

# Two sample MR report

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## ZSWIM7_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   22|  0.0277817| 0.0478959| 0.5683639|
|Weighted median           |   22| -0.0122415| 0.0059696| 0.0403022|
|Inverse variance weighted |   22| -0.0113452| 0.0049233| 0.0212008|
|Simple mode               |   22| -0.0146392| 0.0101839| 0.1653175|
|Weighted mode             |   22| -0.0140180| 0.0106494| 0.2022549|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.432006|   20| 1.0000000|
|Inverse variance weighted | 2.106481|   21| 0.9999999|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|     pval|
|---------------:|--------:|--------:|
|      -0.0201859| 0.024579| 0.421178|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0004736|              0|TRUE                     |    0.0382857|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/ZSWIM7Epithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/ZSWIM7Epithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/ZSWIM7Epithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/ZSWIM7Epithelial_against_UKBb18436chunk8-1.png)
