

# Two sample MR report

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## SRSF2_Conventional Dendritic Cell against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3| -0.3944721| 0.9072212| 0.7388882|
|Weighted median           |    3| -0.2527763| 0.0566945| 0.0000083|
|Inverse variance weighted |    3| -0.2488480| 0.0428709| 0.0000000|
|Simple mode               |    3| -0.2567834| 0.0680633| 0.0636255|
|Weighted mode             |    3| -0.2564238| 0.0630983| 0.0555531|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0649215|    1| 0.7988799|
|Inverse variance weighted | 0.0907448|    2| 0.9556416|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0619746| 0.3856633| 0.8985648|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        5.51e-05|          1e-07|TRUE                     |    0.4926967|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/SRSF2Conventional_Dendritic_Cell_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/SRSF2Conventional_Dendritic_Cell_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/SRSF2Conventional_Dendritic_Cell_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/SRSF2Conventional_Dendritic_Cell_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
