

# Two sample MR report

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## LILRA2_Monocyte (Mono) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    7| 0.1371283| 0.1217906| 0.3113141|
|Weighted median           |    7| 0.0531391| 0.0192905| 0.0058750|
|Inverse variance weighted |    7| 0.0398014| 0.0138957| 0.0041793|
|Simple mode               |    7| 0.0600190| 0.0278603| 0.0746637|
|Weighted mode             |    7| 0.0591119| 0.0266866| 0.0686656|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 2.660513|    5| 0.7521508|
|Inverse variance weighted | 3.307551|    6| 0.7693728|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|     pval|
|---------------:|---------:|--------:|
|      -0.0511881| 0.0636362| 0.457698|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001125|              0|TRUE                     |    0.3150806|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/LILRA2Monocyte_Mono_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/LILRA2Monocyte_Mono_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/LILRA2Monocyte_Mono_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/LILRA2Monocyte_Mono_against_UKBb18436chunk8-1.png)
