

# Two sample MR report

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## ETFB_Epithelial against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3| -1.4583992| 1.7036437| 0.5492769|
|Weighted median           |    3|  0.0786002| 0.0370870| 0.0340613|
|Inverse variance weighted |    3|  0.0669727| 0.0298970| 0.0250835|
|Simple mode               |    3|  0.0898249| 0.0440300| 0.1781564|
|Weighted mode             |    3|  0.0898249| 0.0463411| 0.1921592|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.1012193|    1| 0.7503713|
|Inverse variance weighted | 0.9031331|    2| 0.6366300|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|     pval|
|---------------:|---------:|--------:|
|        0.553402| 0.6179835| 0.535063|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        1.85e-05|              0|TRUE                     |    0.6844011|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/ETFBEpithelial_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/ETFBEpithelial_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/ETFBEpithelial_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/ETFBEpithelial_against_bbja88chunk8-1.png)
