

# Two sample MR report

---

## SPATA20_Alveolar Macrophages against UKB-b-18436

Date: **13 January, 2026**

---

### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    4| -0.0597525| 0.2196021| 0.8110654|
|Weighted median           |    4|  0.0194668| 0.0095133| 0.0407301|
|Inverse variance weighted |    4|  0.0196435| 0.0084111| 0.0195208|
|Simple mode               |    4|  0.0191767| 0.0127406| 0.2293483|
|Weighted mode             |    4|  0.0190939| 0.0126267| 0.2276787|

---

### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0155932|    2| 0.9922337|
|Inverse variance weighted | 0.1465000|    3| 0.9857253|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|       0.0578227| 0.159815| 0.7521443|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        7.03e-05|              0|TRUE                     |    0.4257706|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/SPATA20Alveolar_Macrophages_against_UKBb18436chunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/SPATA20Alveolar_Macrophages_against_UKBb18436chunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/SPATA20Alveolar_Macrophages_against_UKBb18436chunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/SPATA20Alveolar_Macrophages_against_UKBb18436chunk8-1.png)
