

# Two sample MR report

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## BCL6_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    6|  0.1231813| 0.1362900| 0.4172028|
|Weighted median           |    6| -0.0614613| 0.0220845| 0.0053858|
|Inverse variance weighted |    6| -0.0692082| 0.0170581| 0.0000497|
|Simple mode               |    6| -0.0620126| 0.0307449| 0.0997510|
|Weighted mode             |    6| -0.0613809| 0.0302377| 0.0981177|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.1891033|    4| 0.9958020|
|Inverse variance weighted | 2.2134845|    5| 0.8188858|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0735545| 0.0516967| 0.2278725|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        5.07e-05|              0|TRUE                     |    0.5036324|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/BCL6Epithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/BCL6Epithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/BCL6Epithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/BCL6Epithelial_against_UKBb18436chunk8-1.png)
