

# Two sample MR report

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## CYGB_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    8| 0.0210738| 0.0369117| 0.5887791|
|Weighted median           |    8| 0.0113088| 0.0070152| 0.1069527|
|Inverse variance weighted |    8| 0.0132850| 0.0057703| 0.0213184|
|Simple mode               |    8| 0.0104566| 0.0102716| 0.3425601|
|Weighted mode             |    8| 0.0105720| 0.0096408| 0.3091045|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.6162280|    6| 0.9961238|
|Inverse variance weighted | 0.6618696|    7| 0.9986119|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0073834| 0.0345603| 0.8379033|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0002175|              0|TRUE                     |    0.1605953|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/CYGBEpithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/CYGBEpithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/CYGBEpithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/CYGBEpithelial_against_UKBb18436chunk8-1.png)
