

# Two sample MR report

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## C10orf11_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    8| 0.3676272| 0.2629856| 0.2116402|
|Weighted median           |    8| 0.0502605| 0.0297747| 0.0914063|
|Inverse variance weighted |    8| 0.0723111| 0.0230861| 0.0017348|
|Simple mode               |    8| 0.0448602| 0.0426848| 0.3281975|
|Weighted mode             |    8| 0.0448602| 0.0394987| 0.2934508|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 2.325850|    6| 0.8874261|
|Inverse variance weighted | 3.596629|    7| 0.8248872|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|     pval|
|---------------:|---------:|--------:|
|      -0.1563691| 0.1387126| 0.302674|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001396|              0|TRUE                     |    0.2633507|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/C10orf11Macrophages_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/C10orf11Macrophages_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/C10orf11Macrophages_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/C10orf11Macrophages_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
