

# Two sample MR report

---

## HLA-DRB5_Conventional Dendritic Cell against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

---

### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    9| 0.1291803| 0.1172284| 0.3069219|
|Weighted median           |    9| 0.0698792| 0.0315722| 0.0268760|
|Inverse variance weighted |    9| 0.0675502| 0.0256069| 0.0083405|
|Simple mode               |    9| 0.0840593| 0.0452943| 0.1005700|
|Weighted mode             |    9| 0.0773657| 0.0446673| 0.1215045|

---

### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 2.328063|    7| 0.9394785|
|Inverse variance weighted | 2.618301|    8| 0.9559860|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0337003| 0.0625543| 0.6067679|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        9.92e-05|              0|TRUE                     |     0.344284|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/HLADRB5Conventional_Dendritic_Cell_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/HLADRB5Conventional_Dendritic_Cell_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/HLADRB5Conventional_Dendritic_Cell_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/HLADRB5Conventional_Dendritic_Cell_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
