

# Two sample MR report

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## KCNMA1_Dendritic Cell (DC) against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3|  0.0962503| 0.2669399| 0.7796918|
|Weighted median           |    3| -0.0404543| 0.0216501| 0.0616857|
|Inverse variance weighted |    3| -0.0475584| 0.0179216| 0.0079619|
|Simple mode               |    3| -0.0399823| 0.0246826| 0.2466946|
|Weighted mode             |    3| -0.0400484| 0.0258951| 0.2620217|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.1434610|    1| 0.7048643|
|Inverse variance weighted | 0.4350056|    2| 0.8045254|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0953581| 0.1766059| 0.6848137|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        4.79e-05|              0|TRUE                     |    0.5135052|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/KCNMA1Dendritic_Cell_DC_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/KCNMA1Dendritic_Cell_DC_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/KCNMA1Dendritic_Cell_DC_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/KCNMA1Dendritic_Cell_DC_against_bbja88chunk8-1.png)
