

# Two sample MR report

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## CDC42EP1_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   12| 0.0307262| 0.0294187| 0.3208703|
|Weighted median           |   12| 0.0166543| 0.0053724| 0.0019353|
|Inverse variance weighted |   12| 0.0159800| 0.0043095| 0.0002088|
|Simple mode               |   12| 0.0158011| 0.0082557| 0.0819895|
|Weighted mode             |   12| 0.0161616| 0.0077826| 0.0620568|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 2.918693|   10| 0.9832732|
|Inverse variance weighted | 3.175455|   11| 0.9881979|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0123581| 0.0243886| 0.6233386|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0005778|              0|TRUE                     |    0.0222581|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/CDC42EP1Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/CDC42EP1Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/CDC42EP1Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/CDC42EP1Macrophages_against_UKBb18436chunk8-1.png)
