

# Two sample MR report

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## STXBP2_Alveolar Macrophages against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3| -0.1945762| 0.5035978| 0.7652761|
|Weighted median           |    3| -0.1032509| 0.0372880| 0.0056226|
|Inverse variance weighted |    3| -0.1019969| 0.0304242| 0.0008009|
|Simple mode               |    3| -0.1045001| 0.0422845| 0.1320609|
|Weighted mode             |    3| -0.1056275| 0.0418084| 0.1274045|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0272312|    1| 0.8689293|
|Inverse variance weighted | 0.0611506|    2| 0.9698874|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0553234| 0.3003892| 0.8840516|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        4.53e-05|              0|TRUE                     |    0.5273834|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/STXBP2Alveolar_Macrophages_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/STXBP2Alveolar_Macrophages_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/STXBP2Alveolar_Macrophages_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/STXBP2Alveolar_Macrophages_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
