

# Two sample MR report

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## RPS26_T Proliferating against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    6| -0.0285211| 0.1011968| 0.7920481|
|Weighted median           |    6| -0.0594184| 0.0127103| 0.0000029|
|Inverse variance weighted |    6| -0.0548041| 0.0100307| 0.0000000|
|Simple mode               |    6| -0.0640142| 0.0185054| 0.0180576|
|Weighted mode             |    6| -0.0622708| 0.0172838| 0.0154967|

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### Heterogeneity tests


|method                    |        Q| Q_df|   Q_pval|
|:-------------------------|--------:|----:|--------:|
|MR Egger                  | 1.879205|    4| 0.757964|
|Inverse variance weighted | 1.947329|    5| 0.856384|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0129081| 0.0494551| 0.8069744|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0003666|              0|TRUE                     |    0.0708448|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/RPS26T_Proliferating_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/RPS26T_Proliferating_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/RPS26T_Proliferating_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/RPS26T_Proliferating_against_UKBb18436chunk8-1.png)
