

# Two sample MR report

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## FAM3B_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3| -0.0705124| 0.0711870| 0.5030311|
|Weighted median           |    3| -0.0288835| 0.0131068| 0.0275449|
|Inverse variance weighted |    3| -0.0296799| 0.0100999| 0.0032967|
|Simple mode               |    3| -0.0309592| 0.0160219| 0.1930349|
|Weighted mode             |    3| -0.0264318| 0.0161083| 0.2425130|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.7637227|    1| 0.3821660|
|Inverse variance weighted | 1.0994914|    2| 0.5770965|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0397446| 0.0685896| 0.6656624|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        5.63e-05|              0|TRUE                     |    0.4783544|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/FAM3BMacrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/FAM3BMacrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/FAM3BMacrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/FAM3BMacrophages_against_UKBb18436chunk8-1.png)
