

# Two sample MR report

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## RPS26_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   20| -0.0211312| 0.0251350| 0.4115411|
|Weighted median           |   20| -0.0398427| 0.0069036| 0.0000000|
|Inverse variance weighted |   20| -0.0514305| 0.0049006| 0.0000000|
|Simple mode               |   20| -0.0717961| 0.0120156| 0.0000095|
|Weighted mode             |   20| -0.0378098| 0.0089252| 0.0004468|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 18.11622|   18| 0.4480214|
|Inverse variance weighted | 19.63496|   19| 0.4168368|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       -0.019537| 0.0159042| 0.2351115|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0028678|          2e-07|TRUE                     |        4e-07|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/RPS26Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/RPS26Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/RPS26Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/RPS26Macrophages_against_UKBb18436chunk8-1.png)
