

# Two sample MR report

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## NUDT14_Epithelial against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    7| -0.1021016| 0.0729114| 0.2203052|
|Weighted median           |    7| -0.0498413| 0.0124740| 0.0000645|
|Inverse variance weighted |    7| -0.0481141| 0.0104329| 0.0000040|
|Simple mode               |    7| -0.0510649| 0.0190240| 0.0363307|
|Weighted mode             |    7| -0.0511954| 0.0179420| 0.0290524|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.2833717|    5| 0.9979442|
|Inverse variance weighted | 0.8431033|    6| 0.9908678|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0333597| 0.0445895| 0.4880439|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        0.000635|              0|TRUE                     |    0.0167389|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/NUDT14Epithelial_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/NUDT14Epithelial_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/NUDT14Epithelial_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/NUDT14Epithelial_against_bbja88chunk8-1.png)
