

# Two sample MR report

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## CLEC10A_Epithelial against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|Weighted median           |    3| -0.0366401| 0.0135193| 0.0067241|
|Inverse variance weighted |    3| -0.0374872| 0.0111994| 0.0008162|
|Simple mode               |    3| -0.0358443| 0.0159066| 0.1529872|
|Weighted mode             |    3| -0.0358443| 0.0150415| 0.1400322|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|Inverse variance weighted | 0.0533461|    2| 0.9736795|

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### Test for directional horizontal pleiotropy


|egger_intercept |se |pval |
|:---------------|:--|:----|
|NA              |NA |NA   |

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        4.17e-05|              0|TRUE                     |     0.542045|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/CLEC10AEpithelial_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/CLEC10AEpithelial_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/CLEC10AEpithelial_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/CLEC10AEpithelial_against_bbja88chunk8-1.png)
