

# Two sample MR report

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## WDR91_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    3| 0.0605697| 0.1115833| 0.6833998|
|Weighted median           |    3| 0.0335450| 0.0140355| 0.0168479|
|Inverse variance weighted |    3| 0.0298929| 0.0117145| 0.0107173|
|Simple mode               |    3| 0.0347368| 0.0165322| 0.1704071|
|Weighted mode             |    3| 0.0347016| 0.0171140| 0.1797895|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.2907830|    1| 0.5897192|
|Inverse variance weighted | 0.3672079|    2| 0.8322653|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0195491| 0.0707145| 0.8282945|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        8.01e-05|              0|TRUE                     |    0.3969027|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/WDR91Epithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/WDR91Epithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/WDR91Epithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/WDR91Epithelial_against_UKBb18436chunk8-1.png)
