

# Two sample MR report

---

## WBSCR27_Monocyte (Mono) against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

---

### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    5| 0.0201859| 0.0795245| 0.8160273|
|Weighted median           |    5| 0.0666581| 0.0200401| 0.0008803|
|Inverse variance weighted |    5| 0.0640123| 0.0150935| 0.0000222|
|Simple mode               |    5| 0.0667308| 0.0253962| 0.0583333|
|Weighted mode             |    5| 0.0667874| 0.0251994| 0.0569603|

---

### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0079204|    3| 0.9998130|
|Inverse variance weighted | 0.3229866|    4| 0.9882824|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0478427| 0.0852344| 0.6137866|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        5.58e-05|              0|TRUE                     |    0.4830266|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/WBSCR27Monocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/WBSCR27Monocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/WBSCR27Monocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/WBSCR27Monocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
