

# Two sample MR report

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## NQO2_Alveolar Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3| -0.0345507| 1.2975381| 0.9830521|
|Weighted median           |    3|  0.0387800| 0.0141531| 0.0061433|
|Inverse variance weighted |    3|  0.0388205| 0.0110683| 0.0004526|
|Simple mode               |    3|  0.0386896| 0.0156083| 0.1314202|
|Weighted mode             |    3|  0.0386608| 0.0158988| 0.1355614|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0000866|    1| 0.9925737|
|Inverse variance weighted | 0.0032844|    2| 0.9983592|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0519412| 0.9185233| 0.9640384|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        3.02e-05|              0|TRUE                     |      0.60567|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/NQO2Alveolar_Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/NQO2Alveolar_Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/NQO2Alveolar_Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/NQO2Alveolar_Macrophages_against_UKBb18436chunk8-1.png)
