

# Two sample MR report

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## IAH1_Alveolar Macrophages against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   16| -0.0361363| 0.2370965| 0.8810369|
|Weighted median           |   16|  0.0687422| 0.0198832| 0.0005456|
|Inverse variance weighted |   16|  0.0638781| 0.0149759| 0.0000200|
|Simple mode               |   16|  0.0858295| 0.0285159| 0.0087939|
|Weighted mode             |   16|  0.0584330| 0.0241912| 0.0289363|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 4.595731|   14| 0.9906820|
|Inverse variance weighted | 4.774384|   15| 0.9938704|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0602261| 0.1424882| 0.6789532|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0002514|              0|TRUE                     |    0.1322159|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/IAH1Alveolar_Macrophages_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/IAH1Alveolar_Macrophages_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/IAH1Alveolar_Macrophages_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/IAH1Alveolar_Macrophages_against_bbja88chunk8-1.png)
