

# Two sample MR report

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## WDSUB1_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3| -0.1280633| 0.2384628| 0.6862506|
|Weighted median           |    3|  0.0357837| 0.0157833| 0.0233784|
|Inverse variance weighted |    3|  0.0407379| 0.0122042| 0.0008437|
|Simple mode               |    3|  0.0342010| 0.0176507| 0.1922579|
|Weighted mode             |    3|  0.0340990| 0.0185390| 0.2072420|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.1910134|    1| 0.6620745|
|Inverse variance weighted | 0.6934129|    2| 0.7070128|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0981795| 0.1385149| 0.6074548|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        2.93e-05|              0|TRUE                     |    0.6108974|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/WDSUB1Epithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/WDSUB1Epithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/WDSUB1Epithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/WDSUB1Epithelial_against_UKBb18436chunk8-1.png)
