

# Two sample MR report

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## MGP_Endothelial Cell (Endo) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    6| 0.0086366| 0.1601041| 0.9595667|
|Weighted median           |    6| 0.0234678| 0.0111858| 0.0359053|
|Inverse variance weighted |    6| 0.0228622| 0.0094191| 0.0152149|
|Simple mode               |    6| 0.0246649| 0.0154791| 0.1719436|
|Weighted mode             |    6| 0.0245342| 0.0149569| 0.1618621|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0453782|    4| 0.9997465|
|Inverse variance weighted | 0.0533003|    5| 0.9999658|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0074869| 0.0841164| 0.9333551|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|         8.9e-05|              0|TRUE                     |    0.3698304|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/MGPEndothelial_Cell_Endo_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/MGPEndothelial_Cell_Endo_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/MGPEndothelial_Cell_Endo_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/MGPEndothelial_Cell_Endo_against_UKBb18436chunk8-1.png)
