

# Two sample MR report

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## RDX_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    7| 0.1209292| 0.1266326| 0.3834534|
|Weighted median           |    7| 0.0333468| 0.0195034| 0.0873035|
|Inverse variance weighted |    7| 0.0287835| 0.0144591| 0.0465167|
|Simple mode               |    7| 0.0412908| 0.0289911| 0.2042392|
|Weighted mode             |    7| 0.0369547| 0.0299553| 0.2634610|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 4.150282|    5| 0.5279884|
|Inverse variance weighted | 4.686768|    6| 0.5845679|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|      -0.0610763| 0.083386| 0.4967684|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001106|              0|TRUE                     |    0.3179555|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/RDXMacrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/RDXMacrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/RDXMacrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/RDXMacrophages_against_UKBb18436chunk8-1.png)
