

# Two sample MR report

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## CNKSR1_Epithelial against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    6|  0.0080020| 0.1608816| 0.9627152|
|Weighted median           |    6| -0.0536887| 0.0185256| 0.0037545|
|Inverse variance weighted |    6| -0.0539779| 0.0151221| 0.0003577|
|Simple mode               |    6| -0.0566133| 0.0236838| 0.0623586|
|Weighted mode             |    6| -0.0522828| 0.0212068| 0.0568516|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.1691618|    4| 0.9966185|
|Inverse variance weighted | 0.3189037|    5| 0.9972724|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|     pval|
|---------------:|---------:|--------:|
|      -0.0331919| 0.0857748| 0.718488|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001172|              0|TRUE                     |    0.3053281|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/CNKSR1Epithelial_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/CNKSR1Epithelial_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/CNKSR1Epithelial_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/CNKSR1Epithelial_against_bbja88chunk8-1.png)
