

# Two sample MR report

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## NUDT2_Epithelial against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    9| -0.0178238| 0.0665295| 0.7964932|
|Weighted median           |    9| -0.0308980| 0.0178135| 0.0828254|
|Inverse variance weighted |    9| -0.0329015| 0.0128998| 0.0107558|
|Simple mode               |    9| -0.0667616| 0.0237003| 0.0226012|
|Weighted mode             |    9| -0.0199321| 0.0193896| 0.3340347|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 5.706243|    7| 0.5744375|
|Inverse variance weighted | 5.759612|    8| 0.6741384|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0090788| 0.0392993| 0.8239093|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001786|              0|TRUE                     |    0.2049216|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/NUDT2Epithelial_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/NUDT2Epithelial_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/NUDT2Epithelial_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/NUDT2Epithelial_against_bbja88chunk8-1.png)
