

# Two sample MR report

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## SPATA13_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    4|  0.0640319| 0.1841871| 0.7612841|
|Weighted median           |    4| -0.0381862| 0.0161511| 0.0180636|
|Inverse variance weighted |    4| -0.0420919| 0.0137994| 0.0022863|
|Simple mode               |    4| -0.0359812| 0.0219067| 0.1990324|
|Weighted mode             |    4| -0.0359812| 0.0217899| 0.1972484|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0841956|    2| 0.9587760|
|Inverse variance weighted | 0.4180459|    3| 0.9364899|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|      -0.0565254| 0.097829| 0.6217845|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        3.51e-05|              0|TRUE                     |    0.5756153|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/SPATA13Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/SPATA13Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/SPATA13Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/SPATA13Macrophages_against_UKBb18436chunk8-1.png)
