

# Two sample MR report

---

## C20orf96_Epithelial against UKB-b-18436

Date: **13 January, 2026**

---

### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   14| -0.0197612| 0.0442340| 0.6630175|
|Weighted median           |   14| -0.0170051| 0.0075033| 0.0234305|
|Inverse variance weighted |   14| -0.0114502| 0.0056725| 0.0435346|
|Simple mode               |   14| -0.0184695| 0.0118585| 0.1433558|
|Weighted mode             |   14| -0.0184695| 0.0123262| 0.1579167|

---

### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 5.246375|   12| 0.9492394|
|Inverse variance weighted | 5.282267|   13| 0.9684424|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|        se|     pval|
|---------------:|---------:|--------:|
|       0.0048671| 0.0256903| 0.852906|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0004208|              0|TRUE                     |    0.0509222|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/C20orf96Epithelial_against_UKBb18436chunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/C20orf96Epithelial_against_UKBb18436chunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/C20orf96Epithelial_against_UKBb18436chunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/C20orf96Epithelial_against_UKBb18436chunk8-1.png)
