

# Two sample MR report

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## SLC26A2_T Proliferating against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3|  0.0672558| 0.2750887| 0.8473489|
|Weighted median           |    3| -0.0427996| 0.0165263| 0.0096035|
|Inverse variance weighted |    3| -0.0398683| 0.0135715| 0.0033071|
|Simple mode               |    3| -0.0436824| 0.0190004| 0.1482473|
|Weighted mode             |    3| -0.0435934| 0.0199715| 0.1607498|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0221477|    1| 0.8816947|
|Inverse variance weighted | 0.1741630|    2| 0.9166024|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0899162| 0.2306187| 0.7633291|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        2.88e-05|              0|TRUE                     |    0.6128238|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/SLC26A2T_Proliferating_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/SLC26A2T_Proliferating_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/SLC26A2T_Proliferating_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/SLC26A2T_Proliferating_against_bbja88chunk8-1.png)
