

# Two sample MR report

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## KDELR2_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    8| 0.0372717| 0.0679152| 0.6029519|
|Weighted median           |    8| 0.0305468| 0.0157192| 0.0519822|
|Inverse variance weighted |    8| 0.0265509| 0.0135439| 0.0499535|
|Simple mode               |    8| 0.0310754| 0.0240406| 0.2371696|
|Weighted mode             |    8| 0.0311883| 0.0233995| 0.2243227|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.8178579|    6| 0.9915863|
|Inverse variance weighted | 0.8438080|    7| 0.9969708|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0052416| 0.0325385| 0.8773093|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        8.74e-05|              0|TRUE                     |    0.3739228|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/KDELR2Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/KDELR2Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/KDELR2Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/KDELR2Macrophages_against_UKBb18436chunk8-1.png)
