

# Two sample MR report

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## TMEM176B_Monocyte (Mono) against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    9|  0.0551266| 0.2179661| 0.8076015|
|Weighted median           |    9| -0.0259184| 0.0222177| 0.2433872|
|Inverse variance weighted |    9| -0.0438448| 0.0175330| 0.0123946|
|Simple mode               |    9| -0.0176233| 0.0371239| 0.6476780|
|Weighted mode             |    9| -0.0181247| 0.0356016| 0.6244247|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 4.097032|    7| 0.7685358|
|Inverse variance weighted | 4.304553|    8| 0.8286536|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0609778| 0.1338572| 0.6625123|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0003172|              0|TRUE                     |    0.0904986|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/TMEM176BMonocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/TMEM176BMonocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/TMEM176BMonocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/TMEM176BMonocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
