

# Two sample MR report

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## C2orf74_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   20| -0.0516233| 0.0501560| 0.3169928|
|Weighted median           |   20| -0.0235366| 0.0062204| 0.0001545|
|Inverse variance weighted |   20| -0.0142561| 0.0068984| 0.0387741|
|Simple mode               |   20| -0.0351706| 0.0091667| 0.0011124|
|Weighted mode             |   20| -0.0313830| 0.0080265| 0.0009412|

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### Heterogeneity tests


|method                    |        Q| Q_df|   Q_pval|
|:-------------------------|--------:|----:|--------:|
|MR Egger                  | 51.32253|   18| 4.75e-05|
|Inverse variance weighted | 52.93637|   19| 4.79e-05|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0258249| 0.0343263| 0.4615743|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0005634|              0|TRUE                     |    0.0248169|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/C2orf74Epithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/C2orf74Epithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/C2orf74Epithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/C2orf74Epithelial_against_UKBb18436chunk8-1.png)
