

# Two sample MR report

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## DNAJB13_Epithelial against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   20| -0.0033582| 0.0318639| 0.9172303|
|Weighted median           |   20| -0.0235084| 0.0088709| 0.0080478|
|Inverse variance weighted |   20| -0.0219961| 0.0064773| 0.0006842|
|Simple mode               |   20| -0.0180868| 0.0154211| 0.2553460|
|Weighted mode             |   20| -0.0278625| 0.0149271| 0.0774733|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 13.37584|   18| 0.7687794|
|Inverse variance weighted | 13.73272|   19| 0.7990435|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0123337| 0.0206459| 0.5576854|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0005067|              0|TRUE                     |    0.0324735|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/DNAJB13Epithelial_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/DNAJB13Epithelial_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/DNAJB13Epithelial_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/DNAJB13Epithelial_against_bbja88chunk8-1.png)
