

# Two sample MR report

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## JAML_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    8| -0.0292801| 0.1203319| 0.8158569|
|Weighted median           |    8| -0.0339719| 0.0164114| 0.0384514|
|Inverse variance weighted |    8| -0.0273497| 0.0134133| 0.0414505|
|Simple mode               |    8| -0.0383452| 0.0239517| 0.1534248|
|Weighted mode             |    8| -0.0385377| 0.0245656| 0.1606908|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 2.051195|    6| 0.9149305|
|Inverse variance weighted | 2.051455|    7| 0.9569376|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0007691| 0.0476453| 0.9876438|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|         0.00011|              0|TRUE                     |    0.3185879|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/JAMLMacrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/JAMLMacrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/JAMLMacrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/JAMLMacrophages_against_UKBb18436chunk8-1.png)
