

# Two sample MR report

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## HP_Alveolar Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   12| -0.0398012| 0.0380117| 0.3197132|
|Weighted median           |   12|  0.0190579| 0.0066265| 0.0040274|
|Inverse variance weighted |   12|  0.0177555| 0.0054042| 0.0010179|
|Simple mode               |   12|  0.0303927| 0.0130340| 0.0397429|
|Weighted mode             |   12|  0.0246757| 0.0114753| 0.0546153|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 12.37395|   10| 0.2608084|
|Inverse variance weighted | 15.26306|   11| 0.1707679|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0468216| 0.0306421| 0.1575002|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0004095|              0|TRUE                     |    0.0557644|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/HPAlveolar_Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/HPAlveolar_Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/HPAlveolar_Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/HPAlveolar_Macrophages_against_UKBb18436chunk8-1.png)
