

# Two sample MR report

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## SPATC1L_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3|  0.0224432| 0.0723413| 0.8084888|
|Weighted median           |    3| -0.0416752| 0.0152850| 0.0064003|
|Inverse variance weighted |    3| -0.0348639| 0.0123003| 0.0045912|
|Simple mode               |    3| -0.0446727| 0.0186572| 0.1389699|
|Weighted mode             |    3| -0.0446727| 0.0205298| 0.1615241|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.7755381|    1| 0.3785092|
|Inverse variance weighted | 1.4217656|    2| 0.4912104|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0424207| 0.0527698| 0.5689422|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        2.61e-05|              0|TRUE                     |    0.6309711|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/SPATC1LMacrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/SPATC1LMacrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/SPATC1LMacrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/SPATC1LMacrophages_against_UKBb18436chunk8-1.png)
