

# Two sample MR report

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## CPNE1_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   10| -0.0356789| 0.3172919| 0.9132383|
|Weighted median           |   10| -0.0719775| 0.0317944| 0.0235836|
|Inverse variance weighted |   10| -0.0669112| 0.0310625| 0.0312336|
|Simple mode               |   10| -0.1154876| 0.0508634| 0.0493193|
|Weighted mode             |   10| -0.0949827| 0.0475240| 0.0767228|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 17.58089|    8| 0.0245977|
|Inverse variance weighted | 17.60242|    9| 0.0400767|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0236685| 0.2391527| 0.9235985|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001379|              0|TRUE                     |    0.2678231|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/CPNE1Macrophages_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/CPNE1Macrophages_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/CPNE1Macrophages_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/CPNE1Macrophages_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
