

# Two sample MR report

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## ERAP2_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   14| -0.0166676| 0.0751296| 0.8281601|
|Weighted median           |   14| -0.0502683| 0.0165568| 0.0023965|
|Inverse variance weighted |   14| -0.0400676| 0.0126158| 0.0014934|
|Simple mode               |   14| -0.0537955| 0.0264741| 0.0631093|
|Weighted mode             |   14| -0.0545458| 0.0228124| 0.0326264|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 5.073635|   12| 0.9554741|
|Inverse variance weighted | 5.173458|   13| 0.9711735|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0169033| 0.0535003| 0.7574702|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        0.001042|              0|TRUE                     |    0.0021262|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/ERAP2Macrophages_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/ERAP2Macrophages_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/ERAP2Macrophages_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/ERAP2Macrophages_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
