

# Two sample MR report

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## UCHL3_Macrophages against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    6| -0.0567127| 0.1607021| 0.7419710|
|Weighted median           |    6| -0.0348677| 0.0173645| 0.0446439|
|Inverse variance weighted |    6| -0.0393058| 0.0138805| 0.0046296|
|Simple mode               |    6| -0.0342547| 0.0228581| 0.1942578|
|Weighted mode             |    6| -0.0333949| 0.0223869| 0.1959780|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.6482173|    4| 0.9575579|
|Inverse variance weighted | 0.6600381|    5| 0.9850897|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|        0.010303| 0.0947637| 0.9186575|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001101|              0|TRUE                     |    0.3199798|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/UCHL3Macrophages_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/UCHL3Macrophages_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/UCHL3Macrophages_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/UCHL3Macrophages_against_bbja88chunk8-1.png)
