Two sample MR report
39S ribosomal protein L34, mitochondrial against Interstitial lung disease || id:ebi-a-GCST90018643
Date: 07 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 5 | -0.3643056 | 1.4976503 | 0.8234949 |
| Weighted median | 5 | -0.5933584 | 0.2620491 | 0.0235555 |
| Inverse variance weighted | 5 | -0.5839645 | 0.2195341 | 0.0078137 |
| Simple mode | 5 | -0.6112857 | 0.3398377 | 0.1464500 |
| Weighted mode | 5 | -0.6143782 | 0.2871296 | 0.0991185 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.4754268 | 3 | 0.9242559 |
| Inverse variance weighted | 0.4974110 | 4 | 0.9737525 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0428384 | 0.2889201 | 0.8915345 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0003813 | 0 | TRUE | 0.2670374 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
