

# Two sample MR report

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## ELP5_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   13| -0.0073388| 0.0310075| 0.8172560|
|Weighted median           |   13| -0.0190468| 0.0053426| 0.0003637|
|Inverse variance weighted |   13| -0.0188567| 0.0042093| 0.0000075|
|Simple mode               |   13| -0.0186733| 0.0080059| 0.0379026|
|Weighted mode             |   13| -0.0185463| 0.0069216| 0.0200560|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 5.322811|   11| 0.9145310|
|Inverse variance weighted | 5.463378|   12| 0.9406874|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0094746| 0.0252706| 0.7148454|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0010881|              0|TRUE                     |     0.001718|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/ELP5Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/ELP5Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/ELP5Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/ELP5Macrophages_against_UKBb18436chunk8-1.png)
