

# Two sample MR report

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## PRUNE2_Alveolar Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    7| 0.0457194| 0.0377925| 0.2804468|
|Weighted median           |    7| 0.0157623| 0.0062135| 0.0111881|
|Inverse variance weighted |    7| 0.0130681| 0.0050928| 0.0102872|
|Simple mode               |    7| 0.0169359| 0.0084868| 0.0929950|
|Weighted mode             |    7| 0.0169359| 0.0086179| 0.0969931|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.431046|    5| 0.9208872|
|Inverse variance weighted | 2.191279|    6| 0.9012929|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0353584| 0.0405526| 0.4231398|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001706|              0|TRUE                     |    0.2149077|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/PRUNE2Alveolar_Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/PRUNE2Alveolar_Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/PRUNE2Alveolar_Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/PRUNE2Alveolar_Macrophages_against_UKBb18436chunk8-1.png)
