

# Two sample MR report

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## LIMS2_Alveolar Macrophages against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    5| 0.0238823| 0.1125070| 0.8454982|
|Weighted median           |    5| 0.0321888| 0.0190233| 0.0906324|
|Inverse variance weighted |    5| 0.0351022| 0.0153648| 0.0223370|
|Simple mode               |    5| 0.0310177| 0.0253730| 0.2886352|
|Weighted mode             |    5| 0.0312892| 0.0233761| 0.2517439|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.2637508|    3| 0.9666953|
|Inverse variance weighted | 0.2738852|    4| 0.9914370|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0117781| 0.1169975| 0.9261635|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|         9.4e-05|              0|TRUE                     |    0.3566832|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/LIMS2Alveolar_Macrophages_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/LIMS2Alveolar_Macrophages_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/LIMS2Alveolar_Macrophages_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/LIMS2Alveolar_Macrophages_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
