

# Two sample MR report

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## ERAP2_Dendritic Cell (DC) against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   10| -0.0758239| 0.1484236| 0.6232437|
|Weighted median           |   10| -0.0599913| 0.0199963| 0.0026987|
|Inverse variance weighted |   10| -0.0545933| 0.0154794| 0.0004206|
|Simple mode               |   10| -0.0638160| 0.0282943| 0.0505521|
|Weighted mode             |   10| -0.0632972| 0.0283322| 0.0523444|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.904565|    8| 0.9837991|
|Inverse variance weighted | 1.925251|    9| 0.9925952|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0138716| 0.0964479| 0.8891954|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0003614|              0|TRUE                     |    0.0708489|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/ERAP2Dendritic_Cell_DC_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/ERAP2Dendritic_Cell_DC_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/ERAP2Dendritic_Cell_DC_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/ERAP2Dendritic_Cell_DC_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
