mode | 181 | 0.006 | 0.008 | 0.491 |
| Weighted mode | 181 | 0.004 | 0.008 | 0.631 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 429 | 179 | 0 |
| Inverse variance weighted | 433 | 180 | 0 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0 | 0 | 0.179 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.901 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
