

# Two sample MR report

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## HLA-DQA2_Monocyte (Mono) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   68| 0.0035722| 0.0084487| 0.6738030|
|Weighted median           |   68| 0.0125996| 0.0019064| 0.0000000|
|Inverse variance weighted |   68| 0.0100571| 0.0014504| 0.0000000|
|Simple mode               |   68| 0.0143807| 0.0036423| 0.0001915|
|Weighted mode             |   68| 0.0140765| 0.0039198| 0.0006224|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 84.10923|   66| 0.0657368|
|Inverse variance weighted | 84.88296|   67| 0.0691769|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0083068| 0.0106607| 0.4386524|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0023645|          1e-07|TRUE                     |        4e-06|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/HLADQA2Monocyte_Mono_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/HLADQA2Monocyte_Mono_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/HLADQA2Monocyte_Mono_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/HLADQA2Monocyte_Mono_against_UKBb18436chunk8-1.png)
