

# Two sample MR report

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## SPATA20_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   13| 0.0255119| 0.0322944| 0.4462360|
|Weighted median           |   13| 0.0163863| 0.0064548| 0.0111293|
|Inverse variance weighted |   13| 0.0158085| 0.0052210| 0.0024629|
|Simple mode               |   13| 0.0221041| 0.0092579| 0.0342861|
|Weighted mode             |   13| 0.0175673| 0.0081611| 0.0524023|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 14.02789|   11| 0.2314539|
|Inverse variance weighted | 14.14638|   12| 0.2914589|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0078101| 0.0256231| 0.7662016|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0008532|              0|TRUE                     |    0.0054949|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/SPATA20Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/SPATA20Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/SPATA20Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/SPATA20Macrophages_against_UKBb18436chunk8-1.png)
