

# Two sample MR report

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## ZNF880_Alveolar Macrophages against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    6| -0.0806149| 0.1482336| 0.6154465|
|Weighted median           |    6| -0.0474844| 0.0151200| 0.0016865|
|Inverse variance weighted |    6| -0.0400811| 0.0117625| 0.0006555|
|Simple mode               |    6| -0.0484457| 0.0210083| 0.0692496|
|Weighted mode             |    6| -0.0484457| 0.0197659| 0.0578671|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.498478|    4| 0.8269110|
|Inverse variance weighted | 1.573724|    5| 0.9044085|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0284074| 0.1035596| 0.7974303|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        6.85e-05|              0|TRUE                     |    0.4341652|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/ZNF880Alveolar_Macrophages_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/ZNF880Alveolar_Macrophages_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/ZNF880Alveolar_Macrophages_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/ZNF880Alveolar_Macrophages_against_bbja88chunk8-1.png)
