

# Two sample MR report

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## ANXA5_Conventional Dendritic Cell against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    5| -0.0092037| 0.0980356| 0.9311225|
|Weighted median           |    5|  0.0353678| 0.0148761| 0.0174306|
|Inverse variance weighted |    5|  0.0371345| 0.0121198| 0.0021844|
|Simple mode               |    5|  0.0317025| 0.0194426| 0.1783159|
|Weighted mode             |    5|  0.0326465| 0.0185154| 0.1526440|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.8186887|    3| 0.8449919|
|Inverse variance weighted | 1.0455695|    4| 0.9028092|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0221037| 0.0464052| 0.6663873|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001725|              0|TRUE                     |    0.2132437|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/ANXA5Conventional_Dendritic_Cell_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/ANXA5Conventional_Dendritic_Cell_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/ANXA5Conventional_Dendritic_Cell_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/ANXA5Conventional_Dendritic_Cell_against_UKBb18436chunk8-1.png)
