

# Two sample MR report

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## CLEC12A_Monocyte (Mono) against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   13| -0.0156485| 0.1256776| 0.9031556|
|Weighted median           |   13| -0.0660639| 0.0240047| 0.0059210|
|Inverse variance weighted |   13| -0.0564297| 0.0194453| 0.0037082|
|Simple mode               |   13| -0.0681196| 0.0404378| 0.1178833|
|Weighted mode             |   13| -0.0669867| 0.0375751| 0.0999225|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 4.044648|   11| 0.9685927|
|Inverse variance weighted | 4.152525|   12| 0.9805241|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|     pval|
|---------------:|---------:|--------:|
|      -0.0205911| 0.0626924| 0.748742|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0003689|              0|TRUE                     |    0.0676848|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/CLEC12AMonocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/CLEC12AMonocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/CLEC12AMonocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/CLEC12AMonocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
