

# Two sample MR report

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## CLEC4A_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3|  0.0382962| 0.2916030| 0.9168685|
|Weighted median           |    3| -0.0504493| 0.0235952| 0.0325074|
|Inverse variance weighted |    3| -0.0533945| 0.0182903| 0.0035083|
|Simple mode               |    3| -0.0482125| 0.0264390| 0.2097889|
|Weighted mode             |    3| -0.0483575| 0.0261516| 0.2056795|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 0.181779|    1| 0.6698489|
|Inverse variance weighted | 0.281040|    2| 0.8689063|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0355712| 0.1129039| 0.8056955|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        2.71e-05|              0|TRUE                     |    0.6233462|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/CLEC4AMacrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/CLEC4AMacrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/CLEC4AMacrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/CLEC4AMacrophages_against_UKBb18436chunk8-1.png)
