

# Two sample MR report

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## GLB1L_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    4| -0.1260963| 0.2441528| 0.6569635|
|Weighted median           |    4| -0.0565457| 0.0316030| 0.0735750|
|Inverse variance weighted |    4| -0.0585778| 0.0273653| 0.0323077|
|Simple mode               |    4| -0.0463346| 0.0412066| 0.3426735|
|Weighted mode             |    4| -0.0475391| 0.0417014| 0.3370650|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.1952857|    2| 0.9069728|
|Inverse variance weighted | 0.2727342|    3| 0.9650721|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0548667| 0.1971524| 0.8069181|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        4.14e-05|              0|TRUE                     |    0.5414433|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/GLB1LMacrophages_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/GLB1LMacrophages_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/GLB1LMacrophages_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/GLB1LMacrophages_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
