

# Two sample MR report

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## SRSF2_Monocyte (Mono) against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    5| -0.6524501| 0.8973367| 0.5197692|
|Weighted median           |    5| -0.1630710| 0.0581261| 0.0050243|
|Inverse variance weighted |    5| -0.1900356| 0.0507589| 0.0001812|
|Simple mode               |    5| -0.2592266| 0.0980813| 0.0574014|
|Weighted mode             |    5| -0.0956330| 0.0933081| 0.3633364|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 6.211768|    3| 0.1017497|
|Inverse variance weighted | 6.763784|    4| 0.1489103|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.1673046| 0.3240257| 0.6412703|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        8.45e-05|              0|TRUE                     |    0.3919277|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/SRSF2Monocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/SRSF2Monocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/SRSF2Monocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/SRSF2Monocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
