

# Two sample MR report

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## PARK7_T Proliferating against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    3| 0.8968624| 1.8640940| 0.7145181|
|Weighted median           |    3| 0.1702956| 0.0809252| 0.0353472|
|Inverse variance weighted |    3| 0.1594496| 0.0626090| 0.0108731|
|Simple mode               |    3| 0.1817505| 0.0903350| 0.1818855|
|Weighted mode             |    3| 0.1807663| 0.0871723| 0.1738375|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.1768677|    1| 0.6740791|
|Inverse variance weighted | 0.3335341|    2| 0.8463968|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.2192477| 0.5539201| 0.7600643|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        3.38e-05|              0|TRUE                     |    0.5826937|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/PARK7T_Proliferating_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/PARK7T_Proliferating_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/PARK7T_Proliferating_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/PARK7T_Proliferating_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
