

# Two sample MR report

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## SHTN1_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   10| 0.0263415| 0.0795393| 0.7490199|
|Weighted median           |   10| 0.0601598| 0.0122945| 0.0000010|
|Inverse variance weighted |   10| 0.0637234| 0.0089370| 0.0000000|
|Simple mode               |   10| 0.0610485| 0.0183921| 0.0089505|
|Weighted mode             |   10| 0.0594929| 0.0184557| 0.0104298|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 2.565518|    8| 0.9586057|
|Inverse variance weighted | 2.789224|    9| 0.9720685|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|        0.018266| 0.0386193| 0.6488663|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0002177|          1e-07|TRUE                     |    0.1666662|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/SHTN1Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/SHTN1Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/SHTN1Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/SHTN1Macrophages_against_UKBb18436chunk8-1.png)
