

# Two sample MR report

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## HLA-DRB1_Endothelial Cell (Endo) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   16| -0.1049040| 0.0451125| 0.0355927|
|Weighted median           |   16|  0.0390177| 0.0123447| 0.0015740|
|Inverse variance weighted |   16|  0.0207218| 0.0086762| 0.0169237|
|Simple mode               |   16|  0.0445473| 0.0239233| 0.0822980|
|Weighted mode             |   16|  0.0442844| 0.0270379| 0.1222519|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  |  9.209056|   14| 0.8174297|
|Inverse variance weighted | 17.221871|   15| 0.3057749|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0555639| 0.0196291| 0.0133485|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0002211|              0|TRUE                     |    0.1597734|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/HLADRB1Endothelial_Cell_Endo_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/HLADRB1Endothelial_Cell_Endo_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/HLADRB1Endothelial_Cell_Endo_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/HLADRB1Endothelial_Cell_Endo_against_UKBb18436chunk8-1.png)
