

# Two sample MR report

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## ANXA5_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    5| 0.0206605| 0.1353427| 0.8883606|
|Weighted median           |    5| 0.0443360| 0.0182821| 0.0153038|
|Inverse variance weighted |    5| 0.0490317| 0.0152081| 0.0012639|
|Simple mode               |    5| 0.0448503| 0.0232961| 0.1265075|
|Weighted mode             |    5| 0.0449496| 0.0233976| 0.1271071|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.5713729|    3| 0.9029535|
|Inverse variance weighted | 0.6158771|    4| 0.9612831|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0107013| 0.0507264| 0.8464355|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        8.84e-05|              0|TRUE                     |    0.3742079|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/ANXA5Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/ANXA5Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/ANXA5Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/ANXA5Macrophages_against_UKBb18436chunk8-1.png)
