

# Two sample MR report

---

## SHTN1_Monocyte (Mono) against UKB-b-18436

Date: **13 January, 2026**

---

### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    9| 0.1457727| 0.1301240| 0.2995618|
|Weighted median           |    9| 0.0611853| 0.0121835| 0.0000005|
|Inverse variance weighted |    9| 0.0515871| 0.0153532| 0.0007793|
|Simple mode               |    9| 0.0713343| 0.0145689| 0.0011993|
|Weighted mode             |    9| 0.0645884| 0.0149108| 0.0025064|

---

### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 22.86590|    7| 0.0017987|
|Inverse variance weighted | 24.60296|    8| 0.0018145|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0520261| 0.0713443| 0.4895387|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0002376|          1e-07|TRUE                     |    0.1489236|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/SHTN1Monocyte_Mono_against_UKBb18436chunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/SHTN1Monocyte_Mono_against_UKBb18436chunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/SHTN1Monocyte_Mono_against_UKBb18436chunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/SHTN1Monocyte_Mono_against_UKBb18436chunk8-1.png)
