

# Two sample MR report

---

## GABPB1-AS1_Epithelial against UKB-b-18436

Date: **13 January, 2026**

---

### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    4|  0.0593457| 0.1287996| 0.6902204|
|Weighted median           |    4| -0.0340662| 0.0141623| 0.0161541|
|Inverse variance weighted |    4| -0.0298118| 0.0122658| 0.0150787|
|Simple mode               |    4| -0.0347365| 0.0180522| 0.1500145|
|Weighted mode             |    4| -0.0345911| 0.0185567| 0.1591852|

---

### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0087475|    2| 0.9956358|
|Inverse variance weighted | 0.4922996|    3| 0.9205799|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0442234| 0.0635961| 0.5587497|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001364|              0|TRUE                     |    0.2669975|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/GABPB1AS1Epithelial_against_UKBb18436chunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/GABPB1AS1Epithelial_against_UKBb18436chunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/GABPB1AS1Epithelial_against_UKBb18436chunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/GABPB1AS1Epithelial_against_UKBb18436chunk8-1.png)
