

# Two sample MR report

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## PIGP_Epithelial against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    6|  0.0366790| 0.1529471| 0.8222619|
|Weighted median           |    6| -0.0528184| 0.0185639| 0.0044381|
|Inverse variance weighted |    6| -0.0541256| 0.0147640| 0.0002463|
|Simple mode               |    6| -0.0562616| 0.0252983| 0.0767481|
|Weighted mode             |    6| -0.0544942| 0.0263104| 0.0930974|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.5581236|    4| 0.9676015|
|Inverse variance weighted | 0.9139180|    5| 0.9692059|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|     pval|
|---------------:|---------:|--------:|
|      -0.0410944| 0.0688942| 0.582969|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        5.96e-05|              0|TRUE                     |    0.4656891|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/PIGPEpithelial_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/PIGPEpithelial_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/PIGPEpithelial_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/PIGPEpithelial_against_bbja88chunk8-1.png)
