

# Two sample MR report

---

## ELP5_T Proliferating against UKB-b-18436

Date: **13 January, 2026**

---

### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    7|  0.0046832| 0.0754792| 0.9529298|
|Weighted median           |    7| -0.0244632| 0.0085509| 0.0042245|
|Inverse variance weighted |    7| -0.0257443| 0.0068282| 0.0001631|
|Simple mode               |    7| -0.0243702| 0.0122223| 0.0932092|
|Weighted mode             |    7| -0.0242682| 0.0115936| 0.0812332|

---

### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.1712782|    5| 0.9993924|
|Inverse variance weighted | 0.3351283|    6| 0.9993081|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|      -0.0205679| 0.050812| 0.7023722|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001788|              0|TRUE                     |    0.2056919|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/ELP5T_Proliferating_against_UKBb18436chunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/ELP5T_Proliferating_against_UKBb18436chunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/ELP5T_Proliferating_against_UKBb18436chunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/ELP5T_Proliferating_against_UKBb18436chunk8-1.png)
