

# Two sample MR report

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## AHDC1_Epithelial against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    3| 0.5912724| 1.1767876| 0.7035882|
|Weighted median           |    3| 0.0601389| 0.0307443| 0.0504532|
|Inverse variance weighted |    3| 0.0660506| 0.0252007| 0.0087676|
|Simple mode               |    3| 0.0571673| 0.0385671| 0.2764757|
|Weighted mode             |    3| 0.0554664| 0.0357622| 0.2610641|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.2128635|    1| 0.6445322|
|Inverse variance weighted | 0.4121549|    2| 0.8137701|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|      -0.6133322| 1.373889| 0.7327003|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|         2.5e-05|              0|TRUE                     |    0.6370432|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/AHDC1Epithelial_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/AHDC1Epithelial_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/AHDC1Epithelial_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/AHDC1Epithelial_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
