

# Two sample MR report

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## WBSCR27_Dendritic Cell (DC) against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    4| 0.2146887| 0.2686871| 0.5080872|
|Weighted median           |    4| 0.0628498| 0.0120310| 0.0000002|
|Inverse variance weighted |    4| 0.0612071| 0.0087768| 0.0000000|
|Simple mode               |    4| 0.0655095| 0.0153625| 0.0236598|
|Weighted mode             |    4| 0.0654460| 0.0158122| 0.0256041|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0650112|    2| 0.9680170|
|Inverse variance weighted | 0.3916609|    3| 0.9419597|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.1487135| 0.2602012| 0.6253069|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        7.73e-05|          1e-07|TRUE                     |    0.4223157|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/WBSCR27Dendritic_Cell_DC_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/WBSCR27Dendritic_Cell_DC_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/WBSCR27Dendritic_Cell_DC_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/WBSCR27Dendritic_Cell_DC_against_bbja88chunk8-1.png)
