

# Two sample MR report

---

## FAM110A_Interstitial Macrophages against UKB-b-18436

Date: **13 January, 2026**

---

### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    7| -0.0072573| 0.0647802| 0.9151580|
|Weighted median           |    7| -0.0247936| 0.0096828| 0.0104501|
|Inverse variance weighted |    7| -0.0203989| 0.0077663| 0.0086242|
|Simple mode               |    7| -0.0265581| 0.0133882| 0.0945388|
|Weighted mode             |    7| -0.0262615| 0.0143674| 0.1173361|

---

### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.589773|    5| 0.9024833|
|Inverse variance weighted | 1.631527|    6| 0.9502841|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0077255| 0.0378073| 0.8461462|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001593|              0|TRUE                     |    0.2307488|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/FAM110AInterstitial_Macrophages_against_UKBb18436chunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/FAM110AInterstitial_Macrophages_against_UKBb18436chunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/FAM110AInterstitial_Macrophages_against_UKBb18436chunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/FAM110AInterstitial_Macrophages_against_UKBb18436chunk8-1.png)
