

# Two sample MR report

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## SPATA20_Monocyte (Mono) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    6| 0.0671374| 0.0739351| 0.4152080|
|Weighted median           |    6| 0.0142632| 0.0070348| 0.0426099|
|Inverse variance weighted |    6| 0.0114819| 0.0057931| 0.0474798|
|Simple mode               |    6| 0.0157080| 0.0095911| 0.1623977|
|Weighted mode             |    6| 0.0156272| 0.0097986| 0.1716332|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.127617|    4| 0.8898661|
|Inverse variance weighted | 1.697767|    5| 0.8891810|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0497819| 0.0659291| 0.4922215|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0003267|              0|TRUE                     |     0.085343|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/SPATA20Monocyte_Mono_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/SPATA20Monocyte_Mono_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/SPATA20Monocyte_Mono_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/SPATA20Monocyte_Mono_against_UKBb18436chunk8-1.png)
