

# Two sample MR report

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## ADK_Monocyte (Mono) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    5| -0.0179013| 0.0467515| 0.7273107|
|Weighted median           |    5| -0.0190423| 0.0090383| 0.0351302|
|Inverse variance weighted |    5| -0.0205805| 0.0074479| 0.0057225|
|Simple mode               |    5| -0.0161456| 0.0110610| 0.2181501|
|Weighted mode             |    5| -0.0165926| 0.0117962| 0.2322797|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.4603173|    3| 0.9275189|
|Inverse variance weighted | 0.4636869|    4| 0.9769384|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0026601| 0.0458248| 0.9573603|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        8.85e-05|              0|TRUE                     |    0.3719622|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/ADKMonocyte_Mono_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/ADKMonocyte_Mono_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/ADKMonocyte_Mono_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/ADKMonocyte_Mono_against_UKBb18436chunk8-1.png)
