

# Two sample MR report

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## TOB1_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    8| -0.1390818| 0.1941676| 0.5007237|
|Weighted median           |    8|  0.0316038| 0.0131415| 0.0161776|
|Inverse variance weighted |    8|  0.0341178| 0.0104551| 0.0011013|
|Simple mode               |    8|  0.0325195| 0.0182947| 0.1187215|
|Weighted mode             |    8|  0.0314728| 0.0183098| 0.1293232|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.5752685|    6| 0.9967984|
|Inverse variance weighted | 1.3732650|    7| 0.9863761|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0758017| 0.0848551| 0.4060946|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        7.82e-05|              0|TRUE                     |    0.4020373|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/TOB1Epithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/TOB1Epithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/TOB1Epithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/TOB1Epithelial_against_UKBb18436chunk8-1.png)
