

# Two sample MR report

---

## CFD_Macrophages against UKB-b-18436

Date: **13 January, 2026**

---

### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   14| 0.0176823| 0.0472512| 0.7147703|
|Weighted median           |   14| 0.0125080| 0.0087441| 0.1525883|
|Inverse variance weighted |   14| 0.0152117| 0.0066102| 0.0213784|
|Simple mode               |   14| 0.0106018| 0.0146080| 0.4808512|
|Weighted mode             |   14| 0.0104261| 0.0152882| 0.5072274|

---

### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 8.038281|   12| 0.7821318|
|Inverse variance weighted | 8.041069|   13| 0.8409144|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       -0.001413| 0.0267596| 0.9587561|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001832|              0|TRUE                     |    0.1990212|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/CFDMacrophages_against_UKBb18436chunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/CFDMacrophages_against_UKBb18436chunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/CFDMacrophages_against_UKBb18436chunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/CFDMacrophages_against_UKBb18436chunk8-1.png)
