

# Two sample MR report

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## METTL9_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    5| 0.0063206| 0.0481668| 0.9039041|
|Weighted median           |    5| 0.0164376| 0.0103352| 0.1117334|
|Inverse variance weighted |    5| 0.0201974| 0.0087089| 0.0203858|
|Simple mode               |    5| 0.0162358| 0.0129887| 0.2794443|
|Weighted mode             |    5| 0.0160655| 0.0112610| 0.2268406|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.7986009|    3| 0.8498017|
|Inverse variance weighted | 0.8844070|    4| 0.9267871|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|     pval|
|---------------:|--------:|--------:|
|       0.0098798| 0.033728| 0.788671|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0002229|              0|TRUE                     |    0.1556936|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/METTL9Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/METTL9Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/METTL9Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/METTL9Macrophages_against_UKBb18436chunk8-1.png)
