

# Two sample MR report

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## PNPLA6_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    4| -0.0182235| 0.0220851| 0.4960414|
|Weighted median           |    4| -0.0203193| 0.0112611| 0.0711710|
|Inverse variance weighted |    4| -0.0201174| 0.0095457| 0.0350752|
|Simple mode               |    4| -0.0202616| 0.0138045| 0.2384685|
|Weighted mode             |    4| -0.0201774| 0.0142717| 0.2523228|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0051342|    2| 0.9974362|
|Inverse variance weighted | 0.0141770|    3| 0.9995530|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|    pval|
|---------------:|---------:|-------:|
|      -0.0019357| 0.0203555| 0.93291|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        2.75e-05|              0|TRUE                     |    0.6188827|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/PNPLA6Epithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/PNPLA6Epithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/PNPLA6Epithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/PNPLA6Epithelial_against_UKBb18436chunk8-1.png)
