

# Two sample MR report

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## DMAP1_Alveolar Macrophages against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3| -0.2672608| 1.0936082| 0.8474108|
|Weighted median           |    3|  0.0993193| 0.0287286| 0.0005459|
|Inverse variance weighted |    3|  0.0964181| 0.0218439| 0.0000101|
|Simple mode               |    3|  0.1016745| 0.0322874| 0.0877688|
|Weighted mode             |    3|  0.1016008| 0.0335076| 0.0937252|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0051639|    1| 0.9427133|
|Inverse variance weighted | 0.1157972|    2| 0.9437456|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.1811845| 0.5447259| 0.7955784|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        1.81e-05|              0|TRUE                     |    0.6930466|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/DMAP1Alveolar_Macrophages_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/DMAP1Alveolar_Macrophages_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/DMAP1Alveolar_Macrophages_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/DMAP1Alveolar_Macrophages_against_bbja88chunk8-1.png)
