

# Two sample MR report

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## CYP4B1_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   10| 0.0830016| 0.0386893| 0.0642400|
|Weighted median           |   10| 0.0280177| 0.0126451| 0.0267124|
|Inverse variance weighted |   10| 0.0219160| 0.0098895| 0.0266858|
|Simple mode               |   10| 0.0297051| 0.0180119| 0.1335092|
|Weighted mode             |   10| 0.0302554| 0.0178927| 0.1251080|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.989354|    8| 0.9813365|
|Inverse variance weighted | 4.656470|    9| 0.8631681|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0303478| 0.0185826| 0.1410841|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001313|              0|TRUE                     |    0.2761888|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/CYP4B1Epithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/CYP4B1Epithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/CYP4B1Epithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/CYP4B1Epithelial_against_UKBb18436chunk8-1.png)
