

# Two sample MR report

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## TTLL10_Epithelial against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3|  0.2056235| 1.0876951| 0.8810538|
|Weighted median           |    3| -0.0720516| 0.0233854| 0.0020627|
|Inverse variance weighted |    3| -0.0721993| 0.0188921| 0.0001326|
|Simple mode               |    3| -0.0738332| 0.0284252| 0.1217378|
|Weighted mode             |    3| -0.0715700| 0.0282700| 0.1269779|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0256394|    1| 0.8727841|
|Inverse variance weighted | 0.0909003|    2| 0.9555673|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.1972434| 0.7721047| 0.8407733|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        3.76e-05|              0|TRUE                     |    0.5650857|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/TTLL10Epithelial_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/TTLL10Epithelial_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/TTLL10Epithelial_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/TTLL10Epithelial_against_bbja88chunk8-1.png)
