

# Two sample MR report

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## NAGK_Monocyte (Mono) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    7| 0.0591215| 0.1176514| 0.6366510|
|Weighted median           |    7| 0.0393236| 0.0164189| 0.0166194|
|Inverse variance weighted |    7| 0.0277575| 0.0140452| 0.0481207|
|Simple mode               |    7| 0.0410316| 0.0220909| 0.1126297|
|Weighted mode             |    7| 0.0388470| 0.0190317| 0.0873025|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 7.538645|    5| 0.1835618|
|Inverse variance weighted | 7.647632|    6| 0.2650716|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0153797| 0.0572034| 0.7987783|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        5.85e-05|              0|TRUE                     |    0.4690284|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/NAGKMonocyte_Mono_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/NAGKMonocyte_Mono_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/NAGKMonocyte_Mono_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/NAGKMonocyte_Mono_against_UKBb18436chunk8-1.png)
