

# Two sample MR report

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## BAIAP3_Epithelial against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    5| -0.5833526| 0.2944181| 0.1418677|
|Weighted median           |    5| -0.1521484| 0.0671214| 0.0234046|
|Inverse variance weighted |    5| -0.1638985| 0.0517305| 0.0015332|
|Simple mode               |    5| -0.2306029| 0.0990846| 0.0804869|
|Weighted mode             |    5| -0.0905236| 0.0988579| 0.4116371|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.7924349|    3| 0.8512756|
|Inverse variance weighted | 2.8868304|    4| 0.5769392|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.2431182| 0.1679918| 0.2436465|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        3.46e-05|              0|TRUE                     |     0.579526|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/BAIAP3Epithelial_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/BAIAP3Epithelial_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/BAIAP3Epithelial_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/BAIAP3Epithelial_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
