

# Two sample MR report

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## SIRPB1_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    7|  0.0080449| 0.0464124| 0.8691864|
|Weighted median           |    7| -0.0213028| 0.0097007| 0.0280912|
|Inverse variance weighted |    7| -0.0277347| 0.0073920| 0.0001754|
|Simple mode               |    7| -0.0178055| 0.0160469| 0.3096545|
|Weighted mode             |    7| -0.0172935| 0.0136376| 0.2517529|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 5.091240|    5| 0.4048470|
|Inverse variance weighted | 5.712427|    6| 0.4561625|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0239245| 0.0306308| 0.4701134|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0004572|              0|TRUE                     |    0.0426454|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/SIRPB1Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/SIRPB1Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/SIRPB1Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/SIRPB1Macrophages_against_UKBb18436chunk8-1.png)
