

# Two sample MR report

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## TMPRSS4_Dendritic Cell (DC) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    4|  0.0157180| 0.0986323| 0.8880245|
|Weighted median           |    4| -0.0251181| 0.0119312| 0.0352705|
|Inverse variance weighted |    4| -0.0233971| 0.0102510| 0.0224640|
|Simple mode               |    4| -0.0260573| 0.0158580| 0.1988919|
|Weighted mode             |    4| -0.0259805| 0.0156997| 0.1965310|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0100097|    2| 0.9950076|
|Inverse variance weighted | 0.1689988|    3| 0.9824316|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0428935| 0.1075742| 0.7286321|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        3.77e-05|              0|TRUE                     |    0.5599782|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/TMPRSS4Dendritic_Cell_DC_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/TMPRSS4Dendritic_Cell_DC_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/TMPRSS4Dendritic_Cell_DC_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/TMPRSS4Dendritic_Cell_DC_against_UKBb18436chunk8-1.png)
