

# Two sample MR report

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## HLA-DQA1_Monocyte (Mono) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   30| -0.1818508| 0.1153037| 0.1259946|
|Weighted median           |   30|  0.1549526| 0.0159115| 0.0000000|
|Inverse variance weighted |   30|  0.1325029| 0.0197283| 0.0000000|
|Simple mode               |   30|  0.2003204| 0.0246274| 0.0000000|
|Weighted mode             |   30|  0.1921152| 0.0403492| 0.0000492|

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### Heterogeneity tests


|method                    |        Q| Q_df| Q_pval|
|:-------------------------|--------:|----:|------:|
|MR Egger                  | 126.9344|   28|      0|
|Inverse variance weighted | 161.4527|   29|      0|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|     pval|
|---------------:|---------:|--------:|
|       0.0949856| 0.0344226| 0.010093|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0002872|          8e-07|TRUE                     |     0.126356|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/HLADQA1Monocyte_Mono_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/HLADQA1Monocyte_Mono_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/HLADQA1Monocyte_Mono_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/HLADQA1Monocyte_Mono_against_UKBb18436chunk8-1.png)
