

# Two sample MR report

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## SH3BGRL3_Alveolar Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    4|  0.0139109| 0.1854609| 0.9470363|
|Weighted median           |    4| -0.0844488| 0.0201513| 0.0000278|
|Inverse variance weighted |    4| -0.0830394| 0.0164311| 0.0000004|
|Simple mode               |    4| -0.0895811| 0.0265110| 0.0431225|
|Weighted mode             |    4| -0.0890586| 0.0239946| 0.0340037|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.1311235|    2| 0.9365412|
|Inverse variance weighted | 0.4065568|    3| 0.9388847|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0437053| 0.0832771| 0.6520826|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        4.49e-05|              0|TRUE                     |    0.5309391|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/SH3BGRL3Alveolar_Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/SH3BGRL3Alveolar_Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/SH3BGRL3Alveolar_Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/SH3BGRL3Alveolar_Macrophages_against_UKBb18436chunk8-1.png)
