

# Two sample MR report

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## HLA-DQB1_Monocyte (Mono) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   26| -0.0657930| 0.0699343| 0.3561898|
|Weighted median           |   26|  0.0757056| 0.0133954| 0.0000000|
|Inverse variance weighted |   26|  0.0794609| 0.0116007| 0.0000000|
|Simple mode               |   26|  0.1244650| 0.0355830| 0.0017749|
|Weighted mode             |   26|  0.1152433| 0.0387914| 0.0064756|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 42.82838|   24| 0.0104053|
|Inverse variance weighted | 50.71763|   25| 0.0017367|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0457372| 0.0217526| 0.0461723|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0003633|          2e-07|TRUE                     |    0.0755873|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/HLADQB1Monocyte_Mono_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/HLADQB1Monocyte_Mono_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/HLADQB1Monocyte_Mono_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/HLADQB1Monocyte_Mono_against_UKBb18436chunk8-1.png)
