

# Two sample MR report

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## HLA-C_CD4+ T Cell against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3|  0.1669145| 0.1474012| 0.4605282|
|Weighted median           |    3| -0.0381272| 0.0201132| 0.0580085|
|Inverse variance weighted |    3| -0.0525777| 0.0159906| 0.0010089|
|Simple mode               |    3| -0.0319653| 0.0263805| 0.3493569|
|Weighted mode             |    3| -0.0319653| 0.0276295| 0.3668139|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0005746|    1| 0.9808754|
|Inverse variance weighted | 2.2414637|    2| 0.3260411|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.1774749| 0.1185569| 0.3749304|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        3.59e-05|              0|TRUE                     |    0.5756694|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/HLACCD4_T_Cell_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/HLACCD4_T_Cell_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/HLACCD4_T_Cell_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/HLACCD4_T_Cell_against_bbja88chunk8-1.png)
