

# Two sample MR report

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## HLA-DQA1_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   66| -0.0338057| 0.0290285| 0.2485160|
|Weighted median           |   66|  0.0541008| 0.0047087| 0.0000000|
|Inverse variance weighted |   66|  0.0507359| 0.0054137| 0.0000000|
|Simple mode               |   66|  0.0774242| 0.0121524| 0.0000000|
|Weighted mode             |   66|  0.0717594| 0.0133353| 0.0000011|

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### Heterogeneity tests


|method                    |        Q| Q_df| Q_pval|
|:-------------------------|--------:|----:|------:|
|MR Egger                  | 237.7726|   64|      0|
|Inverse variance weighted | 270.2950|   65|      0|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0564437| 0.0190772| 0.0043261|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0008476|        1.2e-06|TRUE                     |    0.0075191|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/HLADQA1Epithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/HLADQA1Epithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/HLADQA1Epithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/HLADQA1Epithelial_against_UKBb18436chunk8-1.png)
