

# Two sample MR report

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## APP_Alveolar Macrophages against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    7| -0.2656804| 0.1986206| 0.2386334|
|Weighted median           |    7|  0.0699702| 0.0266292| 0.0085995|
|Inverse variance weighted |    7|  0.0511276| 0.0211680| 0.0157211|
|Simple mode               |    7|  0.0763557| 0.0327114| 0.0583029|
|Weighted mode             |    7|  0.0745172| 0.0372257| 0.0922000|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 4.580838|    5| 0.4691409|
|Inverse variance weighted | 7.149479|    6| 0.3072445|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.2384667| 0.1487908| 0.1699037|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        7.46e-05|              0|TRUE                     |    0.4136315|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/APPAlveolar_Macrophages_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/APPAlveolar_Macrophages_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/APPAlveolar_Macrophages_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/APPAlveolar_Macrophages_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
