

# Two sample MR report

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## STX11_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3|  0.2110156| 0.1569455| 0.4071165|
|Weighted median           |    3| -0.0304186| 0.0144884| 0.0357719|
|Inverse variance weighted |    3| -0.0419328| 0.0130621| 0.0013261|
|Simple mode               |    3| -0.0298262| 0.0170099| 0.2216152|
|Weighted mode             |    3| -0.0297194| 0.0161419| 0.2069495|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.5833465|    1| 0.4450036|
|Inverse variance weighted | 3.1922326|    2| 0.2026821|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.1915674| 0.1186025| 0.3529149|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        2.19e-05|              0|TRUE                     |    0.6652827|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/STX11Epithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/STX11Epithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/STX11Epithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/STX11Epithelial_against_UKBb18436chunk8-1.png)
