

# Two sample MR report

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## C4orf22_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   16| -0.1412036| 0.1062475| 0.2050998|
|Weighted median           |   16|  0.0110861| 0.0126369| 0.3803351|
|Inverse variance weighted |   16|  0.0177387| 0.0089139| 0.0465914|
|Simple mode               |   16|  0.0459881| 0.0223639| 0.0575804|
|Weighted mode             |   16|  0.0105682| 0.0223601| 0.6432776|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 13.11507|   14| 0.5174839|
|Inverse variance weighted | 15.36845|   15| 0.4252170|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0647494| 0.0431338| 0.1555366|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001792|              0|TRUE                     |    0.2043851|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/C4orf22Epithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/C4orf22Epithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/C4orf22Epithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/C4orf22Epithelial_against_UKBb18436chunk8-1.png)
