

# Two sample MR report

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## C19orf60_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    5| 0.0365672| 0.1053910| 0.7515286|
|Weighted median           |    5| 0.0292228| 0.0142319| 0.0400400|
|Inverse variance weighted |    5| 0.0286933| 0.0121661| 0.0183506|
|Simple mode               |    5| 0.0300632| 0.0194775| 0.1975886|
|Weighted mode             |    5| 0.0302011| 0.0177632| 0.1643149|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0712921|    3| 0.9950442|
|Inverse variance weighted | 0.0769492|    4| 0.9992786|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0036157| 0.0480721| 0.9447793|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001146|              0|TRUE                     |    0.3087455|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/C19orf60Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/C19orf60Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/C19orf60Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/C19orf60Macrophages_against_UKBb18436chunk8-1.png)
