

# Two sample MR report

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## RPS26_Alveolar Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    6| -0.0466465| 0.0662267| 0.5200628|
|Weighted median           |    6| -0.0442801| 0.0097010| 0.0000050|
|Inverse variance weighted |    6| -0.0458127| 0.0076573| 0.0000000|
|Simple mode               |    6| -0.0429758| 0.0135259| 0.0246123|
|Weighted mode             |    6| -0.0428240| 0.0119454| 0.0157915|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.579875|    4| 0.8124046|
|Inverse variance weighted | 1.580035|    5| 0.9036530|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0005614| 0.0442883| 0.9904937|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0003693|          1e-07|TRUE                     |    0.0702715|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/RPS26Alveolar_Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/RPS26Alveolar_Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/RPS26Alveolar_Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/RPS26Alveolar_Macrophages_against_UKBb18436chunk8-1.png)
