

# Two sample MR report

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## SH3YL1_Epithelial against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   11| -0.1771058| 0.1220652| 0.1807487|
|Weighted median           |   11| -0.0482816| 0.0131667| 0.0002455|
|Inverse variance weighted |   11| -0.0335581| 0.0122898| 0.0063227|
|Simple mode               |   11| -0.0507032| 0.0176283| 0.0164916|
|Weighted mode             |   11| -0.0484168| 0.0175433| 0.0201353|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 14.15510|    9| 0.1169141|
|Inverse variance weighted | 16.35161|   10| 0.0899998|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|        0.084525| 0.0715242| 0.2675808|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0002328|              0|TRUE                     |     0.149435|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/SH3YL1Epithelial_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/SH3YL1Epithelial_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/SH3YL1Epithelial_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/SH3YL1Epithelial_against_bbja88chunk8-1.png)
