

# Two sample MR report

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## CST3_Monocyte (Mono) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    5| -0.1045871| 0.3917289| 0.8067793|
|Weighted median           |    5| -0.0364857| 0.0177010| 0.0392824|
|Inverse variance weighted |    5| -0.0371697| 0.0146814| 0.0113494|
|Simple mode               |    5| -0.0381224| 0.0224837| 0.1652130|
|Weighted mode             |    5| -0.0388507| 0.0230563| 0.1672640|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0448690|    3| 0.9975060|
|Inverse variance weighted | 0.0745298|    4| 0.9993227|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|     pval|
|---------------:|---------:|--------:|
|       0.0296813| 0.1723424| 0.874225|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        7.92e-05|              0|TRUE                     |    0.3978323|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/CST3Monocyte_Mono_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/CST3Monocyte_Mono_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/CST3Monocyte_Mono_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/CST3Monocyte_Mono_against_UKBb18436chunk8-1.png)
