

# Two sample MR report

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## HOMER2_Interstitial Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    5| -0.0136703| 0.0920242| 0.8913310|
|Weighted median           |    5|  0.0325688| 0.0073274| 0.0000088|
|Inverse variance weighted |    5|  0.0325870| 0.0059190| 0.0000000|
|Simple mode               |    5|  0.0352395| 0.0096228| 0.0215411|
|Weighted mode             |    5|  0.0297997| 0.0095193| 0.0351700|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0406301|    3| 0.9978482|
|Inverse variance weighted | 0.2943512|    4| 0.9901759|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0513385| 0.1019213| 0.6491285|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        8.73e-05|              0|TRUE                     |    0.3809127|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/HOMER2Interstitial_Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/HOMER2Interstitial_Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/HOMER2Interstitial_Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/HOMER2Interstitial_Macrophages_against_UKBb18436chunk8-1.png)
