

# Two sample MR report

---

## CBWD1_Alveolar Macrophages against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

---

### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   11| -0.1459358| 0.0947242| 0.1577923|
|Weighted median           |   11| -0.0825632| 0.0142434| 0.0000000|
|Inverse variance weighted |   11| -0.0780234| 0.0110441| 0.0000000|
|Simple mode               |   11| -0.0852181| 0.0220456| 0.0031318|
|Weighted mode             |   11| -0.0847333| 0.0209653| 0.0023552|

---

### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.102371|    9| 0.9991631|
|Inverse variance weighted | 1.623471|   10| 0.9984966|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0601985| 0.0833921| 0.4887021|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0005565|          1e-07|TRUE                     |    0.0258872|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/CBWD1Alveolar_Macrophages_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/CBWD1Alveolar_Macrophages_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/CBWD1Alveolar_Macrophages_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/CBWD1Alveolar_Macrophages_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
