

# Two sample MR report

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## ERAP2_Monocyte (Mono) against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    9| -0.0083505| 0.2250189| 0.9714331|
|Weighted median           |    9| -0.0583235| 0.0194244| 0.0026769|
|Inverse variance weighted |    9| -0.0572475| 0.0156069| 0.0002444|
|Simple mode               |    9| -0.0589028| 0.0279548| 0.0681832|
|Weighted mode             |    9| -0.0587022| 0.0286435| 0.0745770|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.8541061|    7| 0.9968518|
|Inverse variance weighted | 0.9015544|    8| 0.9987971|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|     pval|
|---------------:|--------:|--------:|
|       -0.032999| 0.151492| 0.833778|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0003282|              0|TRUE                     |    0.0852522|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/ERAP2Monocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/ERAP2Monocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/ERAP2Monocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/ERAP2Monocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
