Two sample MR report
39S ribosomal protein L52, mitochondrial against Interstitial lung disease || id:ebi-a-GCST90018643
Date: 07 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 8 | -0.5044969 | 0.6152595 | 0.4435773 |
| Weighted median | 8 | -0.3544326 | 0.1823314 | 0.0519084 |
| Inverse variance weighted | 8 | -0.3473534 | 0.1364688 | 0.0109186 |
| Simple mode | 8 | -0.6522658 | 0.2686668 | 0.0455683 |
| Weighted mode | 8 | -0.3823130 | 0.2456381 | 0.1635659 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 5.481473 | 6 | 0.4836987 |
| Inverse variance weighted | 5.550083 | 7 | 0.5931500 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0307674 | 0.1174621 | 0.8021321 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0003518 | 0 | TRUE | 0.2865974 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
