

# Two sample MR report

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## CDH26_Epithelial against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    4| 0.0578958| 0.0751717| 0.5217264|
|Weighted median           |    4| 0.0258907| 0.0155455| 0.0958164|
|Inverse variance weighted |    4| 0.0269741| 0.0133290| 0.0429993|
|Simple mode               |    4| 0.0266769| 0.0208108| 0.2899727|
|Weighted mode             |    4| 0.0264936| 0.0181975| 0.2414423|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.4916844|    2| 0.7820456|
|Inverse variance weighted | 0.6663839|    3| 0.8810808|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0310704| 0.0743364| 0.7165697|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        4.73e-05|              0|TRUE                     |    0.5139476|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/CDH26Epithelial_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/CDH26Epithelial_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/CDH26Epithelial_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/CDH26Epithelial_against_bbja88chunk8-1.png)
