

# Two sample MR report

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## HLA-DQB1_Conventional Dendritic Cell against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   15|  0.0460197| 0.1390522| 0.7459539|
|Weighted median           |   15| -0.0438237| 0.0173567| 0.0115737|
|Inverse variance weighted |   15| -0.0340911| 0.0139919| 0.0148308|
|Simple mode               |   15| -0.0449124| 0.0282491| 0.1341848|
|Weighted mode             |   15| -0.0446742| 0.0288433| 0.1437199|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 2.418592|   13| 0.9993487|
|Inverse variance weighted | 2.753902|   14| 0.9994349|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0547734| 0.0945902| 0.5724466|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0004389|              0|TRUE                     |    0.0461864|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/HLADQB1Conventional_Dendritic_Cell_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/HLADQB1Conventional_Dendritic_Cell_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/HLADQB1Conventional_Dendritic_Cell_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/HLADQB1Conventional_Dendritic_Cell_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
