

# Two sample MR report

---

## GBP3_Macrophages against UKB-b-18436

Date: **13 January, 2026**

---

### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   21|  0.0170669| 0.0338282| 0.6196983|
|Weighted median           |   21| -0.0138074| 0.0062236| 0.0265171|
|Inverse variance weighted |   21| -0.0149434| 0.0047485| 0.0016497|
|Simple mode               |   21| -0.0151013| 0.0115234| 0.2048802|
|Weighted mode             |   21| -0.0145061| 0.0101346| 0.1677731|

---

### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 10.57311|   19| 0.9373650|
|Inverse variance weighted | 11.48652|   20| 0.9326173|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|       -0.018738| 0.019606| 0.3512136|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0009052|              0|TRUE                     |    0.0041936|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/GBP3Macrophages_against_UKBb18436chunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/GBP3Macrophages_against_UKBb18436chunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/GBP3Macrophages_against_UKBb18436chunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/GBP3Macrophages_against_UKBb18436chunk8-1.png)
