

# Two sample MR report

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## HLA-C_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   40| -0.0256480| 0.0602995| 0.6729861|
|Weighted median           |   40| -0.0349978| 0.0148595| 0.0185105|
|Inverse variance weighted |   40| -0.0541697| 0.0106469| 0.0000004|
|Simple mode               |   40| -0.0255360| 0.0319585| 0.4291088|
|Weighted mode             |   40| -0.0293860| 0.0312995| 0.3535780|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 32.72065|   38| 0.7118027|
|Inverse variance weighted | 32.95158|   39| 0.7412653|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0161499| 0.0336069| 0.6335902|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        0.000692|              0|TRUE                     |    0.0127837|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/HLACMacrophages_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/HLACMacrophages_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/HLACMacrophages_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/HLACMacrophages_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
