

# Two sample MR report

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## SPATA20_Interstitial Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    4| -0.0369808| 0.2350043| 0.8894106|
|Weighted median           |    4|  0.0206937| 0.0099030| 0.0366505|
|Inverse variance weighted |    4|  0.0204170| 0.0087248| 0.0192777|
|Simple mode               |    4|  0.0213887| 0.0134883| 0.2109847|
|Weighted mode             |    4|  0.0213046| 0.0139279| 0.2235903|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0648657|    2| 0.9680875|
|Inverse variance weighted | 0.1246019|    3| 0.9887299|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|       0.0402971| 0.164875| 0.8297006|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        4.52e-05|              0|TRUE                     |     0.523151|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/SPATA20Interstitial_Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/SPATA20Interstitial_Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/SPATA20Interstitial_Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/SPATA20Interstitial_Macrophages_against_UKBb18436chunk8-1.png)
