

# Two sample MR report

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## SPATC1L_Monocyte (Mono) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   10|  0.0604741| 0.0396951| 0.1661454|
|Weighted median           |   10| -0.0064693| 0.0070085| 0.3559730|
|Inverse variance weighted |   10| -0.0122421| 0.0054440| 0.0245290|
|Simple mode               |   10| -0.0058276| 0.0109690| 0.6080864|
|Weighted mode             |   10| -0.0058276| 0.0106313| 0.5969177|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.800194|    8| 0.9865365|
|Inverse variance weighted | 5.220259|    9| 0.8147005|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0775686| 0.0419439| 0.1015792|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|         8.2e-05|              0|TRUE                     |     0.391411|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/SPATC1LMonocyte_Mono_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/SPATC1LMonocyte_Mono_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/SPATC1LMonocyte_Mono_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/SPATC1LMonocyte_Mono_against_UKBb18436chunk8-1.png)
