

# Two sample MR report

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## RPS16_Monocyte (Mono) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    6| 0.1102588| 0.1646500| 0.5397490|
|Weighted median           |    6| 0.0987635| 0.0235808| 0.0000281|
|Inverse variance weighted |    6| 0.1019493| 0.0189538| 0.0000001|
|Simple mode               |    6| 0.0921133| 0.0335958| 0.0407042|
|Weighted mode             |    6| 0.0932652| 0.0312710| 0.0307119|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.7854342|    4| 0.9403901|
|Inverse variance weighted | 0.7880155|    5| 0.9777914|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0023305| 0.0458706| 0.9619162|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0002535|              0|TRUE                     |    0.1330822|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/RPS16Monocyte_Mono_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/RPS16Monocyte_Mono_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/RPS16Monocyte_Mono_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/RPS16Monocyte_Mono_against_UKBb18436chunk8-1.png)
