

# Two sample MR report

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## CLEC12A_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   15| -0.1247409| 0.1078021| 0.2680398|
|Weighted median           |   15| -0.0544848| 0.0202417| 0.0071088|
|Inverse variance weighted |   15| -0.0317098| 0.0154884| 0.0406266|
|Simple mode               |   15| -0.0576241| 0.0336448| 0.1088123|
|Weighted mode             |   15| -0.0572493| 0.0317656| 0.0930726|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 6.150565|   13| 0.9405010|
|Inverse variance weighted | 6.910998|   14| 0.9380884|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0562093| 0.0644582| 0.3990127|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0006645|              0|TRUE                     |    0.0140991|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/CLEC12AMacrophages_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/CLEC12AMacrophages_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/CLEC12AMacrophages_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/CLEC12AMacrophages_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
