

# Two sample MR report

---

## ANXA5_Monocyte (Mono) against UKB-b-18436

Date: **13 January, 2026**

---

### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    6| 0.0385136| 0.0739314| 0.6299191|
|Weighted median           |    6| 0.0312948| 0.0116472| 0.0072120|
|Inverse variance weighted |    6| 0.0323963| 0.0097538| 0.0008956|
|Simple mode               |    6| 0.0300645| 0.0156710| 0.1131501|
|Weighted mode             |    6| 0.0306973| 0.0154145| 0.1030578|

---

### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.6696230|    4| 0.9550215|
|Inverse variance weighted | 0.6765908|    5| 0.9842287|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0032658| 0.0391235| 0.9374857|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001583|              0|TRUE                     |    0.2333613|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/ANXA5Monocyte_Mono_against_UKBb18436chunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/ANXA5Monocyte_Mono_against_UKBb18436chunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/ANXA5Monocyte_Mono_against_UKBb18436chunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/ANXA5Monocyte_Mono_against_UKBb18436chunk8-1.png)
