

# Two sample MR report

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## GRHPR_Monocyte (Mono) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3| -0.0448688| 0.1461277| 0.8103421|
|Weighted median           |    3|  0.0246279| 0.0127807| 0.0539843|
|Inverse variance weighted |    3|  0.0227155| 0.0109216| 0.0375378|
|Simple mode               |    3|  0.0268633| 0.0141718| 0.1984914|
|Weighted mode             |    3|  0.0268271| 0.0152590| 0.2208029|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0000001|    1| 0.9997370|
|Inverse variance weighted | 0.2151094|    2| 0.8980274|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0450252| 0.0970792| 0.7235354|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        3.24e-05|              0|TRUE                     |    0.5893376|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/GRHPRMonocyte_Mono_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/GRHPRMonocyte_Mono_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/GRHPRMonocyte_Mono_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/GRHPRMonocyte_Mono_against_UKBb18436chunk8-1.png)
