

# Two sample MR report

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## LGALS2_Monocyte (Mono) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   10| 0.0432124| 0.0492554| 0.4058911|
|Weighted median           |   10| 0.0261797| 0.0074857| 0.0004700|
|Inverse variance weighted |   10| 0.0235716| 0.0060754| 0.0001045|
|Simple mode               |   10| 0.0278059| 0.0113598| 0.0368929|
|Weighted mode             |   10| 0.0278059| 0.0117038| 0.0415127|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.406800|    8| 0.9941495|
|Inverse variance weighted | 1.568261|    9| 0.9966080|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0126224| 0.0314129| 0.6983355|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0005877|              0|TRUE                     |    0.0211443|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/LGALS2Monocyte_Mono_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/LGALS2Monocyte_Mono_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/LGALS2Monocyte_Mono_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/LGALS2Monocyte_Mono_against_UKBb18436chunk8-1.png)
