

# Two sample MR report

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## HLA-DRB5_Alveolar Macrophages against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    4| -0.2319622| 0.2504650| 0.4521505|
|Weighted median           |    4| -0.1109893| 0.0309251| 0.0003320|
|Inverse variance weighted |    4| -0.1099325| 0.0258452| 0.0000210|
|Simple mode               |    4| -0.0909566| 0.0426108| 0.1224777|
|Weighted mode             |    4| -0.1267072| 0.0442075| 0.0642500|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.3755772|    2| 0.8287899|
|Inverse variance weighted | 0.6155083|    3| 0.8928731|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0416058| 0.0849396| 0.6727151|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|         5.5e-05|          2e-07|TRUE                     |    0.5059512|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/HLADRB5Alveolar_Macrophages_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/HLADRB5Alveolar_Macrophages_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/HLADRB5Alveolar_Macrophages_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/HLADRB5Alveolar_Macrophages_against_bbja88chunk8-1.png)
