

# Two sample MR report

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## C1orf189_T Proliferating against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    3| 0.0132766| 0.0784946| 0.8933315|
|Weighted median           |    3| 0.0300845| 0.0093837| 0.0013457|
|Inverse variance weighted |    3| 0.0310575| 0.0072566| 0.0000187|
|Simple mode               |    3| 0.0300658| 0.0100313| 0.0956206|
|Weighted mode             |    3| 0.0300658| 0.0103252| 0.1004762|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0000102|    1| 0.9974515|
|Inverse variance weighted | 0.0517653|    2| 0.9744494|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|       0.0308575| 0.135639| 0.8575944|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        2.95e-05|              0|TRUE                     |    0.6116423|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/C1orf189T_Proliferating_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/C1orf189T_Proliferating_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/C1orf189T_Proliferating_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/C1orf189T_Proliferating_against_bbja88chunk8-1.png)
