

# Two sample MR report

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## PLA2G16_Monocyte (Mono) against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3| -0.0238078| 0.1572362| 0.9043333|
|Weighted median           |    3| -0.0331097| 0.0139041| 0.0172520|
|Inverse variance weighted |    3| -0.0346158| 0.0116593| 0.0029882|
|Simple mode               |    3| -0.0325541| 0.0150807| 0.1635246|
|Weighted mode             |    3| -0.0323501| 0.0142676| 0.1515136|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0740927|    1| 0.7854684|
|Inverse variance weighted | 0.0788436|    2| 0.9613451|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0094433| 0.1370043| 0.9561891|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001186|              0|TRUE                     |    0.3020402|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/PLA2G16Monocyte_Mono_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/PLA2G16Monocyte_Mono_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/PLA2G16Monocyte_Mono_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/PLA2G16Monocyte_Mono_against_bbja88chunk8-1.png)
