

# Two sample MR report

---

## HLA-DQB1_Endothelial Cell (Endo) against UKB-b-18436

Date: **13 January, 2026**

---

### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    5| 0.0713874| 0.1408794| 0.6472430|
|Weighted median           |    5| 0.0472383| 0.0151559| 0.0018281|
|Inverse variance weighted |    5| 0.0545864| 0.0115668| 0.0000024|
|Simple mode               |    5| 0.0447254| 0.0215199| 0.1062234|
|Weighted mode             |    5| 0.0436379| 0.0208193| 0.1041186|

---

### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.835395|    3| 0.6072631|
|Inverse variance weighted | 1.849714|    4| 0.7633755|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0083937| 0.0701453| 0.9123144|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        7.43e-05|              0|TRUE                     |    0.4220284|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/HLADQB1Endothelial_Cell_Endo_against_UKBb18436chunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/HLADQB1Endothelial_Cell_Endo_against_UKBb18436chunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/HLADQB1Endothelial_Cell_Endo_against_UKBb18436chunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/HLADQB1Endothelial_Cell_Endo_against_UKBb18436chunk8-1.png)
