

# Two sample MR report

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## AKR1C2_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    7| 0.0437367| 0.0469606| 0.3944226|
|Weighted median           |    7| 0.0297978| 0.0100498| 0.0030266|
|Inverse variance weighted |    7| 0.0227678| 0.0091437| 0.0127740|
|Simple mode               |    7| 0.0304548| 0.0132878| 0.0617807|
|Weighted mode             |    7| 0.0301691| 0.0111299| 0.0350769|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 7.748409|    5| 0.1706572|
|Inverse variance weighted | 8.071495|    6| 0.2329120|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0192299| 0.0421152| 0.6671072|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001666|              0|TRUE                     |    0.2215121|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/AKR1C2Epithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/AKR1C2Epithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/AKR1C2Epithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/AKR1C2Epithelial_against_UKBb18436chunk8-1.png)
