

# Two sample MR report

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## BTN3A2_T Proliferating against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   28| 0.0995693| 0.0433072| 0.0297834|
|Weighted median           |   28| 0.0327170| 0.0049692| 0.0000000|
|Inverse variance weighted |   28| 0.0204087| 0.0057865| 0.0004204|
|Simple mode               |   28| 0.0326563| 0.0066865| 0.0000416|
|Weighted mode             |   28| 0.0328963| 0.0065651| 0.0000296|

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### Heterogeneity tests


|method                    |        Q| Q_df|   Q_pval|
|:-------------------------|--------:|----:|--------:|
|MR Egger                  | 65.00572|   26| 3.44e-05|
|Inverse variance weighted | 73.49862|   27| 3.50e-06|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0770654| 0.0418139| 0.0767502|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0003989|          1e-07|TRUE                     |    0.0598364|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/BTN3A2T_Proliferating_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/BTN3A2T_Proliferating_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/BTN3A2T_Proliferating_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/BTN3A2T_Proliferating_against_UKBb18436chunk8-1.png)
