

# Two sample MR report

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## PLD1_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    6| -0.0420583| 0.1592720| 0.8047760|
|Weighted median           |    6| -0.0399783| 0.0113447| 0.0004252|
|Inverse variance weighted |    6| -0.0388800| 0.0097572| 0.0000675|
|Simple mode               |    6| -0.0430125| 0.0153362| 0.0377866|
|Weighted mode             |    6| -0.0427417| 0.0155849| 0.0406706|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.2956524|    4| 0.9900931|
|Inverse variance weighted | 0.2960521|    5| 0.9977167|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0021831| 0.1091939| 0.9850067|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        5.55e-05|              0|TRUE                     |     0.482073|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/PLD1Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/PLD1Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/PLD1Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/PLD1Macrophages_against_UKBb18436chunk8-1.png)
