

# Two sample MR report

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## DRC1_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   10| -0.0697538| 0.0615682| 0.2900452|
|Weighted median           |   10| -0.0217604| 0.0119552| 0.0687356|
|Inverse variance weighted |   10| -0.0228629| 0.0096499| 0.0178253|
|Simple mode               |   10| -0.0326849| 0.0186537| 0.1136500|
|Weighted mode             |   10| -0.0178969| 0.0186737| 0.3628974|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.917168|    8| 0.9834468|
|Inverse variance weighted | 2.511824|    9| 0.9805638|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|        0.029656| 0.0384574| 0.4627897|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001356|              0|TRUE                     |    0.2686315|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/DRC1Epithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/DRC1Epithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/DRC1Epithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/DRC1Epithelial_against_UKBb18436chunk8-1.png)
