

# Two sample MR report

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## PLA2G16_Endothelial Cell (Endo) against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3| -0.0612082| 0.2034799| 0.8139815|
|Weighted median           |    3| -0.0403614| 0.0165307| 0.0146222|
|Inverse variance weighted |    3| -0.0394445| 0.0136499| 0.0038557|
|Simple mode               |    3| -0.0411002| 0.0194031| 0.1683237|
|Weighted mode             |    3| -0.0412478| 0.0189932| 0.1620157|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0302397|    1| 0.8619475|
|Inverse variance weighted | 0.0417313|    2| 0.9793505|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0160581| 0.1497977| 0.9320147|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        7.43e-05|              0|TRUE                     |    0.4140459|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/PLA2G16Endothelial_Cell_Endo_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/PLA2G16Endothelial_Cell_Endo_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/PLA2G16Endothelial_Cell_Endo_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/PLA2G16Endothelial_Cell_Endo_against_bbja88chunk8-1.png)
