

# Two sample MR report

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## GSTA1_Epithelial against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    7| -0.0843306| 0.1680012| 0.6370112|
|Weighted median           |    7| -0.0406249| 0.0181015| 0.0248145|
|Inverse variance weighted |    7| -0.0385104| 0.0154888| 0.0129068|
|Simple mode               |    7| -0.0416353| 0.0254379| 0.1527989|
|Weighted mode             |    7| -0.0415347| 0.0253437| 0.1523547|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.3697306|    5| 0.9961225|
|Inverse variance weighted | 0.4447542|    6| 0.9984473|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0261166| 0.0953493| 0.7951132|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0005418|              0|TRUE                     |    0.0267058|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/GSTA1Epithelial_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/GSTA1Epithelial_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/GSTA1Epithelial_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/GSTA1Epithelial_against_bbja88chunk8-1.png)
