

# Two sample MR report

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## SLC25A13_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3| -0.0060321| 0.2542558| 0.9848994|
|Weighted median           |    3|  0.0339571| 0.0168730| 0.0441657|
|Inverse variance weighted |    3|  0.0344175| 0.0144163| 0.0169676|
|Simple mode               |    3|  0.0335330| 0.0196347| 0.2297892|
|Weighted mode             |    3|  0.0333778| 0.0194448| 0.2282002|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0046500|    1| 0.9456338|
|Inverse variance weighted | 0.0300413|    2| 0.9850916|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0204053| 0.1280564| 0.8994026|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        5.24e-05|              0|TRUE                     |    0.4933522|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/SLC25A13Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/SLC25A13Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/SLC25A13Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/SLC25A13Macrophages_against_UKBb18436chunk8-1.png)
