

# Two sample MR report

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## DBI_Dendritic Cell (DC) against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    4| 0.2445055| 0.7912567| 0.7865339|
|Weighted median           |    4| 0.2361137| 0.0520639| 0.0000058|
|Inverse variance weighted |    4| 0.2373512| 0.0412281| 0.0000000|
|Simple mode               |    4| 0.2335972| 0.0626330| 0.0335836|
|Weighted mode             |    4| 0.2345654| 0.0658695| 0.0377916|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.1065463|    2| 0.9481210|
|Inverse variance weighted | 0.1066283|    3| 0.9910303|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|     pval|
|---------------:|---------:|--------:|
|      -0.0035414| 0.3911438| 0.993598|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        7.03e-05|              0|TRUE                     |    0.4348043|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/DBIDendritic_Cell_DC_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/DBIDendritic_Cell_DC_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/DBIDendritic_Cell_DC_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/DBIDendritic_Cell_DC_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
