

# Two sample MR report

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## SMDT1_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   11| -0.1966219| 0.1582313| 0.2454068|
|Weighted median           |   11| -0.0690255| 0.0269561| 0.0104471|
|Inverse variance weighted |   11| -0.0514305| 0.0219239| 0.0189831|
|Simple mode               |   11| -0.0710025| 0.0422044| 0.1234128|
|Weighted mode             |   11| -0.0699706| 0.0416294| 0.1237205|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.861891|    9| 0.9934680|
|Inverse variance weighted | 2.720342|   10| 0.9872613|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0657347| 0.0709475| 0.3783484|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0004211|              0|TRUE                     |    0.0508648|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/SMDT1Macrophages_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/SMDT1Macrophages_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/SMDT1Macrophages_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/SMDT1Macrophages_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
