

# Two sample MR report

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## TTC32_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    5| 0.1904649| 0.2173907| 0.4454480|
|Weighted median           |    5| 0.0288815| 0.0146364| 0.0484658|
|Inverse variance weighted |    5| 0.0271135| 0.0112590| 0.0160328|
|Simple mode               |    5| 0.0292726| 0.0184432| 0.1876632|
|Weighted mode             |    5| 0.0291152| 0.0184492| 0.1896761|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.320453|    3| 0.7242820|
|Inverse variance weighted | 1.886602|    4| 0.7566059|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|      -0.1426047| 0.189526| 0.5064501|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        9.74e-05|              0|TRUE                     |     0.349129|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/TTC32Epithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/TTC32Epithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/TTC32Epithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/TTC32Epithelial_against_UKBb18436chunk8-1.png)
