

# Two sample MR report

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## TMEM176B_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   12| -0.0736244| 0.1466435| 0.6264920|
|Weighted median           |   12| -0.0362477| 0.0188165| 0.0540565|
|Inverse variance weighted |   12| -0.0473945| 0.0151610| 0.0017716|
|Simple mode               |   12| -0.0248030| 0.0328979| 0.4667183|
|Weighted mode             |   12| -0.0242996| 0.0310312| 0.4501167|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 5.325369|   10| 0.8684107|
|Inverse variance weighted | 5.357709|   11| 0.9126137|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0163634| 0.0909923| 0.8608758|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0004391|              0|TRUE                     |    0.0464164|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/TMEM176BMacrophages_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/TMEM176BMacrophages_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/TMEM176BMacrophages_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/TMEM176BMacrophages_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
