

# Two sample MR report

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## TMEM220_Epithelial against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    4| 0.2293665| 0.7324092| 0.7837949|
|Weighted median           |    4| 0.0637358| 0.0192995| 0.0009584|
|Inverse variance weighted |    4| 0.0595355| 0.0163055| 0.0002610|
|Simple mode               |    4| 0.0644931| 0.0266415| 0.0941033|
|Weighted mode             |    4| 0.0644931| 0.0255432| 0.0858100|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.5470510|    2| 0.7606930|
|Inverse variance weighted | 0.6008459|    3| 0.8962387|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0893582| 0.3852688| 0.8381576|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001143|              0|TRUE                     |    0.3134594|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/TMEM220Epithelial_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/TMEM220Epithelial_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/TMEM220Epithelial_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/TMEM220Epithelial_against_bbja88chunk8-1.png)
