

# Two sample MR report

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## PRKAR1B_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    6| -0.0069648| 0.1682652| 0.9689673|
|Weighted median           |    6|  0.0566186| 0.0252964| 0.0252077|
|Inverse variance weighted |    6|  0.0542968| 0.0204807| 0.0080225|
|Simple mode               |    6|  0.0641039| 0.0320237| 0.1017101|
|Weighted mode             |    6|  0.0639035| 0.0342346| 0.1209348|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.4426647|    4| 0.9788372|
|Inverse variance weighted | 0.5772105|    5| 0.9890229|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0395795| 0.1079034| 0.7323447|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        7.81e-05|              0|TRUE                     |    0.4019563|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/PRKAR1BMacrophages_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/PRKAR1BMacrophages_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/PRKAR1BMacrophages_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/PRKAR1BMacrophages_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
