

# Two sample MR report

---

## HLA-A_Monocyte (Mono) against UKB-b-18436

Date: **13 January, 2026**

---

### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   17| 0.0752553| 0.0552075| 0.1929521|
|Weighted median           |   17| 0.0662303| 0.0089076| 0.0000000|
|Inverse variance weighted |   17| 0.0638016| 0.0067614| 0.0000000|
|Simple mode               |   17| 0.0680922| 0.0148484| 0.0003045|
|Weighted mode             |   17| 0.0676185| 0.0146915| 0.0002942|

---

### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 2.069491|   15| 0.9999628|
|Inverse variance weighted | 2.113189|   16| 0.9999849|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0051475| 0.0246246| 0.8372287|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0003886|          1e-07|TRUE                     |    0.0640801|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/HLAAMonocyte_Mono_against_UKBb18436chunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/HLAAMonocyte_Mono_against_UKBb18436chunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/HLAAMonocyte_Mono_against_UKBb18436chunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/HLAAMonocyte_Mono_against_UKBb18436chunk8-1.png)
