

# Two sample MR report

---

## HOMER2_Macrophages against UKB-b-18436

Date: **13 January, 2026**

---

### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   27| 0.0459016| 0.0249231| 0.0774098|
|Weighted median           |   27| 0.0215030| 0.0047982| 0.0000074|
|Inverse variance weighted |   27| 0.0192755| 0.0041677| 0.0000037|
|Simple mode               |   27| 0.0324253| 0.0096661| 0.0024496|
|Weighted mode             |   27| 0.0281807| 0.0090248| 0.0043619|

---

### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 41.84436|   25| 0.0186773|
|Inverse variance weighted | 43.80926|   26| 0.0158457|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|      -0.0232147| 0.021426| 0.2889336|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0003533|          1e-07|TRUE                     |    0.0766482|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/HOMER2Macrophages_against_UKBb18436chunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/HOMER2Macrophages_against_UKBb18436chunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/HOMER2Macrophages_against_UKBb18436chunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/HOMER2Macrophages_against_UKBb18436chunk8-1.png)
