

# Two sample MR report

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## NRP2_Alveolar Macrophages against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    6| 0.2015482| 0.1539161| 0.2605252|
|Weighted median           |    6| 0.0354100| 0.0140678| 0.0118327|
|Inverse variance weighted |    6| 0.0308704| 0.0113856| 0.0067011|
|Simple mode               |    6| 0.0414576| 0.0200223| 0.0931712|
|Weighted mode             |    6| 0.0416320| 0.0208507| 0.1023738|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.7052492|    4| 0.9506800|
|Inverse variance weighted | 1.9416778|    5| 0.8571548|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.1467394| 0.1319661| 0.3284845|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0002367|              0|TRUE                     |    0.1438877|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/NRP2Alveolar_Macrophages_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/NRP2Alveolar_Macrophages_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/NRP2Alveolar_Macrophages_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/NRP2Alveolar_Macrophages_against_bbja88chunk8-1.png)
