

# Two sample MR report

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## HLA-DQA1_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   35| 0.0018233| 0.0738146| 0.9804418|
|Weighted median           |   35| 0.0972449| 0.0110790| 0.0000000|
|Inverse variance weighted |   35| 0.0925128| 0.0117138| 0.0000000|
|Simple mode               |   35| 0.1346392| 0.0234389| 0.0000019|
|Weighted mode             |   35| 0.1138841| 0.0277366| 0.0002388|

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### Heterogeneity tests


|method                    |        Q| Q_df| Q_pval|
|:-------------------------|--------:|----:|------:|
|MR Egger                  | 128.5649|   33|      0|
|Inverse variance weighted | 134.5951|   34|      0|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|     pval|
|---------------:|---------:|--------:|
|       0.0354349| 0.0284818| 0.222218|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0004138|          7e-07|TRUE                     |    0.0631508|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/HLADQA1Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/HLADQA1Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/HLADQA1Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/HLADQA1Macrophages_against_UKBb18436chunk8-1.png)
