

# Two sample MR report

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## HLA-C_Dendritic Cell (DC) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   19|  0.0365857| 0.0432188| 0.4090201|
|Weighted median           |   19| -0.0143243| 0.0079303| 0.0708729|
|Inverse variance weighted |   19| -0.0154158| 0.0057923| 0.0077810|
|Simple mode               |   19| -0.0096250| 0.0167641| 0.5729753|
|Weighted mode             |   19| -0.0089795| 0.0185016| 0.6332912|

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### Heterogeneity tests


|method                    |       Q| Q_df|    Q_pval|
|:-------------------------|-------:|----:|---------:|
|MR Egger                  | 18.2563|   17| 0.3728472|
|Inverse variance weighted | 19.8387|   18| 0.3419734|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0314764| 0.0259303| 0.2413872|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0003209|              0|TRUE                     |    0.0895838|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/HLACDendritic_Cell_DC_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/HLACDendritic_Cell_DC_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/HLACDendritic_Cell_DC_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/HLACDendritic_Cell_DC_against_UKBb18436chunk8-1.png)
