

# Two sample MR report

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## CFB_Dendritic Cell (DC) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   21| -0.0276062| 0.0207167| 0.1984392|
|Weighted median           |   21|  0.0052018| 0.0035644| 0.1444677|
|Inverse variance weighted |   21|  0.0055356| 0.0026596| 0.0374009|
|Simple mode               |   21|  0.0045358| 0.0067348| 0.5083502|
|Weighted mode             |   21|  0.0038724| 0.0065450| 0.5607105|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  |  7.893374|   19| 0.9877120|
|Inverse variance weighted | 10.495499|   20| 0.9582723|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0413357| 0.0256248| 0.1232067|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0003345|              0|TRUE                     |    0.0822893|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/CFBDendritic_Cell_DC_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/CFBDendritic_Cell_DC_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/CFBDendritic_Cell_DC_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/CFBDendritic_Cell_DC_against_UKBb18436chunk8-1.png)
