

# Two sample MR report

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## RPS26_Endothelial Cell (Endo) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    6|  0.0026096| 0.0365155| 0.9464582|
|Weighted median           |    6| -0.0427168| 0.0123142| 0.0005226|
|Inverse variance weighted |    6| -0.0505591| 0.0095332| 0.0000001|
|Simple mode               |    6| -0.0423315| 0.0179859| 0.0652678|
|Weighted mode             |    6| -0.0403128| 0.0151022| 0.0443837|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.725029|    4| 0.7861662|
|Inverse variance weighted | 4.000210|    5| 0.5493858|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       -0.028356| 0.0187991| 0.2059533|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0003983|              0|TRUE                     |    0.0598399|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/RPS26Endothelial_Cell_Endo_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/RPS26Endothelial_Cell_Endo_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/RPS26Endothelial_Cell_Endo_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/RPS26Endothelial_Cell_Endo_against_UKBb18436chunk8-1.png)
