

# Two sample MR report

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## CD52_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    6| 0.1489065| 0.1855860| 0.4673078|
|Weighted median           |    6| 0.0884159| 0.0187218| 0.0000023|
|Inverse variance weighted |    6| 0.0842328| 0.0148675| 0.0000000|
|Simple mode               |    6| 0.0934838| 0.0266972| 0.0172544|
|Weighted mode             |    6| 0.0934838| 0.0283229| 0.0214604|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.9467429|    4| 0.9177611|
|Inverse variance weighted | 1.0689684|    5| 0.9568134|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0252425| 0.0722025| 0.7442636|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        4.21e-05|              0|TRUE                     |    0.5451598|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/CD52Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/CD52Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/CD52Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/CD52Macrophages_against_UKBb18436chunk8-1.png)
