

# Two sample MR report

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## ENOSF1_Epithelial against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   14| -0.0549033| 0.1446032| 0.7108153|
|Weighted median           |   14|  0.0551807| 0.0135939| 0.0000492|
|Inverse variance weighted |   14|  0.0588654| 0.0104985| 0.0000000|
|Simple mode               |   14|  0.0618645| 0.0216805| 0.0135667|
|Weighted mode             |   14|  0.0527867| 0.0210551| 0.0262362|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 2.978578|   12| 0.9956934|
|Inverse variance weighted | 3.600857|   13| 0.9947438|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0493749| 0.0625913| 0.4455075|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0002177|              0|TRUE                     |    0.1640621|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/ENOSF1Epithelial_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/ENOSF1Epithelial_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/ENOSF1Epithelial_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/ENOSF1Epithelial_against_bbja88chunk8-1.png)
