

# Two sample MR report

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## NAGK_Conventional Dendritic Cell against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    4| -0.1846003| 0.2559346| 0.5456587|
|Weighted median           |    4| -0.0478285| 0.0192863| 0.0131412|
|Inverse variance weighted |    4| -0.0409793| 0.0157996| 0.0094950|
|Simple mode               |    4| -0.0514407| 0.0277803| 0.1611530|
|Weighted mode             |    4| -0.0503579| 0.0257348| 0.1453051|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 2.243446|    2| 0.3257181|
|Inverse variance weighted | 2.598198|    3| 0.4578056|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0832393| 0.1480162| 0.6304901|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|           8e-05|              0|TRUE                     |    0.3971604|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/NAGKConventional_Dendritic_Cell_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/NAGKConventional_Dendritic_Cell_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/NAGKConventional_Dendritic_Cell_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/NAGKConventional_Dendritic_Cell_against_bbja88chunk8-1.png)
