

# Two sample MR report

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## RAD51C_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   20| -0.0137519| 0.0780920| 0.8621830|
|Weighted median           |   20| -0.0312543| 0.0068492| 0.0000050|
|Inverse variance weighted |   20| -0.0194729| 0.0063589| 0.0021963|
|Simple mode               |   20| -0.0354172| 0.0101002| 0.0023598|
|Weighted mode             |   20| -0.0354172| 0.0091625| 0.0010418|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 34.14750|   18| 0.0120775|
|Inverse variance weighted | 34.15775|   19| 0.0176057|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|      -0.0039506| 0.053736| 0.9422045|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0002177|              0|TRUE                     |    0.1631703|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/RAD51CMacrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/RAD51CMacrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/RAD51CMacrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/RAD51CMacrophages_against_UKBb18436chunk8-1.png)
