

# Two sample MR report

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## HP_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   12| -0.0135429| 0.0569722| 0.8169054|
|Weighted median           |   12|  0.0115125| 0.0065454| 0.0786004|
|Inverse variance weighted |   12|  0.0111677| 0.0051400| 0.0298025|
|Simple mode               |   12|  0.0031245| 0.0131099| 0.8160059|
|Weighted mode             |   12|  0.0191631| 0.0108574| 0.1052763|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 13.55552|   10| 0.1942476|
|Inverse variance weighted | 13.81279|   11| 0.2435261|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0209314| 0.0480465| 0.6723451|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0006392|              0|TRUE                     |    0.0164899|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/HPMacrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/HPMacrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/HPMacrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/HPMacrophages_against_UKBb18436chunk8-1.png)
