

# Two sample MR report

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## NDUFS5_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    3| 0.3318699| 0.3671929| 0.5321405|
|Weighted median           |    3| 0.1364310| 0.0548654| 0.0128953|
|Inverse variance weighted |    3| 0.1304367| 0.0457324| 0.0043421|
|Simple mode               |    3| 0.1477982| 0.0668910| 0.1577474|
|Weighted mode             |    3| 0.1450724| 0.0692390| 0.1711379|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0379951|    1| 0.8454529|
|Inverse variance weighted | 0.3436722|    2| 0.8421172|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0924182| 0.1671577| 0.6784738|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        6.73e-05|              0|TRUE                     |    0.4374115|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/NDUFS5Macrophages_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/NDUFS5Macrophages_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/NDUFS5Macrophages_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/NDUFS5Macrophages_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
