

# Two sample MR report

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## GBP3_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   24| -0.0269549| 0.0227944| 0.2496207|
|Weighted median           |   24| -0.0128944| 0.0052376| 0.0138215|
|Inverse variance weighted |   24| -0.0102877| 0.0039472| 0.0091509|
|Simple mode               |   24| -0.0158393| 0.0094085| 0.1058025|
|Weighted mode             |   24| -0.0149187| 0.0083990| 0.0889251|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 16.62494|   22| 0.7837079|
|Inverse variance weighted | 17.17611|   23| 0.8005207|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|        0.011241| 0.0151412| 0.4656914|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0009313|              0|TRUE                     |    0.0036794|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/GBP3Epithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/GBP3Epithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/GBP3Epithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/GBP3Epithelial_against_UKBb18436chunk8-1.png)
