

# Two sample MR report

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## TBC1D20_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3| -0.0178031| 0.2241414| 0.9495405|
|Weighted median           |    3| -0.0427780| 0.0202519| 0.0346612|
|Inverse variance weighted |    3| -0.0457114| 0.0172416| 0.0080201|
|Simple mode               |    3| -0.0426918| 0.0234194| 0.2098888|
|Weighted mode             |    3| -0.0426682| 0.0238201| 0.2151283|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0579850|    1| 0.8097096|
|Inverse variance weighted | 0.0735805|    2| 0.9638783|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0251684| 0.2015377| 0.9209071|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        3.15e-05|              0|TRUE                     |    0.5951863|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/TBC1D20Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/TBC1D20Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/TBC1D20Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/TBC1D20Macrophages_against_UKBb18436chunk8-1.png)
