

# Two sample MR report

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## PARK7_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   17|  0.0024827| 0.1438128| 0.9864539|
|Weighted median           |   17| -0.0283641| 0.0130872| 0.0302103|
|Inverse variance weighted |   17| -0.0211438| 0.0106627| 0.0473719|
|Simple mode               |   17| -0.0294899| 0.0215497| 0.1900790|
|Weighted mode             |   17| -0.0291677| 0.0200053| 0.1641901|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.972051|   15| 0.9999730|
|Inverse variance weighted | 1.999190|   16| 0.9999898|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0084535| 0.0513145| 0.8713483|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0002172|              0|TRUE                     |    0.1607542|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/PARK7Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/PARK7Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/PARK7Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/PARK7Macrophages_against_UKBb18436chunk8-1.png)
