

# Two sample MR report

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## TUFM_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   20| 0.0519424| 0.1041005| 0.6238478|
|Weighted median           |   20| 0.0480402| 0.0095250| 0.0000005|
|Inverse variance weighted |   20| 0.0349838| 0.0068300| 0.0000003|
|Simple mode               |   20| 0.0514741| 0.0161754| 0.0049056|
|Weighted mode             |   20| 0.0511465| 0.0150605| 0.0030313|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 19.37751|   18| 0.3689312|
|Inverse variance weighted | 19.40621|   19| 0.4310700|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       -0.006842| 0.0419045| 0.8721194|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0004315|              0|TRUE                     |    0.0492263|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/TUFMMacrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/TUFMMacrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/TUFMMacrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/TUFMMacrophages_against_UKBb18436chunk8-1.png)
