

# Two sample MR report

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## SIRPB1_Monocyte (Mono) against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    4| -0.4336182| 0.2657571| 0.2443410|
|Weighted median           |    4| -0.0823496| 0.0349278| 0.0183880|
|Inverse variance weighted |    4| -0.0643879| 0.0284418| 0.0235837|
|Simple mode               |    4| -0.0816822| 0.0492329| 0.1956781|
|Weighted mode             |    4| -0.0889962| 0.0417626| 0.1228945|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.6035169|    2| 0.7395167|
|Inverse variance weighted | 2.5561818|    3| 0.4652233|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.2237792| 0.1601422| 0.2971399|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001245|              0|TRUE                     |    0.2901384|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/SIRPB1Monocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/SIRPB1Monocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/SIRPB1Monocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/SIRPB1Monocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
