

# Two sample MR report

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## ELP5_Monocyte (Mono) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   11| -0.0074610| 0.0553774| 0.8957902|
|Weighted median           |   11| -0.0233187| 0.0067817| 0.0005850|
|Inverse variance weighted |   11| -0.0250363| 0.0054033| 0.0000036|
|Simple mode               |   11| -0.0223921| 0.0104672| 0.0581083|
|Weighted mode             |   11| -0.0223087| 0.0099664| 0.0491376|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.4246950|    9| 0.9999849|
|Inverse variance weighted | 0.5263891|   10| 0.9999915|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0119237| 0.0373908| 0.7570828|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0002356|              0|TRUE                     |    0.1461165|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/ELP5Monocyte_Mono_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/ELP5Monocyte_Mono_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/ELP5Monocyte_Mono_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/ELP5Monocyte_Mono_against_UKBb18436chunk8-1.png)
