

# Two sample MR report

---

## TUFM_Conventional Dendritic Cell against UKB-b-18436

Date: **13 January, 2026**

---

### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   15| 0.1079742| 0.0853906| 0.2282599|
|Weighted median           |   15| 0.0374110| 0.0079771| 0.0000027|
|Inverse variance weighted |   15| 0.0315406| 0.0060454| 0.0000002|
|Simple mode               |   15| 0.0383872| 0.0121165| 0.0068400|
|Weighted mode             |   15| 0.0381307| 0.0119944| 0.0066937|

---

### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 11.23474|   13| 0.5911597|
|Inverse variance weighted | 12.03999|   14| 0.6030909|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0399241| 0.0444908| 0.3858457|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        0.000325|              0|TRUE                     |    0.0880532|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/TUFMConventional_Dendritic_Cell_against_UKBb18436chunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/TUFMConventional_Dendritic_Cell_against_UKBb18436chunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/TUFMConventional_Dendritic_Cell_against_UKBb18436chunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/TUFMConventional_Dendritic_Cell_against_UKBb18436chunk8-1.png)
