

# Two sample MR report

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## TSTD1_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    8|  0.0903183| 0.0528001| 0.1380105|
|Weighted median           |    8| -0.0053615| 0.0123375| 0.6638725|
|Inverse variance weighted |    8| -0.0205833| 0.0095321| 0.0308216|
|Simple mode               |    8| -0.0034950| 0.0220967| 0.8787917|
|Weighted mode             |    8| -0.0026700| 0.0187740| 0.8909147|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.7377074|    6| 0.9936409|
|Inverse variance weighted | 5.2980365|    7| 0.6236426|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0667542| 0.0312594| 0.0766258|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001416|              0|TRUE                     |    0.2596589|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/TSTD1Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/TSTD1Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/TSTD1Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/TSTD1Macrophages_against_UKBb18436chunk8-1.png)
