

# Two sample MR report

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## SNHG8_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   11|  0.0327281| 0.0487900| 0.5191933|
|Weighted median           |   11| -0.0297198| 0.0106924| 0.0054437|
|Inverse variance weighted |   11| -0.0294305| 0.0082091| 0.0003369|
|Simple mode               |   11| -0.0284773| 0.0175197| 0.1351292|
|Weighted mode             |   11| -0.0290574| 0.0154552| 0.0895091|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 3.903040|    9| 0.9176774|
|Inverse variance weighted | 5.573409|   10| 0.8497408|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0290259| 0.0224585| 0.2284036|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0002271|              0|TRUE                     |    0.1534308|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/SNHG8Epithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/SNHG8Epithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/SNHG8Epithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/SNHG8Epithelial_against_UKBb18436chunk8-1.png)
