

# Two sample MR report

---

## HLA-DQB1_T Proliferating against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

---

### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   14|  0.0981955| 0.2150202| 0.6560569|
|Weighted median           |   14| -0.0695834| 0.0293956| 0.0179261|
|Inverse variance weighted |   14| -0.0506185| 0.0234116| 0.0306098|
|Simple mode               |   14| -0.0728317| 0.0477461| 0.1511149|
|Weighted mode             |   14| -0.0721317| 0.0471702| 0.1501813|

---

### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 2.318694|   12| 0.9987378|
|Inverse variance weighted | 2.803433|   13| 0.9985552|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0633653| 0.0910118| 0.4995472|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0005176|              0|TRUE                     |    0.0303505|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/HLADQB1T_Proliferating_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/HLADQB1T_Proliferating_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/HLADQB1T_Proliferating_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/HLADQB1T_Proliferating_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
