

# Two sample MR report

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## HLA-DQB1_Dendritic Cell (DC) against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   16| -0.0305303| 0.1330509| 0.8218274|
|Weighted median           |   16| -0.0515999| 0.0212208| 0.0150334|
|Inverse variance weighted |   16| -0.0342717| 0.0169470| 0.0431470|
|Simple mode               |   16| -0.0554831| 0.0343337| 0.1269282|
|Weighted mode             |   16| -0.0546438| 0.0338626| 0.1274299|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 4.610080|   14| 0.9905338|
|Inverse variance weighted | 4.610883|   15| 0.9949397|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0020526| 0.0723981| 0.9777824|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0004431|              0|TRUE                     |    0.0451469|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/HLADQB1Dendritic_Cell_DC_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/HLADQB1Dendritic_Cell_DC_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/HLADQB1Dendritic_Cell_DC_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/HLADQB1Dendritic_Cell_DC_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
