

# Two sample MR report

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## ETS2_Conventional Dendritic Cell against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3| -0.1288360| 0.4563569| 0.8248319|
|Weighted median           |    3|  0.0527827| 0.0219911| 0.0163867|
|Inverse variance weighted |    3|  0.0512133| 0.0177289| 0.0038685|
|Simple mode               |    3|  0.0560568| 0.0245174| 0.1495383|
|Weighted mode             |    3|  0.0559547| 0.0264344| 0.1685041|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0179196|    1| 0.8935101|
|Inverse variance weighted | 0.1738137|    2| 0.9167625|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|        0.077627| 0.1966064| 0.7606021|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        5.43e-05|              0|TRUE                     |    0.4855985|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/ETS2Conventional_Dendritic_Cell_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/ETS2Conventional_Dendritic_Cell_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/ETS2Conventional_Dendritic_Cell_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/ETS2Conventional_Dendritic_Cell_against_UKBb18436chunk8-1.png)
