

# Two sample MR report

---

## MKNK1_Macrophages against UKB-b-18436

Date: **13 January, 2026**

---

### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    8| 0.0566209| 0.0920967| 0.5612642|
|Weighted median           |    8| 0.0152092| 0.0084081| 0.0704697|
|Inverse variance weighted |    8| 0.0170149| 0.0070004| 0.0150754|
|Simple mode               |    8| 0.0145469| 0.0122707| 0.2744979|
|Weighted mode             |    8| 0.0141830| 0.0124138| 0.2908060|

---

### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.013726|    6| 0.9850866|
|Inverse variance weighted | 1.199741|    7| 0.9909329|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0280667| 0.0650755| 0.6813194|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0002167|              0|TRUE                     |    0.1615232|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/MKNK1Macrophages_against_UKBb18436chunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/MKNK1Macrophages_against_UKBb18436chunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/MKNK1Macrophages_against_UKBb18436chunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/MKNK1Macrophages_against_UKBb18436chunk8-1.png)
