

# Two sample MR report

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## PKIB_Monocyte (Mono) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   10| -0.1287703| 0.0671253| 0.0913465|
|Weighted median           |   10|  0.0166188| 0.0080211| 0.0382750|
|Inverse variance weighted |   10|  0.0163613| 0.0060754| 0.0070803|
|Simple mode               |   10|  0.0182546| 0.0135359| 0.2104163|
|Weighted mode             |   10|  0.0127657| 0.0127000| 0.3410704|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.6054751|    8| 0.9997249|
|Inverse variance weighted | 5.3187698|    9| 0.8056822|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.1041633| 0.0479791| 0.0617211|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        0.000158|              0|TRUE                     |    0.2333072|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/PKIBMonocyte_Mono_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/PKIBMonocyte_Mono_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/PKIBMonocyte_Mono_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/PKIBMonocyte_Mono_against_UKBb18436chunk8-1.png)
