

# Two sample MR report

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## DOCK9_Monocyte (Mono) against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3| -0.1140381| 0.1181661| 0.5113163|
|Weighted median           |    3| -0.0814373| 0.0288794| 0.0048037|
|Inverse variance weighted |    3| -0.0830030| 0.0232060| 0.0003478|
|Simple mode               |    3| -0.0805554| 0.0329641| 0.1344850|
|Weighted mode             |    3| -0.0797033| 0.0338942| 0.1430371|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.1218817|    1| 0.7270025|
|Inverse variance weighted | 0.1936281|    2| 0.9077248|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0316316| 0.1180921| 0.8333892|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        3.02e-05|              0|TRUE                     |    0.6075336|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/DOCK9Monocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/DOCK9Monocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/DOCK9Monocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/DOCK9Monocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
