

# Two sample MR report

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## ABRACL_Alveolar Macrophages against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    7|  0.0034858| 0.0793640| 0.9666670|
|Weighted median           |    7| -0.0361245| 0.0145180| 0.0128371|
|Inverse variance weighted |    7| -0.0342609| 0.0117327| 0.0034989|
|Simple mode               |    7| -0.0404160| 0.0212889| 0.1063974|
|Weighted mode             |    7| -0.0385516| 0.0199791| 0.1019020|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.182907|    5| 0.9465067|
|Inverse variance weighted | 1.414170|    6| 0.9649908|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0229711| 0.0477671| 0.6508945|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001205|              0|TRUE                     |    0.2980429|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/ABRACLAlveolar_Macrophages_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/ABRACLAlveolar_Macrophages_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/ABRACLAlveolar_Macrophages_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/ABRACLAlveolar_Macrophages_against_bbja88chunk8-1.png)
