

# Two sample MR report

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## KANSL1-AS1_Conventional Dendritic Cell against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3| -0.0512896| 0.3373068| 0.9039339|
|Weighted median           |    3|  0.0213348| 0.0124762| 0.0872590|
|Inverse variance weighted |    3|  0.0202972| 0.0096372| 0.0351931|
|Simple mode               |    3|  0.0222770| 0.0127847| 0.2235487|
|Weighted mode             |    3|  0.0222210| 0.0131403| 0.2328955|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0345716|    1| 0.8524962|
|Inverse variance weighted | 0.0796502|    2| 0.9609575|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|       0.0610807| 0.287686| 0.8668124|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        3.11e-05|              0|TRUE                     |    0.5968445|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/KANSL1AS1Conventional_Dendritic_Cell_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/KANSL1AS1Conventional_Dendritic_Cell_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/KANSL1AS1Conventional_Dendritic_Cell_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/KANSL1AS1Conventional_Dendritic_Cell_against_UKBb18436chunk8-1.png)
