

# Two sample MR report

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## HLA-DQA2_Alveolar Macrophages against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   14| -0.0976404| 0.1220028| 0.4390867|
|Weighted median           |   14|  0.0197509| 0.0169844| 0.2448765|
|Inverse variance weighted |   14|  0.0271214| 0.0126525| 0.0320680|
|Simple mode               |   14|  0.0195997| 0.0294031| 0.5166935|
|Weighted mode             |   14|  0.0195997| 0.0272892| 0.4853302|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 6.843767|   12| 0.8677630|
|Inverse variance weighted | 7.900877|   13| 0.8499974|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0940331| 0.0914578| 0.3241543|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        0.000115|              0|TRUE                     |    0.3087507|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/HLADQA2Alveolar_Macrophages_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/HLADQA2Alveolar_Macrophages_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/HLADQA2Alveolar_Macrophages_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/HLADQA2Alveolar_Macrophages_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
