

# Two sample MR report

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## TBCA_Epithelial against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    4| -0.3746324| 1.4072239| 0.8150027|
|Weighted median           |    4|  0.1689485| 0.0765372| 0.0272858|
|Inverse variance weighted |    4|  0.1671786| 0.0637253| 0.0087050|
|Simple mode               |    4|  0.1656143| 0.0967395| 0.1854251|
|Weighted mode             |    4|  0.1651118| 0.0862682| 0.1515383|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.1420337|    2| 0.9314462|
|Inverse variance weighted | 0.2905797|    3| 0.9617903|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.2574818| 0.6680611| 0.7370591|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        6.02e-05|              0|TRUE                     |    0.4623526|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/TBCAEpithelial_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/TBCAEpithelial_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/TBCAEpithelial_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/TBCAEpithelial_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
