

# Two sample MR report

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## ZSWIM7_Dendritic Cell (DC) against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    4|  0.4462290| 0.7430060| 0.6091175|
|Weighted median           |    4| -0.1028961| 0.0364667| 0.0047778|
|Inverse variance weighted |    4| -0.1091138| 0.0298192| 0.0002530|
|Simple mode               |    4| -0.0893213| 0.0496668| 0.1699500|
|Weighted mode             |    4| -0.0886496| 0.0479021| 0.1613219|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.1060704|    2| 0.9483466|
|Inverse variance weighted | 0.6656189|    3| 0.8812593|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.2956204| 0.3951987| 0.5324402|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        5.52e-05|              0|TRUE                     |    0.4837967|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/ZSWIM7Dendritic_Cell_DC_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/ZSWIM7Dendritic_Cell_DC_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/ZSWIM7Dendritic_Cell_DC_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/ZSWIM7Dendritic_Cell_DC_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
