

# Two sample MR report

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## LAP3_Monocyte (Mono) against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   11| -0.0566244| 0.6019254| 0.9271128|
|Weighted median           |   11|  0.1098545| 0.0332351| 0.0009485|
|Inverse variance weighted |   11|  0.1100710| 0.0251996| 0.0000125|
|Simple mode               |   11|  0.1213664| 0.0459258| 0.0246213|
|Weighted mode             |   11|  0.1046892| 0.0449148| 0.0419903|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.5751788|    9| 0.9999446|
|Inverse variance weighted | 0.6520075|   10| 0.9999766|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|       0.0674368| 0.243296| 0.7879031|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001747|              0|TRUE                     |    0.2113637|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/LAP3Monocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/LAP3Monocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/LAP3Monocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/LAP3Monocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
