

# Two sample MR report

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## GSN_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    4| -0.1988549| 1.2865749| 0.8913555|
|Weighted median           |    4|  0.0408224| 0.0155740| 0.0087623|
|Inverse variance weighted |    4|  0.0382117| 0.0130304| 0.0033625|
|Simple mode               |    4|  0.0417479| 0.0226364| 0.1623445|
|Weighted mode             |    4|  0.0416384| 0.0200279| 0.1291237|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.6185680|    2| 0.7339723|
|Inverse variance weighted | 0.6525239|    3| 0.8843098|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.1096627| 0.5951158| 0.8707928|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        4.47e-05|              0|TRUE                     |    0.5273287|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/GSNMacrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/GSNMacrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/GSNMacrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/GSNMacrophages_against_UKBb18436chunk8-1.png)
