

# Two sample MR report

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## FAM3B_Dendritic Cell (DC) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3| -0.0879544| 0.0768017| 0.4569714|
|Weighted median           |    3| -0.0181272| 0.0091401| 0.0473380|
|Inverse variance weighted |    3| -0.0202607| 0.0069419| 0.0035157|
|Simple mode               |    3| -0.0169287| 0.0108506| 0.2590876|
|Weighted mode             |    3| -0.0162248| 0.0106592| 0.2673980|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.4333413|    1| 0.5103539|
|Inverse variance weighted | 1.2166221|    2| 0.5442693|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|        0.095286| 0.107664| 0.5387795|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        4.59e-05|              0|TRUE                     |    0.5224517|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/FAM3BDendritic_Cell_DC_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/FAM3BDendritic_Cell_DC_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/FAM3BDendritic_Cell_DC_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/FAM3BDendritic_Cell_DC_against_UKBb18436chunk8-1.png)
