

# Two sample MR report

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## ICAM4_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    4|  0.0331940| 0.1481046| 0.8434729|
|Weighted median           |    4| -0.0643132| 0.0318933| 0.0437462|
|Inverse variance weighted |    4| -0.0535048| 0.0256059| 0.0366585|
|Simple mode               |    4| -0.0844249| 0.0457469| 0.1621520|
|Weighted mode             |    4| -0.0834394| 0.0462906| 0.1692532|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 2.433806|    2| 0.2961460|
|Inverse variance weighted | 2.866556|    3| 0.4126606|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       -0.059909| 0.1004619| 0.6114578|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        5.05e-05|              0|TRUE                     |    0.5007154|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/ICAM4Macrophages_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/ICAM4Macrophages_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/ICAM4Macrophages_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/ICAM4Macrophages_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
