

# Two sample MR report

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## LRRC46_Epithelial against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    9| 0.1752526| 0.1512267| 0.2845091|
|Weighted median           |    9| 0.0228380| 0.0197554| 0.2476648|
|Inverse variance weighted |    9| 0.0393484| 0.0154155| 0.0106946|
|Simple mode               |    9| 0.0198902| 0.0248513| 0.4466119|
|Weighted mode             |    9| 0.0203808| 0.0226121| 0.3937402|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 6.389416|    7| 0.4950843|
|Inverse variance weighted | 7.205520|    8| 0.5146299|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0640589| 0.0709098| 0.3963443|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001397|              0|TRUE                     |    0.2632388|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/LRRC46Epithelial_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/LRRC46Epithelial_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/LRRC46Epithelial_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/LRRC46Epithelial_against_bbja88chunk8-1.png)
