

# Two sample MR report

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## THBS1_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    9|  0.1214481| 0.3597848| 0.7455930|
|Weighted median           |    9| -0.0613700| 0.0202422| 0.0024312|
|Inverse variance weighted |    9| -0.0475189| 0.0152968| 0.0018934|
|Simple mode               |    9| -0.0623263| 0.0311531| 0.0804357|
|Weighted mode             |    9| -0.0623263| 0.0302717| 0.0734859|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 5.427656|    7| 0.6079237|
|Inverse variance weighted | 5.648611|    8| 0.6865254|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0444335| 0.0945276| 0.6526056|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        0.000133|              0|TRUE                     |    0.2753302|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/THBS1Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/THBS1Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/THBS1Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/THBS1Macrophages_against_UKBb18436chunk8-1.png)
