

# Two sample MR report

---

## TOR1B_Macrophages against UKB-b-18436

Date: **13 January, 2026**

---

### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    6| 0.0663074| 0.1687576| 0.7144226|
|Weighted median           |    6| 0.0332628| 0.0146136| 0.0228364|
|Inverse variance weighted |    6| 0.0333249| 0.0124060| 0.0072274|
|Simple mode               |    6| 0.0332464| 0.0210350| 0.1748265|
|Weighted mode             |    6| 0.0333813| 0.0187433| 0.1350266|

---

### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0377064|    4| 0.9998245|
|Inverse variance weighted | 0.0761120|    5| 0.9999173|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0147648| 0.0753409| 0.8541841|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        9.44e-05|              0|TRUE                     |    0.3564807|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/TOR1BMacrophages_against_UKBb18436chunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/TOR1BMacrophages_against_UKBb18436chunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/TOR1BMacrophages_against_UKBb18436chunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/TOR1BMacrophages_against_UKBb18436chunk8-1.png)
