

# Two sample MR report

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## ZNF506_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    6| -0.0741243| 0.1384797| 0.6208354|
|Weighted median           |    6|  0.0141122| 0.0103948| 0.1745837|
|Inverse variance weighted |    6|  0.0176656| 0.0083721| 0.0348525|
|Simple mode               |    6|  0.0136357| 0.0146147| 0.3936413|
|Weighted mode             |    6|  0.0131733| 0.0130320| 0.3584792|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.4258505|    4| 0.9803063|
|Inverse variance weighted | 0.8668197|    5| 0.9725771|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0721591| 0.1086643| 0.5429763|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        5.75e-05|              0|TRUE                     |     0.471187|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/ZNF506Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/ZNF506Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/ZNF506Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/ZNF506Macrophages_against_UKBb18436chunk8-1.png)
