

# Two sample MR report

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## HLA-DQB1_Interstitial Macrophages against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    7| -0.0008680| 0.3011794| 0.9978120|
|Weighted median           |    7| -0.0577722| 0.0326352| 0.0766866|
|Inverse variance weighted |    7| -0.0591257| 0.0265284| 0.0258293|
|Simple mode               |    7| -0.0556670| 0.0435855| 0.2487300|
|Weighted mode             |    7| -0.0552369| 0.0443258| 0.2591550|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0050770|    5| 0.9999999|
|Inverse variance weighted | 0.0427854|    6| 0.9999984|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|      -0.0304032| 0.156567| 0.8536728|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0002222|              0|TRUE                     |     0.156061|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/HLADQB1Interstitial_Macrophages_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/HLADQB1Interstitial_Macrophages_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/HLADQB1Interstitial_Macrophages_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/HLADQB1Interstitial_Macrophages_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
