

# Two sample MR report

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## LRRC4_Epithelial against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    6| 0.0011290| 0.0614954| 0.9862318|
|Weighted median           |    6| 0.0389259| 0.0197887| 0.0491744|
|Inverse variance weighted |    6| 0.0468901| 0.0161555| 0.0037029|
|Simple mode               |    6| 0.0422434| 0.0284852| 0.1981841|
|Weighted mode             |    6| 0.0387774| 0.0243954| 0.1728080|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.3778881|    4| 0.9842469|
|Inverse variance weighted | 0.9726815|    5| 0.9647390|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0225463| 0.0292342| 0.4836011|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001506|              0|TRUE                     |    0.2438358|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/LRRC4Epithelial_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/LRRC4Epithelial_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/LRRC4Epithelial_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/LRRC4Epithelial_against_bbja88chunk8-1.png)
