

# Two sample MR report

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## CTD-2270L9.4_Epithelial against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3|  0.0506011| 0.2475228| 0.8716245|
|Weighted median           |    3| -0.0550370| 0.0193624| 0.0044766|
|Inverse variance weighted |    3| -0.0578511| 0.0146722| 0.0000805|
|Simple mode               |    3| -0.0539140| 0.0224847| 0.1386527|
|Weighted mode             |    3| -0.0537732| 0.0220261| 0.1346980|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0045014|    1| 0.9465079|
|Inverse variance weighted | 0.1971543|    2| 0.9061258|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0750413| 0.1709671| 0.7366917|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        3.68e-05|              0|TRUE                     |    0.5705858|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/CTD2270L94Epithelial_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/CTD2270L94Epithelial_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/CTD2270L94Epithelial_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/CTD2270L94Epithelial_against_bbja88chunk8-1.png)
