

# Two sample MR report

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## HLA-DRB5_Endothelial Cell (Endo) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   20| -0.0124600| 0.0251558| 0.6263727|
|Weighted median           |   20| -0.0192788| 0.0064609| 0.0028459|
|Inverse variance weighted |   20| -0.0196132| 0.0049360| 0.0000708|
|Simple mode               |   20| -0.0186620| 0.0099918| 0.0773040|
|Weighted mode             |   20| -0.0176025| 0.0091513| 0.0695329|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 5.821345|   18| 0.9968686|
|Inverse variance weighted | 5.905441|   19| 0.9981432|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0055994| 0.0193086| 0.7751357|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0003904|              0|TRUE                     |    0.0608853|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/HLADRB5Endothelial_Cell_Endo_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/HLADRB5Endothelial_Cell_Endo_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/HLADRB5Endothelial_Cell_Endo_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/HLADRB5Endothelial_Cell_Endo_against_UKBb18436chunk8-1.png)
