

# Two sample MR report

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## THEMIS2_Mature NK T Cell against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    6| -0.0085100| 0.0556675| 0.8859006|
|Weighted median           |    6| -0.0119932| 0.0061847| 0.0524799|
|Inverse variance weighted |    6| -0.0124916| 0.0052476| 0.0172920|
|Simple mode               |    6| -0.0117206| 0.0083278| 0.2183290|
|Weighted mode             |    6| -0.0118158| 0.0081851| 0.2084580|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.1612538|    4| 0.9969192|
|Inverse variance weighted | 0.1664155|    5| 0.9994336|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0037723| 0.0525061| 0.9461746|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001172|              0|TRUE                     |    0.3031865|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/THEMIS2Mature_NK_T_Cell_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/THEMIS2Mature_NK_T_Cell_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/THEMIS2Mature_NK_T_Cell_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/THEMIS2Mature_NK_T_Cell_against_UKBb18436chunk8-1.png)
