

# Two sample MR report

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## DAW1_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    4| -0.1204727| 0.1680297| 0.5478155|
|Weighted median           |    4| -0.0368807| 0.0131734| 0.0051161|
|Inverse variance weighted |    4| -0.0381231| 0.0112442| 0.0006977|
|Simple mode               |    4| -0.0351822| 0.0174796| 0.1376155|
|Weighted mode             |    4| -0.0359102| 0.0172720| 0.1291131|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.3357326|    2| 0.8454669|
|Inverse variance weighted | 0.5770009|    3| 0.9016767|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0444215| 0.0904364| 0.6719023|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        5.76e-05|              0|TRUE                     |    0.4734257|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/DAW1Epithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/DAW1Epithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/DAW1Epithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/DAW1Epithelial_against_UKBb18436chunk8-1.png)
