

# Two sample MR report

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## LGMN_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    4|  2.4849551| 2.2204242| 0.3794506|
|Weighted median           |    4| -0.2101384| 0.0810155| 0.0094921|
|Inverse variance weighted |    4| -0.2652396| 0.0612215| 0.0000147|
|Simple mode               |    4| -0.2015319| 0.1067446| 0.1554639|
|Weighted mode             |    4| -0.1967588| 0.0972242| 0.1361605|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.4830042|    2| 0.7854472|
|Inverse variance weighted | 2.0182760|    3| 0.5686221|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.8483042| 0.6846348| 0.3410063|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        5.24e-05|              0|TRUE                     |     0.497327|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/LGMNMacrophages_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/LGMNMacrophages_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/LGMNMacrophages_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/LGMNMacrophages_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
