

# Two sample MR report

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## HLA-DQA2_Conventional Dendritic Cell against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    3| 0.2528950| 1.5476050| 0.8968810|
|Weighted median           |    3| 0.1638141| 0.0695586| 0.0185202|
|Inverse variance weighted |    3| 0.1627887| 0.0560947| 0.0037075|
|Simple mode               |    3| 0.1646562| 0.0798552| 0.1753302|
|Weighted mode             |    3| 0.1649805| 0.0834916| 0.1868072|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0024782|    1| 0.9602964|
|Inverse variance weighted | 0.0058726|    2| 0.9970680|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0310862| 0.5335652| 0.9629516|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        3.25e-05|              0|TRUE                     |    0.5903087|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/HLADQA2Conventional_Dendritic_Cell_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/HLADQA2Conventional_Dendritic_Cell_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/HLADQA2Conventional_Dendritic_Cell_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/HLADQA2Conventional_Dendritic_Cell_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
