

# Two sample MR report

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## ADK_Epithelial against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    4| 0.0019376| 0.4126490| 0.9966797|
|Weighted median           |    4| 0.0366466| 0.0196696| 0.0624466|
|Inverse variance weighted |    4| 0.0367466| 0.0172251| 0.0328993|
|Simple mode               |    4| 0.0365035| 0.0269456| 0.2685019|
|Weighted mode             |    4| 0.0360771| 0.0261678| 0.2618097|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0031977|    2| 0.9984024|
|Inverse variance weighted | 0.0103258|    3| 0.9997218|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0166298| 0.1969688| 0.9404062|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        2.49e-05|              0|TRUE                     |    0.6359976|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/ADKEpithelial_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/ADKEpithelial_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/ADKEpithelial_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/ADKEpithelial_against_bbja88chunk8-1.png)
