

# Two sample MR report

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## LY86_Alveolar Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    5| -0.0294038| 0.0438652| 0.5506388|
|Weighted median           |    5| -0.0344644| 0.0093499| 0.0002277|
|Inverse variance weighted |    5| -0.0350010| 0.0080885| 0.0000151|
|Simple mode               |    5| -0.0338749| 0.0120813| 0.0486173|
|Weighted mode             |    5| -0.0338749| 0.0117412| 0.0447808|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0511086|    3| 0.9969737|
|Inverse variance weighted | 0.0679634|    4| 0.9994355|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0042127| 0.0324485| 0.9049199|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0005141|              0|TRUE                     |    0.0315407|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/LY86Alveolar_Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/LY86Alveolar_Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/LY86Alveolar_Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/LY86Alveolar_Macrophages_against_UKBb18436chunk8-1.png)
