

# Two sample MR report

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## UBXN11_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    6|  0.1578579| 0.0713247| 0.0912973|
|Weighted median           |    6| -0.0679348| 0.0167027| 0.0000476|
|Inverse variance weighted |    6| -0.0456380| 0.0212353| 0.0316218|
|Simple mode               |    6| -0.0748691| 0.0211924| 0.0166895|
|Weighted mode             |    6| -0.0732286| 0.0216546| 0.0196384|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  |  5.239846|    4| 0.2635611|
|Inverse variance weighted | 16.297025|    5| 0.0060453|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.1144496| 0.0393932| 0.0438837|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        4.97e-05|              0|TRUE                     |    0.5097941|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/UBXN11Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/UBXN11Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/UBXN11Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/UBXN11Macrophages_against_UKBb18436chunk8-1.png)
