

# Two sample MR report

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## UCHL3_Epithelial against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    5| -0.0664000| 0.1737688| 0.7278365|
|Weighted median           |    5| -0.0267638| 0.0142689| 0.0607002|
|Inverse variance weighted |    5| -0.0314975| 0.0116856| 0.0070302|
|Simple mode               |    5| -0.0254830| 0.0183350| 0.2369256|
|Weighted mode             |    5| -0.0254076| 0.0174622| 0.2193621|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.5541019|    3| 0.9068545|
|Inverse variance weighted | 0.5946285|    4| 0.9636587|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0268553| 0.1334014| 0.8533312|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        5.91e-05|              0|TRUE                     |    0.4670071|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/UCHL3Epithelial_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/UCHL3Epithelial_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/UCHL3Epithelial_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/UCHL3Epithelial_against_bbja88chunk8-1.png)
