

# Two sample MR report

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## SAA1_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    3| 0.0847533| 0.3846177| 0.8619229|
|Weighted median           |    3| 0.0520640| 0.0284676| 0.0674169|
|Inverse variance weighted |    3| 0.0559366| 0.0237617| 0.0185696|
|Simple mode               |    3| 0.0488421| 0.0309108| 0.2548619|
|Weighted mode             |    3| 0.0490574| 0.0361004| 0.3071317|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.3365835|    1| 0.5618080|
|Inverse variance weighted | 0.3422185|    2| 0.8427295|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0092786| 0.1236049| 0.9523007|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|         3.4e-05|              0|TRUE                     |     0.581237|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/SAA1Epithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/SAA1Epithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/SAA1Epithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/SAA1Epithelial_against_UKBb18436chunk8-1.png)
