

# Two sample MR report

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## HLA-A_Alveolar Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   17| -0.0500080| 0.0565779| 0.3907088|
|Weighted median           |   17|  0.0608613| 0.0088089| 0.0000000|
|Inverse variance weighted |   17|  0.0541725| 0.0063093| 0.0000000|
|Simple mode               |   17|  0.0662488| 0.0144671| 0.0003087|
|Weighted mode             |   17|  0.0655285| 0.0147935| 0.0004207|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  |  8.686143|   15| 0.8933480|
|Inverse variance weighted | 12.119456|   16| 0.7357165|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0508781| 0.0274583| 0.0836705|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0002104|          1e-07|TRUE                     |    0.1744316|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/HLAAAlveolar_Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/HLAAAlveolar_Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/HLAAAlveolar_Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/HLAAAlveolar_Macrophages_against_UKBb18436chunk8-1.png)
