

# Two sample MR report

---

## DRAM2_Macrophages against UKB-b-18436

Date: **13 January, 2026**

---

### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3| -0.0617064| 0.7413689| 0.9471340|
|Weighted median           |    3|  0.0564447| 0.0200256| 0.0048228|
|Inverse variance weighted |    3|  0.0552807| 0.0162277| 0.0006578|
|Simple mode               |    3|  0.0572013| 0.0236265| 0.1365200|
|Weighted mode             |    3|  0.0572013| 0.0235924| 0.1362027|

---

### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0005720|    1| 0.9809192|
|Inverse variance weighted | 0.0254844|    2| 0.9873386|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0538072| 0.3409047| 0.9003402|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        2.49e-05|              0|TRUE                     |    0.6390772|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/DRAM2Macrophages_against_UKBb18436chunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/DRAM2Macrophages_against_UKBb18436chunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/DRAM2Macrophages_against_UKBb18436chunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/DRAM2Macrophages_against_UKBb18436chunk8-1.png)
