

# Two sample MR report

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## NOXA1_Epithelial against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3| -0.0689443| 0.6615856| 0.9338960|
|Weighted median           |    3| -0.0529977| 0.0193349| 0.0061244|
|Inverse variance weighted |    3| -0.0537386| 0.0157202| 0.0006298|
|Simple mode               |    3| -0.0527460| 0.0219629| 0.1383030|
|Weighted mode             |    3| -0.0527171| 0.0208250| 0.1269957|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0088840|    1| 0.9249065|
|Inverse variance weighted | 0.0094126|    2| 0.9953048|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0099954| 0.4347686| 0.9853665|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        4.12e-05|              0|TRUE                     |    0.5463049|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/NOXA1Epithelial_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/NOXA1Epithelial_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/NOXA1Epithelial_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/NOXA1Epithelial_against_bbja88chunk8-1.png)
