

# Two sample MR report

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## NME5_T Proliferating against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    4| -0.0203320| 0.2805434| 0.9488206|
|Weighted median           |    4|  0.0171862| 0.0088647| 0.0525338|
|Inverse variance weighted |    4|  0.0173177| 0.0077508| 0.0254621|
|Simple mode               |    4|  0.0164060| 0.0115842| 0.2516798|
|Weighted mode             |    4|  0.0163914| 0.0109882| 0.2325791|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0018640|    2| 0.9990684|
|Inverse variance weighted | 0.0198881|    3| 0.9992585|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0564696| 0.4206184| 0.9054931|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        4.48e-05|              0|TRUE                     |    0.5251375|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/NME5T_Proliferating_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/NME5T_Proliferating_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/NME5T_Proliferating_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/NME5T_Proliferating_against_UKBb18436chunk8-1.png)
