

# Two sample MR report

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## SMIM19_Monocyte (Mono) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3|  0.7065136| 1.5944679| 0.7344636|
|Weighted median           |    3| -0.0476556| 0.0188786| 0.0115921|
|Inverse variance weighted |    3| -0.0460229| 0.0147826| 0.0018500|
|Simple mode               |    3| -0.0508280| 0.0214276| 0.1410674|
|Weighted mode             |    3| -0.0506372| 0.0216336| 0.1440942|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0126090|    1| 0.9105935|
|Inverse variance weighted | 0.2353812|    2| 0.8889711|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.3578503| 0.7581777| 0.7192587|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        3.68e-05|              0|TRUE                     |    0.5676858|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/SMIM19Monocyte_Mono_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/SMIM19Monocyte_Mono_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/SMIM19Monocyte_Mono_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/SMIM19Monocyte_Mono_against_UKBb18436chunk8-1.png)
