

# Two sample MR report

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## MTG2_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3| -0.0598505| 0.5039525| 0.9247461|
|Weighted median           |    3|  0.0243805| 0.0124673| 0.0505165|
|Inverse variance weighted |    3|  0.0236668| 0.0103923| 0.0227651|
|Simple mode               |    3|  0.0261200| 0.0142743| 0.2087627|
|Weighted mode             |    3|  0.0261962| 0.0154511| 0.2320811|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.2178477|    1| 0.6406848|
|Inverse variance weighted | 0.2453240|    2| 0.8845626|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0564662| 0.3406508| 0.8954248|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        4.44e-05|              0|TRUE                     |    0.5275606|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/MTG2Epithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/MTG2Epithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/MTG2Epithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/MTG2Epithelial_against_UKBb18436chunk8-1.png)
