

# Two sample MR report

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## SCPEP1_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    7| -0.0120252| 0.0344221| 0.7410611|
|Weighted median           |    7| -0.0311417| 0.0112974| 0.0058416|
|Inverse variance weighted |    7| -0.0266131| 0.0088359| 0.0025960|
|Simple mode               |    7| -0.0310929| 0.0176917| 0.1293439|
|Weighted mode             |    7| -0.0323567| 0.0157626| 0.0859137|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 2.950307|    5| 0.7076471|
|Inverse variance weighted | 3.142576|    6| 0.7907511|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0094488| 0.0215487| 0.6793327|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        9.59e-05|              0|TRUE                     |    0.3538242|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/SCPEP1Epithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/SCPEP1Epithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/SCPEP1Epithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/SCPEP1Epithelial_against_UKBb18436chunk8-1.png)
