

# Two sample MR report

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## RPS26_Dendritic Cell (DC) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   11| -0.0647947| 0.0483026| 0.2126445|
|Weighted median           |   11| -0.0440734| 0.0088965| 0.0000007|
|Inverse variance weighted |   11| -0.0488883| 0.0066147| 0.0000000|
|Simple mode               |   11| -0.0387449| 0.0121615| 0.0097219|
|Weighted mode             |   11| -0.0417231| 0.0113657| 0.0043103|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 9.232093|    9| 0.4161318|
|Inverse variance weighted | 9.345514|   10| 0.4996568|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0096704| 0.0290822| 0.7471103|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0013063|          1e-07|TRUE                     |    0.0006272|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/RPS26Dendritic_Cell_DC_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/RPS26Dendritic_Cell_DC_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/RPS26Dendritic_Cell_DC_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/RPS26Dendritic_Cell_DC_against_UKBb18436chunk8-1.png)
