

# Two sample MR report

---

## TUBGCP2_Epithelial against bbj-a-88

Date: **13 January, 2026**

---

### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    6| 0.1575761| 0.1530720| 0.3614534|
|Weighted median           |    6| 0.0531846| 0.0222148| 0.0166611|
|Inverse variance weighted |    6| 0.0409507| 0.0167281| 0.0143645|
|Simple mode               |    6| 0.0584561| 0.0301377| 0.1101224|
|Weighted mode             |    6| 0.0599389| 0.0294218| 0.0972120|

---

### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 4.147249|    4| 0.3864445|
|Inverse variance weighted | 4.756653|    5| 0.4462945|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0785696| 0.1024829| 0.4860286|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        6.34e-05|              0|TRUE                     |    0.4509993|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/TUBGCP2Epithelial_against_bbja88chunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/TUBGCP2Epithelial_against_bbja88chunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/TUBGCP2Epithelial_against_bbja88chunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/TUBGCP2Epithelial_against_bbja88chunk8-1.png)
