

# Two sample MR report

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## DYDC2_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   10|  0.0224578| 0.0815101| 0.7898984|
|Weighted median           |   10| -0.0437784| 0.0099089| 0.0000100|
|Inverse variance weighted |   10| -0.0476336| 0.0074726| 0.0000000|
|Simple mode               |   10| -0.0437123| 0.0138445| 0.0115991|
|Weighted mode             |   10| -0.0437123| 0.0140755| 0.0126089|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.105607|    8| 0.9974891|
|Inverse variance weighted | 1.851321|    9| 0.9936064|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       -0.035343| 0.0409278| 0.4129765|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0002295|              0|TRUE                     |    0.1534142|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/DYDC2Epithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/DYDC2Epithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/DYDC2Epithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/DYDC2Epithelial_against_UKBb18436chunk8-1.png)
