

# Two sample MR report

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## LY86_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    6| -0.0240763| 0.0419667| 0.5968865|
|Weighted median           |    6| -0.0366402| 0.0100374| 0.0002619|
|Inverse variance weighted |    6| -0.0391840| 0.0081964| 0.0000017|
|Simple mode               |    6| -0.0369732| 0.0128434| 0.0346383|
|Weighted mode             |    6| -0.0364846| 0.0128655| 0.0364239|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.2935301|    4| 0.9902280|
|Inverse variance weighted | 0.4282659|    5| 0.9945152|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0104149| 0.0283736| 0.7321659|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0003384|              0|TRUE                     |    0.0816795|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/LY86Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/LY86Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/LY86Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/LY86Macrophages_against_UKBb18436chunk8-1.png)
