

# Two sample MR report

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## KCNMA1_Alveolar Macrophages against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   11| -0.0871189| 0.0825735| 0.3189020|
|Weighted median           |   11| -0.0374848| 0.0107382| 0.0004816|
|Inverse variance weighted |   11| -0.0393237| 0.0082095| 0.0000017|
|Simple mode               |   11| -0.0361344| 0.0166293| 0.0548967|
|Weighted mode             |   11| -0.0361344| 0.0164462| 0.0526972|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.756475|    9| 0.9947597|
|Inverse variance weighted | 2.094852|   10| 0.9955601|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|     pval|
|---------------:|---------:|--------:|
|       0.0389416| 0.0669442| 0.575046|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        0.000234|              0|TRUE                     |    0.1477323|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/KCNMA1Alveolar_Macrophages_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/KCNMA1Alveolar_Macrophages_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/KCNMA1Alveolar_Macrophages_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/KCNMA1Alveolar_Macrophages_against_bbja88chunk8-1.png)
