

# Two sample MR report

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## TUFM_Monocyte (Mono) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   18| 0.0077099| 0.0515913| 0.8830721|
|Weighted median           |   18| 0.0393414| 0.0080297| 0.0000010|
|Inverse variance weighted |   18| 0.0373468| 0.0061452| 0.0000000|
|Simple mode               |   18| 0.0463816| 0.0133347| 0.0028764|
|Weighted mode             |   18| 0.0373314| 0.0117851| 0.0056252|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 13.31855|   16| 0.6493395|
|Inverse variance weighted | 13.65330|   17| 0.6914737|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|       0.0140113| 0.024217| 0.5709322|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0004067|              0|TRUE                     |    0.0565145|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/TUFMMonocyte_Mono_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/TUFMMonocyte_Mono_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/TUFMMonocyte_Mono_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/TUFMMonocyte_Mono_against_UKBb18436chunk8-1.png)
