

# Two sample MR report

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## SPATA20_Dendritic Cell (DC) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    6| -0.0013673| 0.0918885| 0.9888405|
|Weighted median           |    6|  0.0170417| 0.0076151| 0.0252291|
|Inverse variance weighted |    6|  0.0155534| 0.0062576| 0.0129366|
|Simple mode               |    6|  0.0171863| 0.0105887| 0.1654998|
|Weighted mode             |    6|  0.0170975| 0.0097709| 0.1405498|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.573172|    4| 0.8136056|
|Inverse variance weighted | 1.607239|    5| 0.9003726|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0137729| 0.0746208| 0.8625448|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        9.59e-05|              0|TRUE                     |    0.3523081|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/SPATA20Dendritic_Cell_DC_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/SPATA20Dendritic_Cell_DC_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/SPATA20Dendritic_Cell_DC_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/SPATA20Dendritic_Cell_DC_against_UKBb18436chunk8-1.png)
