

# Two sample MR report

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## HLA-A_Endothelial Cell (Endo) against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    6|  0.1694039| 0.4048094| 0.6970895|
|Weighted median           |    6| -0.1188835| 0.0264387| 0.0000069|
|Inverse variance weighted |    6| -0.1034989| 0.0215560| 0.0000016|
|Simple mode               |    6| -0.1382763| 0.0398481| 0.0178477|
|Weighted mode             |    6| -0.1378213| 0.0444123| 0.0267553|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 6.240483|    4| 0.1818943|
|Inverse variance weighted | 6.951789|    5| 0.2242506|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.1121147| 0.1660403| 0.5365525|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        7.25e-05|              0|TRUE                     |    0.4279028|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/HLAAEndothelial_Cell_Endo_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/HLAAEndothelial_Cell_Endo_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/HLAAEndothelial_Cell_Endo_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/HLAAEndothelial_Cell_Endo_against_bbja88chunk8-1.png)
