

# Two sample MR report

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## GBP3_Alveolar Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   18|  0.0141531| 0.0287324| 0.6289987|
|Weighted median           |   18| -0.0105495| 0.0048464| 0.0294970|
|Inverse variance weighted |   18| -0.0100437| 0.0036471| 0.0058890|
|Simple mode               |   18| -0.0149000| 0.0076346| 0.0676555|
|Weighted mode             |   18| -0.0118821| 0.0079370| 0.1527148|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  |  9.342314|   16| 0.8986496|
|Inverse variance weighted | 10.063130|   17| 0.9009420|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0196828| 0.0231832| 0.4083999|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0004943|              0|TRUE                     |    0.0344669|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/GBP3Alveolar_Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/GBP3Alveolar_Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/GBP3Alveolar_Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/GBP3Alveolar_Macrophages_against_UKBb18436chunk8-1.png)
