

# Two sample MR report

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## ELP5_Conventional Dendritic Cell against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    8|  0.0058794| 0.1673109| 0.9731074|
|Weighted median           |    8| -0.0251651| 0.0077343| 0.0011390|
|Inverse variance weighted |    8| -0.0256153| 0.0063748| 0.0000586|
|Simple mode               |    8| -0.0249150| 0.0112211| 0.0618424|
|Weighted mode             |    8| -0.0248484| 0.0098518| 0.0396818|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.1752488|    6| 0.9998950|
|Inverse variance weighted | 0.2107349|    7| 0.9999699|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0213499| 0.1133356| 0.8567906|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001255|              0|TRUE                     |    0.2898489|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/ELP5Conventional_Dendritic_Cell_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/ELP5Conventional_Dendritic_Cell_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/ELP5Conventional_Dendritic_Cell_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/ELP5Conventional_Dendritic_Cell_against_UKBb18436chunk8-1.png)
