

# Two sample MR report

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## SMDT1_Monocyte (Mono) against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   11| -0.0648552| 0.1052106| 0.5528800|
|Weighted median           |   11| -0.0407643| 0.0198039| 0.0395516|
|Inverse variance weighted |   11| -0.0364925| 0.0165903| 0.0278332|
|Simple mode               |   11| -0.0474369| 0.0310874| 0.1580155|
|Weighted mode             |   11| -0.0431110| 0.0306535| 0.1899131|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 3.593789|    9| 0.9360612|
|Inverse variance weighted | 3.668316|   10| 0.9610720|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|       0.0169112| 0.061947| 0.7910174|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        0.000763|              0|TRUE                     |    0.0085512|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/SMDT1Monocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/SMDT1Monocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/SMDT1Monocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/SMDT1Monocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
