

# Two sample MR report

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## CD52_Alveolar Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    5| 0.0489018| 0.2183104| 0.8371443|
|Weighted median           |    5| 0.0607018| 0.0161034| 0.0001636|
|Inverse variance weighted |    5| 0.0623990| 0.0126297| 0.0000008|
|Simple mode               |    5| 0.0585669| 0.0222641| 0.0581526|
|Weighted mode             |    5| 0.0588038| 0.0205032| 0.0455588|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.5317048|    3| 0.9118728|
|Inverse variance weighted | 0.5355400|    4| 0.9699502|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0064034| 0.1033982| 0.9545142|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        3.49e-05|              0|TRUE                     |    0.5809255|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/CD52Alveolar_Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/CD52Alveolar_Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/CD52Alveolar_Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/CD52Alveolar_Macrophages_against_UKBb18436chunk8-1.png)
