

# Two sample MR report

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## NQO2_Monocyte (Mono) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   12| 0.1095553| 0.0621087| 0.1082129|
|Weighted median           |   12| 0.0400630| 0.0075967| 0.0000001|
|Inverse variance weighted |   12| 0.0366484| 0.0062468| 0.0000000|
|Simple mode               |   12| 0.0391868| 0.0106154| 0.0035539|
|Weighted mode             |   12| 0.0394135| 0.0101174| 0.0024954|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 11.52449|   10| 0.3181397|
|Inverse variance weighted | 13.12816|   11| 0.2850315|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0474319| 0.0402091| 0.2654482|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001993|              0|TRUE                     |    0.1847096|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/NQO2Monocyte_Mono_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/NQO2Monocyte_Mono_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/NQO2Monocyte_Mono_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/NQO2Monocyte_Mono_against_UKBb18436chunk8-1.png)
