

# Two sample MR report

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## THBS1_Monocyte (Mono) against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    4| -0.1172761| 1.1237801| 0.9264074|
|Weighted median           |    4| -0.1705354| 0.0827795| 0.0393875|
|Inverse variance weighted |    4| -0.1742504| 0.0749638| 0.0201009|
|Simple mode               |    4| -0.1680850| 0.1158796| 0.2428038|
|Weighted mode             |    4| -0.1675804| 0.1126659| 0.2336276|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0736964|    2| 0.9638224|
|Inverse variance weighted | 0.0762783|    3| 0.9945235|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0136639| 0.2689109| 0.9640937|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|         6.8e-05|              0|TRUE                     |    0.4337384|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/THBS1Monocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/THBS1Monocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/THBS1Monocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/THBS1Monocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
