

# Two sample MR report

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## TUFM_Dendritic Cell (DC) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   15| 0.1641481| 0.1122791| 0.1675007|
|Weighted median           |   15| 0.0517636| 0.0104652| 0.0000008|
|Inverse variance weighted |   15| 0.0451685| 0.0080603| 0.0000000|
|Simple mode               |   15| 0.0519813| 0.0151198| 0.0039993|
|Weighted mode             |   15| 0.0519813| 0.0158311| 0.0054379|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  |  9.925217|   13| 0.7000379|
|Inverse variance weighted | 11.053950|   14| 0.6817926|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0463197| 0.0435984| 0.3073841|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0002612|              0|TRUE                     |    0.1267925|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/TUFMDendritic_Cell_DC_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/TUFMDendritic_Cell_DC_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/TUFMDendritic_Cell_DC_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/TUFMDendritic_Cell_DC_against_UKBb18436chunk8-1.png)
