

# Two sample MR report

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## HLA-DPB1_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   17| 0.0007490| 0.0621961| 0.9905502|
|Weighted median           |   17| 0.0172871| 0.0081258| 0.0333842|
|Inverse variance weighted |   17| 0.0245415| 0.0061018| 0.0000577|
|Simple mode               |   17| 0.0159358| 0.0132308| 0.2459328|
|Weighted mode             |   17| 0.0154025| 0.0124856| 0.2351591|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 12.42374|   15| 0.6467133|
|Inverse variance weighted | 12.57150|   16| 0.7037919|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0126548| 0.0329216| 0.7060815|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0004529|              0|TRUE                     |    0.0439248|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/HLADPB1Epithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/HLADPB1Epithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/HLADPB1Epithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/HLADPB1Epithelial_against_UKBb18436chunk8-1.png)
