

# Two sample MR report

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## FXYD5_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   11| -0.2085363| 0.2396614| 0.4068384|
|Weighted median           |   11| -0.1372829| 0.0387643| 0.0003979|
|Inverse variance weighted |   11| -0.1049562| 0.0290003| 0.0002956|
|Simple mode               |   11| -0.1435968| 0.0561937| 0.0285984|
|Weighted mode             |   11| -0.1429466| 0.0589417| 0.0357413|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 6.206906|    9| 0.7190450|
|Inverse variance weighted | 6.396473|   10| 0.7809265|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0368801| 0.0847052| 0.6735319|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001435|              0|TRUE                     |     0.256556|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/FXYD5Macrophages_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/FXYD5Macrophages_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/FXYD5Macrophages_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/FXYD5Macrophages_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
