

# Two sample MR report

---

## THBS1_Alveolar Macrophages against UKB-b-18436

Date: **13 January, 2026**

---

### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   22|  0.0605393| 0.0728154| 0.4155593|
|Weighted median           |   22| -0.0276563| 0.0064579| 0.0000185|
|Inverse variance weighted |   22| -0.0177646| 0.0048516| 0.0002506|
|Simple mode               |   22| -0.0339061| 0.0131892| 0.0178197|
|Weighted mode             |   22| -0.0333562| 0.0130401| 0.0183231|

---

### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 21.63072|   20| 0.3608800|
|Inverse variance weighted | 22.88698|   21| 0.3500338|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0434694| 0.0403334| 0.2939723|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0004333|              0|TRUE                     |    0.0485453|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/THBS1Alveolar_Macrophages_against_UKBb18436chunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/THBS1Alveolar_Macrophages_against_UKBb18436chunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/THBS1Alveolar_Macrophages_against_UKBb18436chunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/THBS1Alveolar_Macrophages_against_UKBb18436chunk8-1.png)
