

# Two sample MR report

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## PEX6_Epithelial against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   10|  0.1218258| 0.2036126| 0.5661755|
|Weighted median           |   10| -0.0266679| 0.0167761| 0.1119157|
|Inverse variance weighted |   10| -0.0289359| 0.0132646| 0.0291505|
|Simple mode               |   10| -0.0248695| 0.0216934| 0.2811901|
|Weighted mode             |   10| -0.0218513| 0.0196405| 0.2947292|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 4.284741|    8| 0.8305628|
|Inverse variance weighted | 4.835320|    9| 0.8484209|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0720315| 0.0970761| 0.4792968|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0002212|              0|TRUE                     |     0.157563|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/PEX6Epithelial_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/PEX6Epithelial_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/PEX6Epithelial_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/PEX6Epithelial_against_bbja88chunk8-1.png)
