

# Two sample MR report

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## MRI1_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    3| 0.0101658| 0.1414351| 0.9543208|
|Weighted median           |    3| 0.0303834| 0.0142663| 0.0331938|
|Inverse variance weighted |    3| 0.0280276| 0.0117210| 0.0167917|
|Simple mode               |    3| 0.0351496| 0.0163464| 0.1645012|
|Weighted mode             |    3| 0.0339803| 0.0173472| 0.1892221|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.7953725|    1| 0.3724805|
|Inverse variance weighted | 0.8114319|    2| 0.6664995|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|       0.0106623| 0.084137| 0.9197515|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        4.14e-05|              0|TRUE                     |    0.5425915|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/MRI1Epithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/MRI1Epithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/MRI1Epithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/MRI1Epithelial_against_UKBb18436chunk8-1.png)
