

# Two sample MR report

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## HLA-A_Conventional Dendritic Cell against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   38| -0.0092582| 0.0469144| 0.8446691|
|Weighted median           |   38|  0.0447610| 0.0050097| 0.0000000|
|Inverse variance weighted |   38|  0.0425039| 0.0036321| 0.0000000|
|Simple mode               |   38|  0.0486842| 0.0098585| 0.0000171|
|Weighted mode             |   38|  0.0472205| 0.0095049| 0.0000156|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 18.96790|   36| 0.9912120|
|Inverse variance weighted | 20.19258|   37| 0.9888546|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0287993| 0.0260238| 0.2757846|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        0.000846|          1e-07|TRUE                     |    0.0061723|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/HLAAConventional_Dendritic_Cell_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/HLAAConventional_Dendritic_Cell_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/HLAAConventional_Dendritic_Cell_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/HLAAConventional_Dendritic_Cell_against_UKBb18436chunk8-1.png)
