

# Two sample MR report

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## HLA-DQA2_Endothelial Cell (Endo) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   26| -0.0039026| 0.0122491| 0.7527861|
|Weighted median           |   26|  0.0146884| 0.0029221| 0.0000005|
|Inverse variance weighted |   26|  0.0119826| 0.0021089| 0.0000000|
|Simple mode               |   26|  0.0157551| 0.0046941| 0.0025266|
|Weighted mode             |   26|  0.0153789| 0.0050935| 0.0057642|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 21.89676|   24| 0.5854289|
|Inverse variance weighted | 23.62993|   25| 0.5408299|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0204832| 0.0155588| 0.2004409|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0003583|              0|TRUE                     |    0.0734014|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/HLADQA2Endothelial_Cell_Endo_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/HLADQA2Endothelial_Cell_Endo_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/HLADQA2Endothelial_Cell_Endo_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/HLADQA2Endothelial_Cell_Endo_against_UKBb18436chunk8-1.png)
