

# Two sample MR report

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## CHD1L_Alveolar Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   13|  0.0966838| 0.0723579| 0.2084716|
|Weighted median           |   13| -0.0165151| 0.0073103| 0.0238743|
|Inverse variance weighted |   13| -0.0126510| 0.0056079| 0.0240760|
|Simple mode               |   13| -0.0237020| 0.0128392| 0.0896850|
|Weighted mode             |   13| -0.0231324| 0.0130393| 0.1014079|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 5.015644|   11| 0.9304066|
|Inverse variance weighted | 7.312644|   12| 0.8362802|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       -0.069931| 0.0461413| 0.1578201|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001628|              0|TRUE                     |    0.2254415|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/CHD1LAlveolar_Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/CHD1LAlveolar_Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/CHD1LAlveolar_Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/CHD1LAlveolar_Macrophages_against_UKBb18436chunk8-1.png)
