

# Two sample MR report

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## PLA2G16_Macrophages against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3|  0.1812806| 0.5941730| 0.8114799|
|Weighted median           |    3| -0.1043483| 0.0433313| 0.0160335|
|Inverse variance weighted |    3| -0.1057643| 0.0359500| 0.0032611|
|Simple mode               |    3| -0.1096733| 0.0521921| 0.1703848|
|Weighted mode             |    3| -0.0995235| 0.0505036| 0.1875606|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0039346|    1| 0.9499843|
|Inverse variance weighted | 0.2381777|    2| 0.8877289|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0812647| 0.1679068| 0.7130404|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        4.41e-05|              0|TRUE                     |    0.5308074|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/PLA2G16Macrophages_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/PLA2G16Macrophages_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/PLA2G16Macrophages_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/PLA2G16Macrophages_against_bbja88chunk8-1.png)
