

# Two sample MR report

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## TNFSF10_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    5| -0.0116652| 0.0553435| 0.8465655|
|Weighted median           |    5| -0.0505093| 0.0108759| 0.0000034|
|Inverse variance weighted |    5| -0.0498043| 0.0081646| 0.0000000|
|Simple mode               |    5| -0.0532965| 0.0140709| 0.0193071|
|Weighted mode             |    5| -0.0521659| 0.0135150| 0.0181494|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0558562|    3| 0.9965473|
|Inverse variance weighted | 0.5413277|    4| 0.9693550|

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### Test for directional horizontal pleiotropy


| egger_intercept|      se|      pval|
|---------------:|-------:|---------:|
|      -0.0300233| 0.04309| 0.5360904|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001166|              0|TRUE                     |    0.3120219|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/TNFSF10Epithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/TNFSF10Epithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/TNFSF10Epithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/TNFSF10Epithelial_against_UKBb18436chunk8-1.png)
