

# Two sample MR report

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## RRP7A_Epithelial against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   16|  0.0771671| 0.1105873| 0.4967332|
|Weighted median           |   16| -0.0770389| 0.0181602| 0.0000221|
|Inverse variance weighted |   16| -0.0597255| 0.0173880| 0.0005928|
|Simple mode               |   16| -0.0905640| 0.0272459| 0.0046260|
|Weighted mode             |   16| -0.0815285| 0.0276220| 0.0099017|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 22.86869|   14| 0.0624402|
|Inverse variance weighted | 25.43277|   15| 0.0444248|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.1018342| 0.0812802| 0.2307729|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0002056|              0|TRUE                     |    0.1757197|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/RRP7AEpithelial_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/RRP7AEpithelial_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/RRP7AEpithelial_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/RRP7AEpithelial_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
