

# Two sample MR report

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## HLA-DQB2_Epithelial against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    3| 0.5700899| 0.2477036| 0.2609434|
|Weighted median           |    3| 0.0719060| 0.0248973| 0.0038756|
|Inverse variance weighted |    3| 0.0907108| 0.0200246| 0.0000059|
|Simple mode               |    3| 0.0666523| 0.0292402| 0.1502543|
|Weighted mode             |    3| 0.0669258| 0.0271257| 0.1324180|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.1509626|    1| 0.6976172|
|Inverse variance weighted | 3.9088895|    2| 0.1416431|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.3763422| 0.1941372| 0.3031897|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        1.99e-05|          1e-07|TRUE                     |    0.6934505|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/HLADQB2Epithelial_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/HLADQB2Epithelial_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/HLADQB2Epithelial_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/HLADQB2Epithelial_against_bbja88chunk8-1.png)
