

# Two sample MR report

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## BTN3A2_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   12| 0.0894918| 0.1362436| 0.5261039|
|Weighted median           |   12| 0.0353539| 0.0075077| 0.0000025|
|Inverse variance weighted |   12| 0.0197293| 0.0096487| 0.0408783|
|Simple mode               |   12| 0.0357792| 0.0083313| 0.0012674|
|Weighted mode             |   12| 0.0357792| 0.0091022| 0.0023487|

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### Heterogeneity tests


|method                    |        Q| Q_df|   Q_pval|
|:-------------------------|--------:|----:|--------:|
|MR Egger                  | 39.31482|   10| 2.24e-05|
|Inverse variance weighted | 40.35118|   11| 3.11e-05|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|      -0.0721756| 0.140577| 0.6188067|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        8.94e-05|              0|TRUE                     |    0.3762946|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/BTN3A2Epithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/BTN3A2Epithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/BTN3A2Epithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/BTN3A2Epithelial_against_UKBb18436chunk8-1.png)
