

# Two sample MR report

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## SECISBP2L_Epithelial against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    6| -0.0066591| 0.2816514| 0.9822699|
|Weighted median           |    6| -0.0829837| 0.0374509| 0.0267051|
|Inverse variance weighted |    6| -0.0730588| 0.0300491| 0.0150440|
|Simple mode               |    6| -0.0843137| 0.0489276| 0.1454544|
|Weighted mode             |    6| -0.0825403| 0.0468786| 0.1385938|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.9574926|    4| 0.9161715|
|Inverse variance weighted | 1.0137113|    5| 0.9614523|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0381339| 0.1608314| 0.8242239|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        7.49e-05|              0|TRUE                     |    0.4114008|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/SECISBP2LEpithelial_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/SECISBP2LEpithelial_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/SECISBP2LEpithelial_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/SECISBP2LEpithelial_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
