

# Two sample MR report

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## PARK7_Monocyte (Mono) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    6|  0.3815713| 0.9395299| 0.7054353|
|Weighted median           |    6| -0.0463188| 0.0196402| 0.0183554|
|Inverse variance weighted |    6| -0.0507638| 0.0162068| 0.0017347|
|Simple mode               |    6| -0.0405938| 0.0311777| 0.2496631|
|Weighted mode             |    6| -0.0402701| 0.0261597| 0.1843297|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.3765822|    4| 0.9843489|
|Inverse variance weighted | 0.5883935|    5| 0.9885285|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.1327757| 0.2884988| 0.6692579|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        5.27e-05|              0|TRUE                     |    0.4921399|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/PARK7Monocyte_Mono_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/PARK7Monocyte_Mono_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/PARK7Monocyte_Mono_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/PARK7Monocyte_Mono_against_UKBb18436chunk8-1.png)
