

# Two sample MR report

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## WBSCR27_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    3| 0.3711147| 0.6015906| 0.6481112|
|Weighted median           |    3| 0.0841056| 0.0307118| 0.0061712|
|Inverse variance weighted |    3| 0.0755374| 0.0246232| 0.0021568|
|Simple mode               |    3| 0.0851504| 0.0340524| 0.1295635|
|Weighted mode             |    3| 0.0851504| 0.0371407| 0.1488982|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0851026|    1| 0.7704981|
|Inverse variance weighted | 0.3269092|    2| 0.8492050|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.2306296| 0.4690086| 0.7090542|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|         2.5e-05|              0|TRUE                     |    0.6380078|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/WBSCR27Macrophages_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/WBSCR27Macrophages_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/WBSCR27Macrophages_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/WBSCR27Macrophages_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
