

# Two sample MR report

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## RRP7A_Monocyte (Mono) against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   14| -0.0367516| 0.1940979| 0.8529866|
|Weighted median           |   14| -0.0883418| 0.0197828| 0.0000080|
|Inverse variance weighted |   14| -0.0653068| 0.0189405| 0.0005647|
|Simple mode               |   14| -0.0901931| 0.0272365| 0.0056222|
|Weighted mode             |   14| -0.0896037| 0.0264276| 0.0048294|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 22.85366|   12| 0.0289943|
|Inverse variance weighted | 22.89531|   13| 0.0429499|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0218947| 0.1480563| 0.8848927|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0003062|              0|TRUE                     |    0.0978363|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/RRP7AMonocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/RRP7AMonocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/RRP7AMonocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/RRP7AMonocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
