

# Two sample MR report

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## ZSWIM7_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   14|  0.1502330| 0.1323248| 0.2784031|
|Weighted median           |   14| -0.1257617| 0.0229676| 0.0000000|
|Inverse variance weighted |   14| -0.1188743| 0.0165715| 0.0000000|
|Simple mode               |   14| -0.1457545| 0.0341318| 0.0009121|
|Weighted mode             |   14| -0.1439372| 0.0363735| 0.0016391|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.9896823|   12| 0.9999866|
|Inverse variance weighted | 5.1914634|   13| 0.9707328|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.1381247| 0.0673837| 0.0628912|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0003432|              0|TRUE                     |    0.0804945|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/ZSWIM7Macrophages_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/ZSWIM7Macrophages_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/ZSWIM7Macrophages_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/ZSWIM7Macrophages_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
