

# Two sample MR report

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## MARVELD1_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   32| -0.0065547| 0.0289786| 0.8225867|
|Weighted median           |   32|  0.0063510| 0.0038657| 0.1003999|
|Inverse variance weighted |   32|  0.0056583| 0.0028355| 0.0459864|
|Simple mode               |   32|  0.0068631| 0.0072100| 0.3485187|
|Weighted mode             |   32|  0.0068631| 0.0078550| 0.3889849|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 15.48761|   30| 0.9866786|
|Inverse variance weighted | 15.66694|   31| 0.9899378|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0104837| 0.0247561| 0.6749655|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0006463|              0|TRUE                     |    0.0155878|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/MARVELD1Epithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/MARVELD1Epithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/MARVELD1Epithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/MARVELD1Epithelial_against_UKBb18436chunk8-1.png)
