

# Two sample MR report

---

## HLA-DQA2_Dendritic Cell (DC) against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

---

### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   54| -0.1187454| 0.0523102| 0.0273789|
|Weighted median           |   54|  0.0306493| 0.0088554| 0.0005380|
|Inverse variance weighted |   54|  0.0416821| 0.0064649| 0.0000000|
|Simple mode               |   54|  0.0153437| 0.0221728| 0.4919547|
|Weighted mode             |   54|  0.0159027| 0.0195255| 0.4190268|

---

### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 25.33836|   52| 0.9993264|
|Inverse variance weighted | 34.88983|   53| 0.9741319|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.1164478| 0.0376787| 0.0032066|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0009312|              0|TRUE                     |     0.003841|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/HLADQA2Dendritic_Cell_DC_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/HLADQA2Dendritic_Cell_DC_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/HLADQA2Dendritic_Cell_DC_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/HLADQA2Dendritic_Cell_DC_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
