

# Two sample MR report

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## ERAP2_Alveolar Macrophages against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   12| -0.0357609| 0.1031996| 0.7361313|
|Weighted median           |   12| -0.0489224| 0.0148117| 0.0009567|
|Inverse variance weighted |   12| -0.0427288| 0.0117703| 0.0002832|
|Simple mode               |   12| -0.0527381| 0.0229985| 0.0425445|
|Weighted mode             |   12| -0.0525364| 0.0238138| 0.0495524|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.765829|   10| 0.9978403|
|Inverse variance weighted | 1.770447|   11| 0.9991540|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0056257| 0.0827772| 0.9471554|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0005197|              0|TRUE                     |    0.0302059|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/ERAP2Alveolar_Macrophages_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/ERAP2Alveolar_Macrophages_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/ERAP2Alveolar_Macrophages_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/ERAP2Alveolar_Macrophages_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
