

# Two sample MR report

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## AKR1C3_Endothelial Cell (Endo) against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   11| -0.2790893| 0.1339303| 0.0668478|
|Weighted median           |   11|  0.0947073| 0.0254047| 0.0001931|
|Inverse variance weighted |   11|  0.0688513| 0.0232072| 0.0030091|
|Simple mode               |   11|  0.1220026| 0.0388024| 0.0104353|
|Weighted mode             |   11|  0.1169216| 0.0395900| 0.0144526|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  |  9.743545|    9| 0.3716429|
|Inverse variance weighted | 17.191165|   10| 0.0702396|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.3882258| 0.1480174| 0.0276818|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001204|              0|TRUE                     |    0.3004619|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/AKR1C3Endothelial_Cell_Endo_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/AKR1C3Endothelial_Cell_Endo_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/AKR1C3Endothelial_Cell_Endo_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/AKR1C3Endothelial_Cell_Endo_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
