

# Two sample MR report

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## NRGN_Epithelial against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    4| -0.0693395| 0.1605680| 0.7079557|
|Weighted median           |    4|  0.0350021| 0.0136285| 0.0102200|
|Inverse variance weighted |    4|  0.0385323| 0.0113479| 0.0006849|
|Simple mode               |    4|  0.0355931| 0.0158792| 0.1108076|
|Weighted mode             |    4|  0.0352636| 0.0144090| 0.0918968|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.4029240|    2| 0.8175346|
|Inverse variance weighted | 0.8565241|    3| 0.8359048|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.1093958| 0.1624292| 0.5700334|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        7.39e-05|              0|TRUE                     |    0.4160083|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/NRGNEpithelial_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/NRGNEpithelial_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/NRGNEpithelial_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/NRGNEpithelial_against_bbja88chunk8-1.png)
