

# Two sample MR report

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## PTGR1_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    3| 0.2173609| 0.1653782| 0.4140617|
|Weighted median           |    3| 0.0567788| 0.0196786| 0.0039103|
|Inverse variance weighted |    3| 0.0509653| 0.0158084| 0.0012644|
|Simple mode               |    3| 0.0651233| 0.0256169| 0.1261171|
|Weighted mode             |    3| 0.0651233| 0.0267566| 0.1353615|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.1063994|    1| 0.7442812|
|Inverse variance weighted | 1.1280764|    2| 0.5689071|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.1451062| 0.1435586| 0.4965869|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        3.99e-05|              0|TRUE                     |    0.5534818|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/PTGR1Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/PTGR1Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/PTGR1Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/PTGR1Macrophages_against_UKBb18436chunk8-1.png)
