

# Two sample MR report

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## HAGH_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    5| -0.0228346| 0.2810465| 0.9403612|
|Weighted median           |    5| -0.0441142| 0.0166715| 0.0081429|
|Inverse variance weighted |    5| -0.0439147| 0.0139726| 0.0016728|
|Simple mode               |    5| -0.0446134| 0.0216295| 0.1081311|
|Weighted mode             |    5| -0.0445713| 0.0221384| 0.1143674|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0590800|    3| 0.9962477|
|Inverse variance weighted | 0.0647198|    4| 0.9994876|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0083115| 0.1106739| 0.9448637|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        8.87e-05|              0|TRUE                     |    0.3729724|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/HAGHMacrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/HAGHMacrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/HAGHMacrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/HAGHMacrophages_against_UKBb18436chunk8-1.png)
