

# Two sample MR report

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## SULT2B1_Epithelial against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    4| -0.1448362| 0.9054645| 0.8876093|
|Weighted median           |    4| -0.0697601| 0.0208100| 0.0008016|
|Inverse variance weighted |    4| -0.0698202| 0.0170603| 0.0000427|
|Simple mode               |    4| -0.0660675| 0.0271103| 0.0927488|
|Weighted mode             |    4| -0.0732096| 0.0256200| 0.0647085|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0591239|    2| 0.9708707|
|Inverse variance weighted | 0.0659902|    3| 0.9955797|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0419046| 0.5057106| 0.9415075|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        6.63e-05|              0|TRUE                     |    0.4441959|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/SULT2B1Epithelial_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/SULT2B1Epithelial_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/SULT2B1Epithelial_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/SULT2B1Epithelial_against_bbja88chunk8-1.png)
