

# Two sample MR report

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## CBWD1_Endothelial Cell (Endo) against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    6|  0.0244583| 0.1625945| 0.8877101|
|Weighted median           |    6| -0.0767955| 0.0160650| 0.0000018|
|Inverse variance weighted |    6| -0.0777099| 0.0128194| 0.0000000|
|Simple mode               |    6| -0.0769979| 0.0219822| 0.0172340|
|Weighted mode             |    6| -0.0767573| 0.0201926| 0.0126121|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.1169984|    4| 0.9983542|
|Inverse variance weighted | 0.5143066|    5| 0.9915901|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.1037314| 0.1645684| 0.5626988|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001815|              0|TRUE                     |    0.2041721|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/CBWD1Endothelial_Cell_Endo_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/CBWD1Endothelial_Cell_Endo_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/CBWD1Endothelial_Cell_Endo_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/CBWD1Endothelial_Cell_Endo_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
