

# Two sample MR report

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## HLA-DQA2_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |  122| -0.0058010| 0.0056231| 0.3043178|
|Weighted median           |  122|  0.0121123| 0.0014783| 0.0000000|
|Inverse variance weighted |  122|  0.0087864| 0.0012347| 0.0000000|
|Simple mode               |  122|  0.0141824| 0.0038628| 0.0003601|
|Weighted mode             |  122|  0.0136860| 0.0034678| 0.0001335|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 181.4470|  120| 0.0002498|
|Inverse variance weighted | 192.1125|  121| 0.0000413|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0193124| 0.0072716| 0.0089853|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0033774|          3e-07|TRUE                     |            0|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/HLADQA2Epithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/HLADQA2Epithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/HLADQA2Epithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/HLADQA2Epithelial_against_UKBb18436chunk8-1.png)
