

# Two sample MR report

---

## SPATA20_Epithelial against UKB-b-18436

Date: **13 January, 2026**

---

### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    9| 0.0249057| 0.0277420| 0.3991369|
|Weighted median           |    9| 0.0253116| 0.0084800| 0.0028372|
|Inverse variance weighted |    9| 0.0258271| 0.0067480| 0.0001295|
|Simple mode               |    9| 0.0239020| 0.0122779| 0.0874298|
|Weighted mode             |    9| 0.0239999| 0.0119406| 0.0792860|

---

### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.3100246|    7| 0.9998882|
|Inverse variance weighted | 0.3111971|    8| 0.9999784|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0006668| 0.0194721| 0.9736403|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        6.36e-05|              0|TRUE                     |    0.4501862|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/SPATA20Epithelial_against_UKBb18436chunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/SPATA20Epithelial_against_UKBb18436chunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/SPATA20Epithelial_against_UKBb18436chunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/SPATA20Epithelial_against_UKBb18436chunk8-1.png)
