

# Two sample MR report

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## CDC42EP1_Monocyte (Mono) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3| -0.0109071| 0.1509764| 0.9540880|
|Weighted median           |    3|  0.0191675| 0.0112080| 0.0872376|
|Inverse variance weighted |    3|  0.0184977| 0.0091594| 0.0434311|
|Simple mode               |    3|  0.0204084| 0.0127891| 0.2516034|
|Weighted mode             |    3|  0.0204580| 0.0116516| 0.2212050|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.1019760|    1| 0.7494712|
|Inverse variance weighted | 0.1400491|    2| 0.9323709|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|     pval|
|---------------:|---------:|--------:|
|       0.0223594| 0.1145909| 0.877322|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        2.32e-05|              0|TRUE                     |    0.6480497|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/CDC42EP1Monocyte_Mono_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/CDC42EP1Monocyte_Mono_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/CDC42EP1Monocyte_Mono_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/CDC42EP1Monocyte_Mono_against_UKBb18436chunk8-1.png)
