

# Two sample MR report

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## HLA-DQB1_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   26| -0.0274200| 0.0368654| 0.4642250|
|Weighted median           |   26|  0.0293512| 0.0071903| 0.0000446|
|Inverse variance weighted |   26|  0.0282576| 0.0059006| 0.0000017|
|Simple mode               |   26|  0.0005598| 0.0185075| 0.9761096|
|Weighted mode             |   26|  0.0016934| 0.0158689| 0.9158705|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 35.42521|   24| 0.0623400|
|Inverse variance weighted | 38.87598|   25| 0.0379075|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|       0.0323445| 0.021154| 0.1393387|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0004659|          1e-07|TRUE                     |    0.0426357|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/HLADQB1Epithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/HLADQB1Epithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/HLADQB1Epithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/HLADQB1Epithelial_against_UKBb18436chunk8-1.png)
