

# Two sample MR report

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## RNASET2_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    8| 0.0518771| 0.2106880| 0.8137135|
|Weighted median           |    8| 0.0584829| 0.0132527| 0.0000102|
|Inverse variance weighted |    8| 0.0581650| 0.0102344| 0.0000000|
|Simple mode               |    8| 0.0593128| 0.0188073| 0.0160686|
|Weighted mode             |    8| 0.0586460| 0.0180288| 0.0140008|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.454075|    6| 0.9624866|
|Inverse variance weighted | 1.454968|    7| 0.9838279|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|        0.002643| 0.0884535| 0.9771321|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001392|              0|TRUE                     |    0.2665409|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/RNASET2Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/RNASET2Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/RNASET2Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/RNASET2Macrophages_against_UKBb18436chunk8-1.png)
