

# Two sample MR report

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## HLA-C_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   14|  0.0685706| 0.0441260| 0.1461566|
|Weighted median           |   14| -0.0346190| 0.0117220| 0.0031436|
|Inverse variance weighted |   14| -0.0353999| 0.0117591| 0.0026089|
|Simple mode               |   14| -0.0536871| 0.0209779| 0.0237741|
|Weighted mode             |   14| -0.0313633| 0.0166931| 0.0828749|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 19.58708|   12| 0.0753114|
|Inverse variance weighted | 29.14308|   13| 0.0062467|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0487296| 0.0201395| 0.0323409|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0002582|              0|TRUE                     |    0.1300353|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/HLACEpithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/HLACEpithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/HLACEpithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/HLACEpithelial_against_UKBb18436chunk8-1.png)
