

# Two sample MR report

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## LGALS2_Conventional Dendritic Cell against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    4| 0.0283213| 0.2479720| 0.9195023|
|Weighted median           |    4| 0.0373828| 0.0146030| 0.0104691|
|Inverse variance weighted |    4| 0.0378773| 0.0127369| 0.0029412|
|Simple mode               |    4| 0.0370173| 0.0183513| 0.1370335|
|Weighted mode             |    4| 0.0369077| 0.0190443| 0.1480024|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.1190873|    2| 0.9421944|
|Inverse variance weighted | 0.1205763|    3| 0.9892587|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0046247| 0.1198482| 0.9727245|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        3.49e-05|              0|TRUE                     |    0.5762936|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/LGALS2Conventional_Dendritic_Cell_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/LGALS2Conventional_Dendritic_Cell_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/LGALS2Conventional_Dendritic_Cell_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/LGALS2Conventional_Dendritic_Cell_against_UKBb18436chunk8-1.png)
