

# Two sample MR report

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## CD52_Monocyte (Mono) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   17| 0.0421569| 0.0395087| 0.3028316|
|Weighted median           |   17| 0.0450720| 0.0090370| 0.0000006|
|Inverse variance weighted |   17| 0.0312592| 0.0078925| 0.0000748|
|Simple mode               |   17| 0.0504170| 0.0140588| 0.0024705|
|Weighted mode             |   17| 0.0493491| 0.0123285| 0.0010259|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 27.75639|   15| 0.0231447|
|Inverse variance weighted | 27.90340|   16| 0.0324699|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0064651| 0.0229368| 0.7818996|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0007001|              0|TRUE                     |    0.0121736|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/CD52Monocyte_Mono_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/CD52Monocyte_Mono_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/CD52Monocyte_Mono_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/CD52Monocyte_Mono_against_UKBb18436chunk8-1.png)
