

# Two sample MR report

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## WASHC2A_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    5| -0.2762433| 0.1675675| 0.1977996|
|Weighted median           |    5| -0.0379597| 0.0164015| 0.0206458|
|Inverse variance weighted |    5| -0.0366943| 0.0130994| 0.0050908|
|Simple mode               |    5| -0.0587197| 0.0248169| 0.0771463|
|Weighted mode             |    5| -0.0126653| 0.0226828| 0.6063710|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.038319|    3| 0.7919809|
|Inverse variance weighted | 3.094548|    4| 0.5421295|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.1149971| 0.0801957| 0.2470489|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|           5e-05|              0|TRUE                     |    0.5044114|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/WASHC2AEpithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/WASHC2AEpithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/WASHC2AEpithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/WASHC2AEpithelial_against_UKBb18436chunk8-1.png)
