

# Two sample MR report

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## DIMT1_Epithelial against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3| -0.2022295| 0.2321124| 0.5437307|
|Weighted median           |    3|  0.0497255| 0.0286948| 0.0831111|
|Inverse variance weighted |    3|  0.0477353| 0.0241376| 0.0479698|
|Simple mode               |    3|  0.0740361| 0.0392165| 0.1996551|
|Weighted mode             |    3|  0.0695599| 0.0408261| 0.2305305|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.6967202|    1| 0.4038879|
|Inverse variance weighted | 1.8691402|    2| 0.3927547|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.1583409| 0.1462351| 0.4747099|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        3.08e-05|              0|TRUE                     |    0.5997185|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/DIMT1Epithelial_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/DIMT1Epithelial_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/DIMT1Epithelial_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/DIMT1Epithelial_against_bbja88chunk8-1.png)
