

# Two sample MR report

---

## XRRA1_Macrophages against UKB-b-18436

Date: **13 January, 2026**

---

### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    8|  0.0739141| 0.0404207| 0.1172118|
|Weighted median           |    8| -0.0269725| 0.0095955| 0.0049396|
|Inverse variance weighted |    8| -0.0198722| 0.0087618| 0.0233260|
|Simple mode               |    8| -0.0304523| 0.0134377| 0.0578023|
|Weighted mode             |    8| -0.0314882| 0.0146288| 0.0683635|

---

### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  |  6.33571|    6| 0.3866528|
|Inverse variance weighted | 12.18727|    7| 0.0945661|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0662495| 0.0281429| 0.0567443|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0003036|              0|TRUE                     |    0.0987446|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/XRRA1Macrophages_against_UKBb18436chunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/XRRA1Macrophages_against_UKBb18436chunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/XRRA1Macrophages_against_UKBb18436chunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/XRRA1Macrophages_against_UKBb18436chunk8-1.png)
