

# Two sample MR report

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## ATPIF1_Epithelial against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    6|  0.2252866| 0.4578786| 0.6484836|
|Weighted median           |    6| -0.1096347| 0.0439916| 0.0126963|
|Inverse variance weighted |    6| -0.1076483| 0.0350340| 0.0021215|
|Simple mode               |    6| -0.1359728| 0.0543094| 0.0542463|
|Weighted mode             |    6| -0.1331964| 0.0593433| 0.0747904|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.2795924|    4| 0.9910932|
|Inverse variance weighted | 0.8114165|    5| 0.9762995|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|     pval|
|---------------:|---------:|--------:|
|      -0.1074182| 0.1472969| 0.506248|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        5.03e-05|              0|TRUE                     |    0.5018487|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/ATPIF1Epithelial_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/ATPIF1Epithelial_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/ATPIF1Epithelial_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/ATPIF1Epithelial_against_bbja88chunk8-1.png)
