

# Two sample MR report

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## SMDT1_Epithelial against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   13| -0.0552236| 0.0793904| 0.5011134|
|Weighted median           |   13|  0.0218717| 0.0177027| 0.2166455|
|Inverse variance weighted |   13|  0.0267059| 0.0132292| 0.0435170|
|Simple mode               |   13|  0.0154074| 0.0258431| 0.5621264|
|Weighted mode             |   13|  0.0327158| 0.0245374| 0.2071910|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 3.048183|   11| 0.9900737|
|Inverse variance weighted | 4.143589|   12| 0.9807037|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|    pval|
|---------------:|---------:|-------:|
|       0.0360454| 0.0344399| 0.31773|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0005714|              0|TRUE                     |    0.0229562|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/SMDT1Epithelial_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/SMDT1Epithelial_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/SMDT1Epithelial_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/SMDT1Epithelial_against_bbja88chunk8-1.png)
