

# Two sample MR report

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## MACROD2_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    6| -0.0382619| 0.0300957| 0.2725042|
|Weighted median           |    6| -0.0312143| 0.0095028| 0.0010207|
|Inverse variance weighted |    6| -0.0288579| 0.0076884| 0.0001744|
|Simple mode               |    6| -0.0312478| 0.0134939| 0.0684190|
|Weighted mode             |    6| -0.0312478| 0.0117723| 0.0451892|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.626154|    4| 0.8040840|
|Inverse variance weighted | 1.730609|    5| 0.8850212|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0073645| 0.0227866| 0.7627373|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        0.000144|              0|TRUE                     |    0.2558079|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/MACROD2Epithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/MACROD2Epithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/MACROD2Epithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/MACROD2Epithelial_against_UKBb18436chunk8-1.png)
