

# Two sample MR report

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## CD55_Monocyte (Mono) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    4| 0.0999042| 0.1782520| 0.6315690|
|Weighted median           |    4| 0.0540351| 0.0159395| 0.0006989|
|Inverse variance weighted |    4| 0.0526830| 0.0141530| 0.0001973|
|Simple mode               |    4| 0.0547865| 0.0223809| 0.0918497|
|Weighted mode             |    4| 0.0546504| 0.0209289| 0.0795998|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.1066825|    2| 0.9480564|
|Inverse variance weighted | 0.1773064|    3| 0.9811669|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|         -0.0205| 0.0771396| 0.8153177|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001703|              0|TRUE                     |    0.2168476|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/CD55Monocyte_Mono_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/CD55Monocyte_Mono_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/CD55Monocyte_Mono_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/CD55Monocyte_Mono_against_UKBb18436chunk8-1.png)
