

# Two sample MR report

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## IDH2_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    5| -0.1250783| 0.1574582| 0.4850228|
|Weighted median           |    5|  0.0406606| 0.0155670| 0.0090020|
|Inverse variance weighted |    5|  0.0339191| 0.0124785| 0.0065638|
|Simple mode               |    5|  0.0413395| 0.0202981| 0.1113711|
|Weighted mode             |    5|  0.0413395| 0.0207094| 0.1166253|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.1661623|    3| 0.9828576|
|Inverse variance weighted | 1.1922520|    4| 0.8793726|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0706906| 0.0697861| 0.3856776|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001051|              0|TRUE                     |    0.3306093|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/IDH2Epithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/IDH2Epithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/IDH2Epithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/IDH2Epithelial_against_UKBb18436chunk8-1.png)
