

# Two sample MR report

---

## GRHPR_Macrophages against UKB-b-18436

Date: **13 January, 2026**

---

### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3| -0.0680857| 0.2247576| 0.8127434|
|Weighted median           |    3|  0.0376433| 0.0187175| 0.0443110|
|Inverse variance weighted |    3|  0.0340978| 0.0163851| 0.0374322|
|Simple mode               |    3|  0.0402210| 0.0230479| 0.2230839|
|Weighted mode             |    3|  0.0402210| 0.0224628| 0.2152485|

---

### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0025150|    1| 0.9600034|
|Inverse variance weighted | 0.2103152|    2| 0.9001826|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0453699| 0.0995279| 0.7277119|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        3.42e-05|              0|TRUE                     |    0.5786981|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/GRHPRMacrophages_against_UKBb18436chunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/GRHPRMacrophages_against_UKBb18436chunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/GRHPRMacrophages_against_UKBb18436chunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/GRHPRMacrophages_against_UKBb18436chunk8-1.png)
