

# Two sample MR report

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## FLOT1_Alveolar Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    8| 0.0592939| 0.0579015| 0.3453149|
|Weighted median           |    8| 0.0204313| 0.0107578| 0.0575375|
|Inverse variance weighted |    8| 0.0224649| 0.0080257| 0.0051243|
|Simple mode               |    8| 0.0203892| 0.0170448| 0.2705546|
|Weighted mode             |    8| 0.0193702| 0.0162451| 0.2719639|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 3.310005|    6| 0.7690517|
|Inverse variance weighted | 3.722505|    7| 0.8111269|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0241464| 0.0375959| 0.5444467|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001714|              0|TRUE                     |    0.2141371|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/FLOT1Alveolar_Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/FLOT1Alveolar_Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/FLOT1Alveolar_Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/FLOT1Alveolar_Macrophages_against_UKBb18436chunk8-1.png)
