

# Two sample MR report

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## NUTM2B-AS1_Epithelial against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3|  0.1120350| 1.0693525| 0.9335444|
|Weighted median           |    3| -0.0992157| 0.0484658| 0.0406456|
|Inverse variance weighted |    3| -0.0998863| 0.0410234| 0.0148975|
|Simple mode               |    3| -0.1098119| 0.0531392| 0.1747480|
|Weighted mode             |    3| -0.0921657| 0.0557239| 0.2399549|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0686262|    1| 0.7933477|
|Inverse variance weighted | 0.1079582|    2| 0.9474519|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.1375769| 0.6937004| 0.8753609|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        4.03e-05|              0|TRUE                     |    0.5478884|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/NUTM2BAS1Epithelial_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/NUTM2BAS1Epithelial_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/NUTM2BAS1Epithelial_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/NUTM2BAS1Epithelial_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
