

# Two sample MR report

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## PLGRKT_Dendritic Cell (DC) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    6| -0.0752961| 0.0688857| 0.3357826|
|Weighted median           |    6| -0.0411068| 0.0109628| 0.0001771|
|Inverse variance weighted |    6| -0.0399170| 0.0086711| 0.0000042|
|Simple mode               |    6| -0.0430577| 0.0141352| 0.0285501|
|Weighted mode             |    6| -0.0432520| 0.0149775| 0.0342743|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.3537111|    4| 0.9860882|
|Inverse variance weighted | 0.6217334|    5| 0.9869866|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0204786| 0.0395563| 0.6319761|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001325|              0|TRUE                     |    0.2774638|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/PLGRKTDendritic_Cell_DC_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/PLGRKTDendritic_Cell_DC_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/PLGRKTDendritic_Cell_DC_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/PLGRKTDendritic_Cell_DC_against_UKBb18436chunk8-1.png)
