

# Two sample MR report

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## CAT_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    7| -0.0627017| 0.0745754| 0.4388163|
|Weighted median           |    7|  0.0179096| 0.0108106| 0.0975861|
|Inverse variance weighted |    7|  0.0210902| 0.0080976| 0.0092007|
|Simple mode               |    7|  0.0236250| 0.0173613| 0.2224749|
|Weighted mode             |    7|  0.0167033| 0.0159139| 0.3343266|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 4.435015|    5| 0.4886250|
|Inverse variance weighted | 5.712520|    6| 0.4561516|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0509192| 0.0450506| 0.3096483|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0002457|              0|TRUE                     |    0.1366004|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/CATEpithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/CATEpithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/CATEpithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/CATEpithelial_against_UKBb18436chunk8-1.png)
