

# Two sample MR report

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## ITGB3BP_Epithelial against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    5| -0.0001412| 0.0619658| 0.9983247|
|Weighted median           |    5| -0.0308444| 0.0170504| 0.0704500|
|Inverse variance weighted |    5| -0.0346232| 0.0144558| 0.0166155|
|Simple mode               |    5| -0.0317828| 0.0221754| 0.2250779|
|Weighted mode             |    5| -0.0298194| 0.0190408| 0.1923895|

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### Heterogeneity tests


|method                    |         Q| Q_df|   Q_pval|
|:-------------------------|---------:|----:|--------:|
|MR Egger                  | 0.4237681|    3| 0.935290|
|Inverse variance weighted | 0.7512467|    4| 0.944862|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0240961| 0.0421072| 0.6072191|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0002026|              0|TRUE                     |     0.176036|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/ITGB3BPEpithelial_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/ITGB3BPEpithelial_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/ITGB3BPEpithelial_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/ITGB3BPEpithelial_against_bbja88chunk8-1.png)
