

# Two sample MR report

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## PARK7_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   22|  0.0201572| 0.0285733| 0.4886622|
|Weighted median           |   22| -0.0218628| 0.0099225| 0.0275695|
|Inverse variance weighted |   22| -0.0248396| 0.0077619| 0.0013732|
|Simple mode               |   22| -0.0219537| 0.0169782| 0.2100374|
|Weighted mode             |   22| -0.0211946| 0.0165654| 0.2146948|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 2.059889|   20| 0.9999999|
|Inverse variance weighted | 4.737421|   21| 0.9999156|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0179404| 0.0109639| 0.1174136|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0002927|              0|TRUE                     |    0.1039533|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/PARK7Epithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/PARK7Epithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/PARK7Epithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/PARK7Epithelial_against_UKBb18436chunk8-1.png)
