

# Two sample MR report

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## SLFN5_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    3| 0.1471867| 0.4488694| 0.7982822|
|Weighted median           |    3| 0.0458262| 0.0190257| 0.0160117|
|Inverse variance weighted |    3| 0.0466313| 0.0149819| 0.0018551|
|Simple mode               |    3| 0.0446308| 0.0215083| 0.1736622|
|Weighted mode             |    3| 0.0447461| 0.0212856| 0.1702824|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0143609|    1| 0.9046123|
|Inverse variance weighted | 0.0646016|    2| 0.9682153|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0468272| 0.2089157| 0.8596255|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        3.12e-05|              0|TRUE                     |    0.6004049|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/SLFN5Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/SLFN5Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/SLFN5Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/SLFN5Macrophages_against_UKBb18436chunk8-1.png)
