

# Two sample MR report

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## MXRA7_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    5| -0.0496842| 0.3421630| 0.8937551|
|Weighted median           |    5| -0.0561522| 0.0226901| 0.0133330|
|Inverse variance weighted |    5| -0.0567957| 0.0188701| 0.0026140|
|Simple mode               |    5| -0.0559318| 0.0280396| 0.1168159|
|Weighted mode             |    5| -0.0559098| 0.0278695| 0.1153067|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0073264|    3| 0.9998336|
|Inverse variance weighted | 0.0077597|    4| 0.9999925|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0085113| 0.4088921| 0.9846999|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        3.98e-05|              0|TRUE                     |    0.5502597|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/MXRA7Macrophages_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/MXRA7Macrophages_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/MXRA7Macrophages_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/MXRA7Macrophages_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
