

# Two sample MR report

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## KANSL1-AS1_T Proliferating against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   56| 0.0275473| 0.0198735| 0.1714033|
|Weighted median           |   56| 0.0261174| 0.0033913| 0.0000000|
|Inverse variance weighted |   56| 0.0222123| 0.0026000| 0.0000000|
|Simple mode               |   56| 0.0263712| 0.0076894| 0.0011531|
|Weighted mode             |   56| 0.0262214| 0.0072012| 0.0006010|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 25.78513|   54| 0.9996005|
|Inverse variance weighted | 25.85845|   55| 0.9997193|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0039432| 0.0145626| 0.7875977|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0007615|              0|TRUE                     |    0.0088882|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/KANSL1AS1T_Proliferating_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/KANSL1AS1T_Proliferating_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/KANSL1AS1T_Proliferating_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/KANSL1AS1T_Proliferating_against_UKBb18436chunk8-1.png)
