

# Two sample MR report

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## SLC12A7_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   22| -0.0553972| 0.1079193| 0.6133509|
|Weighted median           |   22| -0.0436698| 0.0160394| 0.0064759|
|Inverse variance weighted |   22| -0.0398007| 0.0123915| 0.0013185|
|Simple mode               |   22| -0.0650374| 0.0283246| 0.0320600|
|Weighted mode             |   22| -0.0637676| 0.0295290| 0.0425285|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 7.746024|   20| 0.9934191|
|Inverse variance weighted | 7.767189|   21| 0.9960545|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0088381| 0.0607501| 0.8857862|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0006512|              0|TRUE                     |    0.0151896|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/SLC12A7Macrophages_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/SLC12A7Macrophages_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/SLC12A7Macrophages_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/SLC12A7Macrophages_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
