

# Two sample MR report

---

## BICDL2_Endothelial Cell (Endo) against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

---

### Results from two sample MR:


|method                    | nsnp|         b|         se|      pval|
|:-------------------------|----:|---------:|----------:|---------:|
|MR Egger                  |    3| 1.8443069| 11.2213954| 0.8962947|
|Weighted median           |    3| 0.0655321|  0.0355168| 0.0650229|
|Inverse variance weighted |    3| 0.0624935|  0.0288731| 0.0304325|
|Simple mode               |    3| 0.0663373|  0.0383223| 0.2255849|
|Weighted mode             |    3| 0.0663050|  0.0375340| 0.2193441|

---

### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0088549|    1| 0.9250294|
|Inverse variance weighted | 0.0340684|    2| 0.9831101|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|       -1.252644| 7.888797| 0.8997496|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        2.26e-05|              0|TRUE                     |    0.6522948|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/BICDL2Endothelial_Cell_Endo_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/BICDL2Endothelial_Cell_Endo_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/BICDL2Endothelial_Cell_Endo_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/BICDL2Endothelial_Cell_Endo_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
