

# Two sample MR report

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## ARL16_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    9| -0.0582185| 0.1623743| 0.7305052|
|Weighted median           |    9| -0.0679796| 0.0218232| 0.0018394|
|Inverse variance weighted |    9| -0.0655619| 0.0174786| 0.0001761|
|Simple mode               |    9| -0.0765514| 0.0314657| 0.0410194|
|Weighted mode             |    9| -0.0762001| 0.0341874| 0.0563944|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.8103479|    7| 0.9973369|
|Inverse variance weighted | 0.8124172|    8| 0.9991785|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0058993| 0.1296829| 0.9649874|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001808|              0|TRUE                     |    0.2020017|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/ARL16Macrophages_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/ARL16Macrophages_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/ARL16Macrophages_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/ARL16Macrophages_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
