

# Two sample MR report

---

## HLA-DQA1_Dendritic Cell (DC) against bbj-a-88

Date: **13 January, 2026**

---

### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    5|  0.1512878| 0.5301556| 0.7939325|
|Weighted median           |    5| -0.2735740| 0.0430806| 0.0000000|
|Inverse variance weighted |    5| -0.2888183| 0.0233954| 0.0000000|
|Simple mode               |    5| -0.2683866| 0.0496673| 0.0056783|
|Weighted mode             |    5| -0.2676137| 0.0549366| 0.0082119|

---

### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.131485|    3| 0.7694794|
|Inverse variance weighted | 1.821971|    4| 0.7684603|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.1515281| 0.1823543| 0.4669524|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        5.68e-05|          8e-07|TRUE                     |    0.5252762|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/HLADQA1Dendritic_Cell_DC_against_bbja88chunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/HLADQA1Dendritic_Cell_DC_against_bbja88chunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/HLADQA1Dendritic_Cell_DC_against_bbja88chunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/HLADQA1Dendritic_Cell_DC_against_bbja88chunk8-1.png)
