

# Two sample MR report

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## SHTN1_Interstitial Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    3| 0.1459316| 0.2911861| 0.7042409|
|Weighted median           |    3| 0.0544340| 0.0155643| 0.0004699|
|Inverse variance weighted |    3| 0.0523612| 0.0131890| 0.0000718|
|Simple mode               |    3| 0.0548579| 0.0198034| 0.1093534|
|Weighted mode             |    3| 0.0548242| 0.0200825| 0.1120707|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0005300|    1| 0.9816323|
|Inverse variance weighted | 0.1040033|    2| 0.9493273|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0580795| 0.1805547| 0.8018716|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001042|              0|TRUE                     |      0.33782|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/SHTN1Interstitial_Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/SHTN1Interstitial_Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/SHTN1Interstitial_Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/SHTN1Interstitial_Macrophages_against_UKBb18436chunk8-1.png)
