

# Two sample MR report

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## TMEM220_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    5| -0.1046219| 0.5982020| 0.8723005|
|Weighted median           |    5|  0.1481473| 0.0419747| 0.0004164|
|Inverse variance weighted |    5|  0.1451072| 0.0333307| 0.0000134|
|Simple mode               |    5|  0.1588494| 0.0489551| 0.0315305|
|Weighted mode             |    5|  0.1587105| 0.0534286| 0.0411233|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0251973|    3| 0.9989442|
|Inverse variance weighted | 0.2000180|    4| 0.9953203|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.1057091| 0.2528227| 0.7039882|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        9.66e-05|              0|TRUE                     |    0.3545436|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/TMEM220Macrophages_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/TMEM220Macrophages_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/TMEM220Macrophages_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/TMEM220Macrophages_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
