

# Two sample MR report

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## ZNF880_Macrophages against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    4| -0.0497868| 0.2787991| 0.8747226|
|Weighted median           |    4| -0.0548977| 0.0203796| 0.0070650|
|Inverse variance weighted |    4| -0.0463051| 0.0169140| 0.0061874|
|Simple mode               |    4| -0.0592598| 0.0303323| 0.1457476|
|Weighted mode             |    4| -0.0584602| 0.0283777| 0.1314862|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.433809|    2| 0.4882614|
|Inverse variance weighted | 1.433965|    3| 0.6975927|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0019148| 0.1530473| 0.9911537|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        5.36e-05|              0|TRUE                     |    0.4894291|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/ZNF880Macrophages_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/ZNF880Macrophages_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/ZNF880Macrophages_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/ZNF880Macrophages_against_bbja88chunk8-1.png)
