

# Two sample MR report

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## SLC17A5_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   12| -0.0387206| 0.0601342| 0.5341273|
|Weighted median           |   12| -0.0223830| 0.0116160| 0.0539905|
|Inverse variance weighted |   12| -0.0189002| 0.0088285| 0.0322902|
|Simple mode               |   12| -0.0218697| 0.0171470| 0.2284346|
|Weighted mode             |   12| -0.0212169| 0.0159371| 0.2100274|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 5.923537|   10| 0.8216459|
|Inverse variance weighted | 6.034568|   11| 0.8710478|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0147733| 0.0443359| 0.7458539|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001391|              0|TRUE                     |    0.2625778|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/SLC17A5Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/SLC17A5Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/SLC17A5Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/SLC17A5Macrophages_against_UKBb18436chunk8-1.png)
