

# Two sample MR report

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## TPM1_Endothelial Cell (Endo) against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    4|  0.0388819| 2.2139622| 0.9875827|
|Weighted median           |    4| -0.0983792| 0.0507640| 0.0526266|
|Inverse variance weighted |    4| -0.0988773| 0.0447888| 0.0272696|
|Simple mode               |    4| -0.0977621| 0.0677945| 0.2449673|
|Weighted mode             |    4| -0.0979203| 0.0686137| 0.2488234|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0129457|    2| 0.9935480|
|Inverse variance weighted | 0.0168190|    3| 0.9994228|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0554316| 0.8906734| 0.9560353|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        6.45e-05|              0|TRUE                     |    0.4453272|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/TPM1Endothelial_Cell_Endo_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/TPM1Endothelial_Cell_Endo_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/TPM1Endothelial_Cell_Endo_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/TPM1Endothelial_Cell_Endo_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
