

# Two sample MR report

---

## HLA-DRB5_Macrophages against UKB-b-18436

Date: **13 January, 2026**

---

### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   15| -0.1734050| 0.0912260| 0.0797247|
|Weighted median           |   15|  0.0315134| 0.0168587| 0.0615851|
|Inverse variance weighted |   15|  0.0349861| 0.0165018| 0.0339943|
|Simple mode               |   15|  0.0599476| 0.0313554| 0.0765781|
|Weighted mode             |   15|  0.0437437| 0.0263585| 0.1192266|

---

### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 25.77724|   13| 0.0182099|
|Inverse variance weighted | 36.38913|   14| 0.0009122|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0786377| 0.0339923| 0.0377092|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001546|              0|TRUE                     |    0.2428319|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/HLADRB5Macrophages_against_UKBb18436chunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/HLADRB5Macrophages_against_UKBb18436chunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/HLADRB5Macrophages_against_UKBb18436chunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/HLADRB5Macrophages_against_UKBb18436chunk8-1.png)
