

# Two sample MR report

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## ZNF506_Alveolar Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    5| 0.0351818| 0.1342129| 0.8101870|
|Weighted median           |    5| 0.0299093| 0.0087003| 0.0005866|
|Inverse variance weighted |    5| 0.0247809| 0.0062798| 0.0000794|
|Simple mode               |    5| 0.0340705| 0.0128082| 0.0563870|
|Weighted mode             |    5| 0.0338747| 0.0134457| 0.0654008|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 3.675137|    3| 0.2987476|
|Inverse variance weighted | 3.682514|    4| 0.4506742|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0112988| 0.1456051| 0.9430326|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        5.05e-05|              0|TRUE                     |    0.5059142|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/ZNF506Alveolar_Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/ZNF506Alveolar_Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/ZNF506Alveolar_Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/ZNF506Alveolar_Macrophages_against_UKBb18436chunk8-1.png)
