

# Two sample MR report

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## IRF5_Alveolar Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    4| -0.0763681| 0.3310748| 0.8390209|
|Weighted median           |    4|  0.0371818| 0.0155060| 0.0164895|
|Inverse variance weighted |    4|  0.0376253| 0.0132444| 0.0044993|
|Simple mode               |    4|  0.0429685| 0.0200854| 0.1219352|
|Weighted mode             |    4|  0.0327846| 0.0182234| 0.1698430|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0872279|    2| 0.9573234|
|Inverse variance weighted | 0.2059696|    3| 0.9766199|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|     pval|
|---------------:|---------:|--------:|
|       0.0525179| 0.1524074| 0.763265|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        3.16e-05|              0|TRUE                     |    0.5951262|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/IRF5Alveolar_Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/IRF5Alveolar_Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/IRF5Alveolar_Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/IRF5Alveolar_Macrophages_against_UKBb18436chunk8-1.png)
