

# Two sample MR report

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## RAC1_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    4| 0.1253881| 0.8775626| 0.8994787|
|Weighted median           |    4| 0.1577136| 0.0567077| 0.0054164|
|Inverse variance weighted |    4| 0.1604327| 0.0480746| 0.0008464|
|Simple mode               |    4| 0.1534281| 0.0735389| 0.1282223|
|Weighted mode             |    4| 0.1523080| 0.0728018| 0.1275226|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.1862663|    2| 0.9110722|
|Inverse variance weighted | 0.1878659|    3| 0.9795240|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0116526| 0.2913588| 0.9717312|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|         4.2e-05|              0|TRUE                     |    0.5411717|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/RAC1Macrophages_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/RAC1Macrophages_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/RAC1Macrophages_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/RAC1Macrophages_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
