

# Two sample MR report

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## EIF5A_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    5| 0.0986825| 0.0758390| 0.2841040|
|Weighted median           |    5| 0.0265422| 0.0138106| 0.0546222|
|Inverse variance weighted |    5| 0.0231672| 0.0114598| 0.0432170|
|Simple mode               |    5| 0.0263795| 0.0187419| 0.2320293|
|Weighted mode             |    5| 0.0295591| 0.0190629| 0.1959329|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.5150906|    3| 0.9155638|
|Inverse variance weighted | 1.5297375|    4| 0.8213611|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|     pval|
|---------------:|---------:|--------:|
|      -0.0364932| 0.0362288| 0.387996|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001307|              0|TRUE                     |    0.2784806|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/EIF5AEpithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/EIF5AEpithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/EIF5AEpithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/EIF5AEpithelial_against_UKBb18436chunk8-1.png)
