

# Two sample MR report

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## PLOD2_Epithelial against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    9| -0.2282608| 0.2072915| 0.3072452|
|Weighted median           |    9| -0.0277253| 0.0174528| 0.1121548|
|Inverse variance weighted |    9| -0.0495894| 0.0136803| 0.0002891|
|Simple mode               |    9| -0.0890585| 0.0348292| 0.0338040|
|Weighted mode             |    9| -0.0131934| 0.0242631| 0.6014249|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 10.89586|    7| 0.1432267|
|Inverse variance weighted | 12.05749|    8| 0.1486573|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|       0.0966498| 0.111879| 0.4162715|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0002026|              0|TRUE                     |    0.1795716|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/PLOD2Epithelial_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/PLOD2Epithelial_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/PLOD2Epithelial_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/PLOD2Epithelial_against_bbja88chunk8-1.png)
