

# Two sample MR report

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## DBI_Conventional Dendritic Cell against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    4| 0.1945327| 0.9986024| 0.8635406|
|Weighted median           |    4| 0.2102729| 0.0470850| 0.0000080|
|Inverse variance weighted |    4| 0.2103471| 0.0370301| 0.0000000|
|Simple mode               |    4| 0.2211116| 0.0611177| 0.0363036|
|Weighted mode             |    4| 0.2194651| 0.0651183| 0.0434028|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.1491156|    2| 0.9281538|
|Inverse variance weighted | 0.1493667|    3| 0.9853168|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0087573| 0.5526026| 0.9887949|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        3.12e-05|              0|TRUE                     |    0.6051167|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/DBIConventional_Dendritic_Cell_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/DBIConventional_Dendritic_Cell_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/DBIConventional_Dendritic_Cell_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/DBIConventional_Dendritic_Cell_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
