

# Two sample MR report

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## HLA-DQA2_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |  102| 0.0504045| 0.0164619| 0.0028253|
|Weighted median           |  102| 0.0176484| 0.0028128| 0.0000000|
|Inverse variance weighted |  102| 0.0105008| 0.0022783| 0.0000040|
|Simple mode               |  102| 0.0230265| 0.0066572| 0.0007957|
|Weighted mode             |  102| 0.0223840| 0.0066310| 0.0010461|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 140.8558|  100| 0.0044664|
|Inverse variance weighted | 149.2860|  101| 0.0012836|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|       -0.029142| 0.011912| 0.0161735|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0017615|          1e-07|TRUE                     |     7.25e-05|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/HLADQA2Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/HLADQA2Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/HLADQA2Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/HLADQA2Macrophages_against_UKBb18436chunk8-1.png)
