

# Two sample MR report

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## HLA-DOA_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    3| 0.0815674| 0.8346084| 0.9379793|
|Weighted median           |    3| 0.1272043| 0.0711974| 0.0739953|
|Inverse variance weighted |    3| 0.1293975| 0.0551374| 0.0189344|
|Simple mode               |    3| 0.1243320| 0.0793477| 0.2576441|
|Weighted mode             |    3| 0.1250009| 0.0770548| 0.2462175|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0337548|    1| 0.8542294|
|Inverse variance weighted | 0.0370534|    2| 0.9816438|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|        0.017878| 0.3112797| 0.9634766|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        1.86e-05|              0|TRUE                     |    0.6829261|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/HLADOAMacrophages_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/HLADOAMacrophages_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/HLADOAMacrophages_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/HLADOAMacrophages_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
