

# Two sample MR report

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## TOMM7_Monocyte (Mono) against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    7| 0.1643851| 0.3113125| 0.6200590|
|Weighted median           |    7| 0.1181417| 0.0508411| 0.0201393|
|Inverse variance weighted |    7| 0.1144567| 0.0418215| 0.0062042|
|Simple mode               |    7| 0.1232560| 0.0706495| 0.1316678|
|Weighted mode             |    7| 0.1201124| 0.0716141| 0.1445122|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.4913113|    5| 0.9924380|
|Inverse variance weighted | 0.5175058|    6| 0.9976189|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0150016| 0.0926901| 0.8777631|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        9.02e-05|              0|TRUE                     |    0.3678672|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/TOMM7Monocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/TOMM7Monocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/TOMM7Monocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/TOMM7Monocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
