

# Two sample MR report

---

## HLA-DRB5_T Proliferating against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

---

### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   28| 0.0508349| 0.0729281| 0.4919541|
|Weighted median           |   28| 0.0561181| 0.0209070| 0.0072710|
|Inverse variance weighted |   28| 0.0583123| 0.0156723| 0.0001987|
|Simple mode               |   28| 0.0903524| 0.0408138| 0.0354790|
|Weighted mode             |   28| 0.0665311| 0.0397120| 0.1054130|

---

### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 7.082174|   26| 0.9999148|
|Inverse variance weighted | 7.093196|   27| 0.9999566|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0034026| 0.0324105| 0.9171939|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        0.000476|              0|TRUE                     |    0.0381008|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/HLADRB5T_Proliferating_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/HLADRB5T_Proliferating_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/HLADRB5T_Proliferating_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/HLADRB5T_Proliferating_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
