

# Two sample MR report

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## SMIM6_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   21| -0.0489085| 0.0869141| 0.5802038|
|Weighted median           |   21| -0.0208111| 0.0069822| 0.0028769|
|Inverse variance weighted |   21| -0.0195302| 0.0053904| 0.0002910|
|Simple mode               |   21| -0.0206713| 0.0116304| 0.0907217|
|Weighted mode             |   21| -0.0201474| 0.0109716| 0.0812196|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 2.677790|   19| 0.9999958|
|Inverse variance weighted | 2.792486|   20| 0.9999978|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|     pval|
|---------------:|---------:|--------:|
|        0.014725| 0.0434791| 0.738574|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0003442|              0|TRUE                     |    0.0775596|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/SMIM6Epithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/SMIM6Epithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/SMIM6Epithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/SMIM6Epithelial_against_UKBb18436chunk8-1.png)
