

# Two sample MR report

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## FHAD1_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    9|  0.0258785| 0.0541245| 0.6471297|
|Weighted median           |    9| -0.0165492| 0.0073129| 0.0236346|
|Inverse variance weighted |    9| -0.0169342| 0.0058240| 0.0036416|
|Simple mode               |    9| -0.0158660| 0.0117208| 0.2128443|
|Weighted mode             |    9| -0.0157075| 0.0117716| 0.2188182|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 7.527743|    7| 0.3760699|
|Inverse variance weighted | 8.208866|    8| 0.4133381|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0305217| 0.0383512| 0.4522603|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0003451|              0|TRUE                     |    0.0778356|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/FHAD1Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/FHAD1Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/FHAD1Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/FHAD1Macrophages_against_UKBb18436chunk8-1.png)
