

# Two sample MR report

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## HLA-DRB5_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |  100| -0.0969021| 0.0153229| 0.0000000|
|Weighted median           |  100|  0.0175594| 0.0046708| 0.0001703|
|Inverse variance weighted |  100|  0.0204086| 0.0042069| 0.0000012|
|Simple mode               |  100|  0.0355124| 0.0175354| 0.0455408|
|Weighted mode             |  100| -0.0170846| 0.0132404| 0.1999383|

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### Heterogeneity tests


|method                    |        Q| Q_df|   Q_pval|
|:-------------------------|--------:|----:|--------:|
|MR Egger                  | 162.9951|   98| 4.14e-05|
|Inverse variance weighted | 265.2656|   99| 0.00e+00|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se| pval|
|---------------:|---------:|----:|
|       0.0649314| 0.0082805|    0|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0017277|          3e-07|TRUE                     |     9.28e-05|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/HLADRB5Epithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/HLADRB5Epithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/HLADRB5Epithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/HLADRB5Epithelial_against_UKBb18436chunk8-1.png)
