

# Two sample MR report

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## RIC3_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   14| -0.0280610| 0.0314994| 0.3905264|
|Weighted median           |   14| -0.0274395| 0.0080526| 0.0006555|
|Inverse variance weighted |   14| -0.0231230| 0.0059864| 0.0001122|
|Simple mode               |   14| -0.0286299| 0.0119220| 0.0319986|
|Weighted mode             |   14| -0.0277754| 0.0115971| 0.0323841|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 12.08309|   12| 0.4390300|
|Inverse variance weighted | 12.10877|   13| 0.5187458|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0045455| 0.0284635| 0.8757779|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0003033|              0|TRUE                     |    0.0986106|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/RIC3Epithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/RIC3Epithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/RIC3Epithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/RIC3Epithelial_against_UKBb18436chunk8-1.png)
