

# Two sample MR report

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## TTC39C_Monocyte (Mono) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    5| 0.0389953| 0.0882873| 0.6886141|
|Weighted median           |    5| 0.0274195| 0.0100796| 0.0065221|
|Inverse variance weighted |    5| 0.0277376| 0.0085241| 0.0011379|
|Simple mode               |    5| 0.0273035| 0.0140990| 0.1248703|
|Weighted mode             |    5| 0.0279854| 0.0131695| 0.1007707|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.9825081|    3| 0.8054844|
|Inverse variance weighted | 0.9989206|    4| 0.9099596|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0083727| 0.0653551| 0.9061664|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        5.54e-05|              0|TRUE                     |     0.481724|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/TTC39CMonocyte_Mono_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/TTC39CMonocyte_Mono_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/TTC39CMonocyte_Mono_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/TTC39CMonocyte_Mono_against_UKBb18436chunk8-1.png)
