

# Two sample MR report

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## MUC16_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    3| 0.0514032| 0.1354443| 0.7690828|
|Weighted median           |    3| 0.0692610| 0.0195596| 0.0003986|
|Inverse variance weighted |    3| 0.0703319| 0.0156316| 0.0000068|
|Simple mode               |    3| 0.0689319| 0.0217024| 0.0864616|
|Weighted mode             |    3| 0.0687191| 0.0241949| 0.1048298|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0094188|    1| 0.9226862|
|Inverse variance weighted | 0.0292133|    2| 0.9854995|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0089301| 0.0634725| 0.9110162|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        7.45e-05|              0|TRUE                     |    0.4178731|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/MUC16Epithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/MUC16Epithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/MUC16Epithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/MUC16Epithelial_against_UKBb18436chunk8-1.png)
