

# Two sample MR report

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## WBSCR27_Epithelial against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   15| -0.0303023| 0.0401143| 0.4634774|
|Weighted median           |   15|  0.0512832| 0.0101605| 0.0000004|
|Inverse variance weighted |   15|  0.0560956| 0.0084203| 0.0000000|
|Simple mode               |   15|  0.0505982| 0.0201463| 0.0249047|
|Weighted mode             |   15|  0.0457902| 0.0176178| 0.0210147|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 16.81387|   13| 0.2079531|
|Inverse variance weighted | 23.02892|   14| 0.0598007|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0646311| 0.0294837| 0.0471769|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0006252|          3e-07|TRUE                     |    0.0195131|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/WBSCR27Epithelial_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/WBSCR27Epithelial_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/WBSCR27Epithelial_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/WBSCR27Epithelial_against_bbja88chunk8-1.png)
