

# Two sample MR report

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## CD52_Dendritic Cell (DC) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    5| 0.2512229| 0.3072220| 0.4734175|
|Weighted median           |    5| 0.0810849| 0.0215240| 0.0001651|
|Inverse variance weighted |    5| 0.0596763| 0.0285446| 0.0365612|
|Simple mode               |    5| 0.0842465| 0.0228576| 0.0210981|
|Weighted mode             |    5| 0.0842465| 0.0214681| 0.0171859|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 12.13552|    3| 0.0069331|
|Inverse variance weighted | 13.72415|    4| 0.0082295|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0816299| 0.1302584| 0.5753177|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        8.16e-05|              0|TRUE                     |    0.3963143|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/CD52Dendritic_Cell_DC_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/CD52Dendritic_Cell_DC_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/CD52Dendritic_Cell_DC_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/CD52Dendritic_Cell_DC_against_UKBb18436chunk8-1.png)
