

# Two sample MR report

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## TMEM80_Epithelial against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    5| 0.1886391| 0.2762831| 0.5437480|
|Weighted median           |    5| 0.0570601| 0.0180980| 0.0016169|
|Inverse variance weighted |    5| 0.0519597| 0.0137199| 0.0001524|
|Simple mode               |    5| 0.0619832| 0.0248470| 0.0671537|
|Weighted mode             |    5| 0.0599394| 0.0243660| 0.0696944|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.991879|    3| 0.5740939|
|Inverse variance weighted | 2.237220|    4| 0.6922211|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0757027| 0.1528362| 0.6543842|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        7.46e-05|              0|TRUE                     |    0.4154397|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/TMEM80Epithelial_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/TMEM80Epithelial_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/TMEM80Epithelial_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/TMEM80Epithelial_against_bbja88chunk8-1.png)
