

# Two sample MR report

---

## TAGLN_Monocyte (Mono) against UKB-b-18436

Date: **13 January, 2026**

---

### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    6|  0.0667755| 0.2953986| 0.8322419|
|Weighted median           |    6| -0.0684724| 0.0153018| 0.0000076|
|Inverse variance weighted |    6| -0.0721601| 0.0116875| 0.0000000|
|Simple mode               |    6| -0.0676479| 0.0209293| 0.0231491|
|Weighted mode             |    6| -0.0675833| 0.0219888| 0.0276723|

---

### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.1480430|    4| 0.9973919|
|Inverse variance weighted | 0.3696025|    5| 0.9961257|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.1597895| 0.3394712| 0.6623746|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        3.74e-05|              0|TRUE                     |    0.5698947|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/TAGLNMonocyte_Mono_against_UKBb18436chunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/TAGLNMonocyte_Mono_against_UKBb18436chunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/TAGLNMonocyte_Mono_against_UKBb18436chunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/TAGLNMonocyte_Mono_against_UKBb18436chunk8-1.png)
