

# Two sample MR report

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## HLA-DQB1_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   19|  0.0896110| 0.1301870| 0.5005337|
|Weighted median           |   19| -0.0578372| 0.0218658| 0.0081667|
|Inverse variance weighted |   19| -0.0417240| 0.0177156| 0.0185121|
|Simple mode               |   19| -0.0613130| 0.0385308| 0.1289571|
|Weighted mode             |   19| -0.0606713| 0.0376785| 0.1247431|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 5.551575|   17| 0.9957274|
|Inverse variance weighted | 6.588490|   18| 0.9931619|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|     pval|
|---------------:|---------:|--------:|
|      -0.0639772| 0.0628281| 0.322814|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0008543|              0|TRUE                     |    0.0054217|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/HLADQB1Macrophages_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/HLADQB1Macrophages_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/HLADQB1Macrophages_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/HLADQB1Macrophages_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
