Two sample MR report
ebi-a-GCST90038681 against ebi-a-GCST90018687
Date: 23 February, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 12 | 70.7 | 33.6 | 0.062 |
| Weighted median | 12 | 68.7 | 27.1 | 0.011 |
| Inverse variance weighted | 12 | 68.6 | 19.5 | 0.000 |
| Simple mode | 12 | 67.7 | 46.4 | 0.172 |
| Weighted mode | 12 | 12.5 | 36.9 | 0.741 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 21.3 | 10 | 0.019 |
| Inverse variance weighted | 21.3 | 11 | 0.030 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.007 | 0.084 | 0.939 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.001 | 0 | TRUE | 0 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
