

# Two sample MR report

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## AKR1C1_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    4| 0.0357937| 0.0610317| 0.6169321|
|Weighted median           |    4| 0.0285447| 0.0090871| 0.0016823|
|Inverse variance weighted |    4| 0.0291676| 0.0080719| 0.0003021|
|Simple mode               |    4| 0.0263944| 0.0128681| 0.1326173|
|Weighted mode             |    4| 0.0265903| 0.0122483| 0.1183526|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.1398913|    2| 0.9324445|
|Inverse variance weighted | 0.1518880|    3| 0.9849547|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0075375| 0.0688175| 0.9227823|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        0.000107|              0|TRUE                     |    0.3278638|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/AKR1C1Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/AKR1C1Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/AKR1C1Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/AKR1C1Macrophages_against_UKBb18436chunk8-1.png)
