

# Two sample MR report

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## JAML_Alveolar Macrophages against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    6| 0.2624321| 0.1118544| 0.0788425|
|Weighted median           |    6| 0.0958683| 0.0200140| 0.0000017|
|Inverse variance weighted |    6| 0.0922819| 0.0140921| 0.0000000|
|Simple mode               |    6| 0.1225067| 0.0322084| 0.0125826|
|Weighted mode             |    6| 0.1216749| 0.0284416| 0.0078781|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 2.461190|    4| 0.6515986|
|Inverse variance weighted | 4.812488|    5| 0.4391905|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|      -0.1051387| 0.068566| 0.1999556|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001124|          1e-07|TRUE                     |     0.323225|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/JAMLAlveolar_Macrophages_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/JAMLAlveolar_Macrophages_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/JAMLAlveolar_Macrophages_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/JAMLAlveolar_Macrophages_against_bbja88chunk8-1.png)
