

# Two sample MR report

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## CBWD1_T Proliferating against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    5|  0.4792853| 0.5403459| 0.4404137|
|Weighted median           |    5| -0.1428369| 0.0339292| 0.0000256|
|Inverse variance weighted |    5| -0.1267566| 0.0254594| 0.0000006|
|Simple mode               |    5| -0.1487270| 0.0453950| 0.0306074|
|Weighted mode             |    5| -0.1487270| 0.0472769| 0.0346514|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.1768966|    3| 0.9812299|
|Inverse variance weighted | 1.4376403|    4| 0.8376273|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|      -0.3388562| 0.301788| 0.3432631|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        4.48e-05|              0|TRUE                     |    0.5320408|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/CBWD1T_Proliferating_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/CBWD1T_Proliferating_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/CBWD1T_Proliferating_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/CBWD1T_Proliferating_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
