

# Two sample MR report

---

## LGALS2_Macrophages against UKB-b-18436

Date: **13 January, 2026**

---

### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   10| 0.0575745| 0.0556144| 0.3308324|
|Weighted median           |   10| 0.0242033| 0.0076823| 0.0016298|
|Inverse variance weighted |   10| 0.0239894| 0.0061638| 0.0000994|
|Simple mode               |   10| 0.0267225| 0.0111694| 0.0403934|
|Weighted mode             |   10| 0.0262669| 0.0116290| 0.0502806|

---

### Heterogeneity tests


|method                    |       Q| Q_df|    Q_pval|
|:-------------------------|-------:|----:|---------:|
|MR Egger                  | 1.10475|    8| 0.9974960|
|Inverse variance weighted | 1.47397|    9| 0.9973353|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0212427| 0.0349597| 0.5602783|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        0.000311|              0|TRUE                     |    0.0938714|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/LGALS2Macrophages_against_UKBb18436chunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/LGALS2Macrophages_against_UKBb18436chunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/LGALS2Macrophages_against_UKBb18436chunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/LGALS2Macrophages_against_UKBb18436chunk8-1.png)
