

# Two sample MR report

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## PLA2G16_Epithelial against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    5| -0.0123818| 0.1339522| 0.9321798|
|Weighted median           |    5| -0.0567183| 0.0200843| 0.0047426|
|Inverse variance weighted |    5| -0.0612033| 0.0159559| 0.0001252|
|Simple mode               |    5| -0.0558812| 0.0248807| 0.0880378|
|Weighted mode             |    5| -0.0560213| 0.0241041| 0.0807690|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.1769159|    3| 0.9812269|
|Inverse variance weighted | 0.3116658|    4| 0.9890487|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0241158| 0.0656957| 0.7379224|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        6.11e-05|              0|TRUE                     |    0.4609196|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/PLA2G16Epithelial_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/PLA2G16Epithelial_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/PLA2G16Epithelial_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/PLA2G16Epithelial_against_bbja88chunk8-1.png)
