

# Two sample MR report

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## SETD9_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    7| -0.1815208| 0.2974949| 0.5684176|
|Weighted median           |    7|  0.1008827| 0.0319068| 0.0015680|
|Inverse variance weighted |    7|  0.0749609| 0.0274547| 0.0063267|
|Simple mode               |    7|  0.1057868| 0.0438494| 0.0523952|
|Weighted mode             |    7|  0.1042201| 0.0444405| 0.0574370|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 6.437690|    5| 0.2659275|
|Inverse variance weighted | 7.403275|    6| 0.2851561|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.1569262| 0.1812092| 0.4260864|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        7.43e-05|              0|TRUE                     |    0.4151648|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/SETD9Macrophages_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/SETD9Macrophages_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/SETD9Macrophages_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/SETD9Macrophages_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
