

# Two sample MR report

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## KANSL1-AS1_Alveolar Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   67| 0.0233279| 0.0128976| 0.0751218|
|Weighted median           |   67| 0.0196458| 0.0024653| 0.0000000|
|Inverse variance weighted |   67| 0.0176881| 0.0019045| 0.0000000|
|Simple mode               |   67| 0.0201639| 0.0052916| 0.0003070|
|Weighted mode             |   67| 0.0200378| 0.0052308| 0.0002872|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 25.16083|   65| 0.9999980|
|Inverse variance weighted | 25.35630|   66| 0.9999986|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0052346| 0.0118398| 0.6598682|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0027088|              0|TRUE                     |        7e-07|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/KANSL1AS1Alveolar_Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/KANSL1AS1Alveolar_Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/KANSL1AS1Alveolar_Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/KANSL1AS1Alveolar_Macrophages_against_UKBb18436chunk8-1.png)
