

# Two sample MR report

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## SPATA20_T Proliferating against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    4| -0.0221142| 0.1582231| 0.9016497|
|Weighted median           |    4|  0.0221888| 0.0108442| 0.0407415|
|Inverse variance weighted |    4|  0.0219598| 0.0094042| 0.0195371|
|Simple mode               |    4|  0.0228579| 0.0145000| 0.2130224|
|Weighted mode             |    4|  0.0225036| 0.0143771| 0.2154942|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0700940|    2| 0.9655600|
|Inverse variance weighted | 0.1479627|    3| 0.9855172|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0287385| 0.1029872| 0.8064147|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        4.02e-05|              0|TRUE                     |    0.5473638|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/SPATA20T_Proliferating_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/SPATA20T_Proliferating_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/SPATA20T_Proliferating_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/SPATA20T_Proliferating_against_UKBb18436chunk8-1.png)
