

# Two sample MR report

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## C11orf24_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3|  0.6380695| 1.7925983| 0.7822998|
|Weighted median           |    3| -0.0855317| 0.0582806| 0.1422168|
|Inverse variance weighted |    3| -0.0983562| 0.0470402| 0.0365374|
|Simple mode               |    3| -0.0850814| 0.0655858| 0.3240231|
|Weighted mode             |    3| -0.0850814| 0.0674140| 0.3341651|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0112640|    1| 0.9154778|
|Inverse variance weighted | 0.1801489|    2| 0.9138631|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.3098136| 0.7538846| 0.7517721|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        2.18e-05|              0|TRUE                     |    0.6578191|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/C11orf24Macrophages_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/C11orf24Macrophages_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/C11orf24Macrophages_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/C11orf24Macrophages_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
