

# Two sample MR report

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## SULT1A1_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    4| -0.2144453| 0.2651908| 0.5036191|
|Weighted median           |    4| -0.0365380| 0.0150412| 0.0151326|
|Inverse variance weighted |    4| -0.0321987| 0.0121225| 0.0079047|
|Simple mode               |    4| -0.0368697| 0.0194741| 0.1546541|
|Weighted mode             |    4| -0.0368148| 0.0189450| 0.1472424|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0759288|    2| 0.9627472|
|Inverse variance weighted | 0.5492000|    3| 0.9079568|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0931055| 0.1353382| 0.5625593|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        6.03e-05|              0|TRUE                     |      0.46207|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/SULT1A1Epithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/SULT1A1Epithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/SULT1A1Epithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/SULT1A1Epithelial_against_UKBb18436chunk8-1.png)
