

# Two sample MR report

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## CHD1L_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   18|  0.0731246| 0.0840540| 0.3971799|
|Weighted median           |   18| -0.0191862| 0.0078728| 0.0148081|
|Inverse variance weighted |   18| -0.0144179| 0.0057887| 0.0127484|
|Simple mode               |   18| -0.0252651| 0.0139480| 0.0877884|
|Weighted mode             |   18| -0.0252651| 0.0137668| 0.0840323|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 6.970157|   16| 0.9738320|
|Inverse variance weighted | 8.060058|   17| 0.9652456|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0464233| 0.0444675| 0.3120109|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0003179|              0|TRUE                     |    0.0900162|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/CHD1LMacrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/CHD1LMacrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/CHD1LMacrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/CHD1LMacrophages_against_UKBb18436chunk8-1.png)
