

# Two sample MR report

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## C19orf33_Endothelial Cell (Endo) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3| -0.3791439| 0.8380692| 0.7295325|
|Weighted median           |    3|  0.0362912| 0.0162312| 0.0253587|
|Inverse variance weighted |    3|  0.0403388| 0.0125679| 0.0013288|
|Simple mode               |    3|  0.0344111| 0.0186865| 0.2068931|
|Weighted mode             |    3|  0.0332798| 0.0186074| 0.2155905|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.722000|    1| 0.1894358|
|Inverse variance weighted | 2.153576|    2| 0.3406880|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.3080791| 0.6153893| 0.7045147|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        5.36e-05|              0|TRUE                     |    0.4917903|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/C19orf33Endothelial_Cell_Endo_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/C19orf33Endothelial_Cell_Endo_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/C19orf33Endothelial_Cell_Endo_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/C19orf33Endothelial_Cell_Endo_against_UKBb18436chunk8-1.png)
