

# Two sample MR report

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## RPS26_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   21| -0.0476651| 0.0337321| 0.1738142|
|Weighted median           |   21| -0.0736058| 0.0094962| 0.0000000|
|Inverse variance weighted |   21| -0.0715624| 0.0064741| 0.0000000|
|Simple mode               |   21| -0.0862106| 0.0195422| 0.0002689|
|Weighted mode             |   21| -0.0826276| 0.0159226| 0.0000445|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 17.37357|   19| 0.5645754|
|Inverse variance weighted | 17.89466|   20| 0.5943477|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|     pval|
|---------------:|---------:|--------:|
|      -0.0115709| 0.0160291| 0.479168|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0010062|          2e-07|TRUE                     |    0.0028169|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/RPS26Epithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/RPS26Epithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/RPS26Epithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/RPS26Epithelial_against_UKBb18436chunk8-1.png)
