

# Two sample MR report

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## NAGK_Macrophages against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   15| -0.0942196| 0.0786579| 0.2523635|
|Weighted median           |   15| -0.0453420| 0.0134899| 0.0007761|
|Inverse variance weighted |   15| -0.0262387| 0.0108357| 0.0154566|
|Simple mode               |   15| -0.0556833| 0.0259641| 0.0500147|
|Weighted mode             |   15| -0.0542325| 0.0223709| 0.0294669|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 17.17500|   13| 0.1914273|
|Inverse variance weighted | 18.18125|   14| 0.1986500|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0387694| 0.0444234| 0.3986466|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0002861|              0|TRUE                     |    0.1086752|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/NAGKMacrophages_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/NAGKMacrophages_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/NAGKMacrophages_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/NAGKMacrophages_against_bbja88chunk8-1.png)
