

# Two sample MR report

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## ERP27_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   21| -0.0047021| 0.0152583| 0.7613074|
|Weighted median           |   21|  0.0111385| 0.0053900| 0.0387782|
|Inverse variance weighted |   21|  0.0100700| 0.0040936| 0.0138955|
|Simple mode               |   21|  0.0194944| 0.0092064| 0.0469438|
|Weighted mode             |   21|  0.0119590| 0.0084568| 0.1727032|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 8.032739|   19| 0.9863384|
|Inverse variance weighted | 9.042717|   20| 0.9824072|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0101767| 0.0101263| 0.3275362|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0013148|              0|TRUE                     |    0.0005522|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/ERP27Epithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/ERP27Epithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/ERP27Epithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/ERP27Epithelial_against_UKBb18436chunk8-1.png)
