

# Two sample MR report

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## IRF5_Dendritic Cell (DC) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    3| 0.4018604| 1.3986490| 0.8218840|
|Weighted median           |    3| 0.0434670| 0.0209229| 0.0377569|
|Inverse variance weighted |    3| 0.0395565| 0.0165038| 0.0165384|
|Simple mode               |    3| 0.0464099| 0.0246527| 0.2004698|
|Weighted mode             |    3| 0.0463291| 0.0217855| 0.1673141|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.2638770|    1| 0.6074690|
|Inverse variance weighted | 0.3309873|    2| 0.8474753|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|     pval|
|---------------:|---------:|--------:|
|      -0.1527424| 0.5896105| 0.838627|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        2.87e-05|              0|TRUE                     |     0.612406|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/IRF5Dendritic_Cell_DC_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/IRF5Dendritic_Cell_DC_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/IRF5Dendritic_Cell_DC_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/IRF5Dendritic_Cell_DC_against_UKBb18436chunk8-1.png)
