

# Two sample MR report

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## LTC4S_Endothelial Cell (Endo) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3|  0.2869946| 0.6832360| 0.7468341|
|Weighted median           |    3| -0.0408751| 0.0165574| 0.0135610|
|Inverse variance weighted |    3| -0.0411218| 0.0136387| 0.0025691|
|Simple mode               |    3| -0.0422628| 0.0187893| 0.1534255|
|Weighted mode             |    3| -0.0401547| 0.0194562| 0.1750855|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0060737|    1| 0.9378807|
|Inverse variance weighted | 0.2367948|    2| 0.8883430|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|     pval|
|---------------:|---------:|--------:|
|      -0.1756638| 0.3657115| 0.714927|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|           4e-05|              0|TRUE                     |    0.5501537|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/LTC4SEndothelial_Cell_Endo_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/LTC4SEndothelial_Cell_Endo_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/LTC4SEndothelial_Cell_Endo_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/LTC4SEndothelial_Cell_Endo_against_UKBb18436chunk8-1.png)
