

# Two sample MR report

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## SOD1_Epithelial against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3| -0.0290014| 0.6535595| 0.9717689|
|Weighted median           |    3|  0.0440405| 0.0222944| 0.0482225|
|Inverse variance weighted |    3|  0.0454444| 0.0180837| 0.0119710|
|Simple mode               |    3|  0.0429242| 0.0255889| 0.2354530|
|Weighted mode             |    3|  0.0427567| 0.0252609| 0.2326072|

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### Heterogeneity tests


|method                    |         Q| Q_df|   Q_pval|
|:-------------------------|---------:|----:|--------:|
|MR Egger                  | 0.0400397|    1| 0.841403|
|Inverse variance weighted | 0.0530247|    2| 0.973836|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0380874| 0.3342415| 0.9277676|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        2.56e-05|              0|TRUE                     |    0.6328099|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/SOD1Epithelial_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/SOD1Epithelial_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/SOD1Epithelial_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/SOD1Epithelial_against_bbja88chunk8-1.png)
