

# Two sample MR report

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## UCP2_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    7|  0.4825290| 0.3214911| 0.1936773|
|Weighted median           |    7| -0.0735456| 0.0421945| 0.0813312|
|Inverse variance weighted |    7| -0.0632310| 0.0320277| 0.0483521|
|Simple mode               |    7| -0.1294785| 0.0653542| 0.0948686|
|Weighted mode             |    7| -0.1294785| 0.0690347| 0.1098294|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 2.107037|    5| 0.8341449|
|Inverse variance weighted | 5.017736|    6| 0.5415404|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.2043145| 0.1197569| 0.1487072|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001814|              0|TRUE                     |    0.2010811|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/UCP2Macrophages_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/UCP2Macrophages_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/UCP2Macrophages_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/UCP2Macrophages_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
