

# Two sample MR report

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## NUDT14_Endothelial Cell (Endo) against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3|  0.1841958| 0.7583994| 0.8483183|
|Weighted median           |    3| -0.0581923| 0.0226770| 0.0102839|
|Inverse variance weighted |    3| -0.0613288| 0.0165900| 0.0002184|
|Simple mode               |    3| -0.0575251| 0.0244526| 0.1429422|
|Weighted mode             |    3| -0.0575251| 0.0250007| 0.1480526|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0179594|    1| 0.8933924|
|Inverse variance weighted | 0.1228175|    2| 0.9404387|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       -0.138917| 0.4289972| 0.8006346|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        4.41e-05|              0|TRUE                     |    0.5324527|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/NUDT14Endothelial_Cell_Endo_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/NUDT14Endothelial_Cell_Endo_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/NUDT14Endothelial_Cell_Endo_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/NUDT14Endothelial_Cell_Endo_against_bbja88chunk8-1.png)
