

# Two sample MR report

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## TFF3_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    4| -0.0038953| 0.0975595| 0.9717784|
|Weighted median           |    4| -0.0343347| 0.0146608| 0.0191838|
|Inverse variance weighted |    4| -0.0306659| 0.0122818| 0.0125299|
|Simple mode               |    4| -0.0359739| 0.0193706| 0.1602847|
|Weighted mode             |    4| -0.0364064| 0.0192598| 0.1551125|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.3279558|    2| 0.8487608|
|Inverse variance weighted | 0.4044655|    3| 0.9393185|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0142872| 0.0516522| 0.8080486|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        6.85e-05|              0|TRUE                     |    0.4327884|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/TFF3Epithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/TFF3Epithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/TFF3Epithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/TFF3Epithelial_against_UKBb18436chunk8-1.png)
