

# Two sample MR report

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## RPS26_Interstitial Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    4| -0.0662173| 0.2022718| 0.7744793|
|Weighted median           |    4| -0.0593497| 0.0132117| 0.0000070|
|Inverse variance weighted |    4| -0.0602588| 0.0114372| 0.0000001|
|Simple mode               |    4| -0.0581939| 0.0174036| 0.0442630|
|Weighted mode             |    4| -0.0582513| 0.0177292| 0.0462303|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0556910|    2| 0.9725386|
|Inverse variance weighted | 0.0565616|    3| 0.9964824|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0031007| 0.1050906| 0.9791412|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0002024|              0|TRUE                     |    0.1808611|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/RPS26Interstitial_Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/RPS26Interstitial_Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/RPS26Interstitial_Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/RPS26Interstitial_Macrophages_against_UKBb18436chunk8-1.png)
