

# Two sample MR report

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## C19orf60_Monocyte (Mono) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    4| 0.0654688| 0.3765809| 0.8779876|
|Weighted median           |    4| 0.0297358| 0.0155632| 0.0560497|
|Inverse variance weighted |    4| 0.0283062| 0.0135230| 0.0363328|
|Simple mode               |    4| 0.0309688| 0.0201189| 0.2213623|
|Weighted mode             |    4| 0.0311743| 0.0194189| 0.2067611|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.1034580|    2| 0.9495862|
|Inverse variance weighted | 0.1132091|    3| 0.9902065|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0163717| 0.1657929| 0.9303443|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        6.83e-05|              0|TRUE                     |    0.4321479|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/C19orf60Monocyte_Mono_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/C19orf60Monocyte_Mono_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/C19orf60Monocyte_Mono_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/C19orf60Monocyte_Mono_against_UKBb18436chunk8-1.png)
