

# Two sample MR report

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## KANSL1-AS1_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   71| 0.0187408| 0.0092305| 0.0461798|
|Weighted median           |   71| 0.0182739| 0.0023458| 0.0000000|
|Inverse variance weighted |   71| 0.0157285| 0.0017252| 0.0000000|
|Simple mode               |   71| 0.0187803| 0.0049571| 0.0003174|
|Weighted mode             |   71| 0.0184561| 0.0047677| 0.0002407|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 29.49618|   69| 0.9999920|
|Inverse variance weighted | 29.60654|   70| 0.9999945|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0030111| 0.0090641| 0.7407414|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0041163|              0|TRUE                     |            0|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/KANSL1AS1Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/KANSL1AS1Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/KANSL1AS1Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/KANSL1AS1Macrophages_against_UKBb18436chunk8-1.png)
