

# Two sample MR report

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## POMZP3_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   13| -0.0755336| 0.0769876| 0.3476230|
|Weighted median           |   13| -0.0310244| 0.0086034| 0.0003108|
|Inverse variance weighted |   13| -0.0214261| 0.0072935| 0.0033064|
|Simple mode               |   13| -0.0387825| 0.0142612| 0.0186274|
|Weighted mode             |   13| -0.0362819| 0.0135979| 0.0204791|

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### Heterogeneity tests


|method                    |       Q| Q_df|    Q_pval|
|:-------------------------|-------:|----:|---------:|
|MR Egger                  | 16.5395|   11| 0.1222542|
|Inverse variance weighted | 17.2892|   12| 0.1390385|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0355112| 0.0502905| 0.4947962|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0002353|              0|TRUE                     |     0.146879|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/POMZP3Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/POMZP3Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/POMZP3Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/POMZP3Macrophages_against_UKBb18436chunk8-1.png)
