

# Two sample MR report

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## CPNE1_Monocyte (Mono) against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   12| -0.2610146| 0.1181635| 0.0516543|
|Weighted median           |   12| -0.0884218| 0.0212794| 0.0000325|
|Inverse variance weighted |   12| -0.0605775| 0.0183397| 0.0009563|
|Simple mode               |   12| -0.0915008| 0.0309883| 0.0131445|
|Weighted mode             |   12| -0.0915008| 0.0276233| 0.0069233|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 12.01066|   10| 0.2843436|
|Inverse variance weighted | 15.53879|   11| 0.1591350|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.2027425| 0.1182922| 0.1173163|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0002065|              0|TRUE                     |    0.1747221|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/CPNE1Monocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/CPNE1Monocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/CPNE1Monocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/CPNE1Monocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
