

# Two sample MR report

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## RPS26_Monocyte (Mono) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    8| -0.0125031| 0.0528195| 0.8207535|
|Weighted median           |    8| -0.0548966| 0.0114711| 0.0000017|
|Inverse variance weighted |    8| -0.0546526| 0.0090743| 0.0000000|
|Simple mode               |    8| -0.0457516| 0.0175097| 0.0347645|
|Weighted mode             |    8| -0.0514307| 0.0169054| 0.0187867|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 2.433656|    6| 0.8758175|
|Inverse variance weighted | 3.089812|    7| 0.8765714|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0200845| 0.0247947| 0.4488458|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0005217|              0|TRUE                     |    0.0309227|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/RPS26Monocyte_Mono_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/RPS26Monocyte_Mono_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/RPS26Monocyte_Mono_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/RPS26Monocyte_Mono_against_UKBb18436chunk8-1.png)
