

# Two sample MR report

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## CD84_Epithelial against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    5| 0.1087295| 0.0969450| 0.3437260|
|Weighted median           |    5| 0.0161430| 0.0138599| 0.2441293|
|Inverse variance weighted |    5| 0.0231811| 0.0112241| 0.0388959|
|Simple mode               |    5| 0.0195648| 0.0177600| 0.3324575|
|Weighted mode             |    5| 0.0168461| 0.0166792| 0.3696263|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.1925833|    3| 0.9787776|
|Inverse variance weighted | 0.9818694|    4| 0.9125326|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|      -0.0842505| 0.094832| 0.4397587|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        6.71e-05|              0|TRUE                     |    0.4366982|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/CD84Epithelial_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/CD84Epithelial_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/CD84Epithelial_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/CD84Epithelial_against_bbja88chunk8-1.png)
