

# Two sample MR report

---

## ATF7IP2_Epithelial against bbj-a-88

Date: **13 January, 2026**

---

### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    7| 0.1489104| 0.3013925| 0.6421915|
|Weighted median           |    7| 0.0486284| 0.0246546| 0.0485653|
|Inverse variance weighted |    7| 0.0463299| 0.0202092| 0.0218758|
|Simple mode               |    7| 0.0469057| 0.0338208| 0.2148035|
|Weighted mode             |    7| 0.0421306| 0.0277279| 0.1794612|

---

### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.644860|    5| 0.8957719|
|Inverse variance weighted | 1.761225|    6| 0.9402974|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0448356| 0.1314353| 0.7468786|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|         8.1e-05|              0|TRUE                     |    0.3926761|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/ATF7IP2Epithelial_against_bbja88chunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/ATF7IP2Epithelial_against_bbja88chunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/ATF7IP2Epithelial_against_bbja88chunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/ATF7IP2Epithelial_against_bbja88chunk8-1.png)
