

# Two sample MR report

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## FUOM_Monocyte (Mono) against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    5|  0.8631339| 0.7293942| 0.3218980|
|Weighted median           |    5| -0.0633213| 0.0515010| 0.2188788|
|Inverse variance weighted |    5| -0.0896820| 0.0391886| 0.0221100|
|Simple mode               |    5| -0.0466360| 0.0740716| 0.5631230|
|Weighted mode             |    5| -0.0458878| 0.0716614| 0.5567907|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.3970486|    3| 0.9408515|
|Inverse variance weighted | 2.1084379|    4| 0.7158224|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.5819386| 0.4448389| 0.2820121|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        3.84e-05|              0|TRUE                     |    0.5577439|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/FUOMMonocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/FUOMMonocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/FUOMMonocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/FUOMMonocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
