

# Two sample MR report

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## CBWD1_Monocyte (Mono) against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   16| -0.0672000| 0.1210334| 0.5875075|
|Weighted median           |   16| -0.1005612| 0.0158290| 0.0000000|
|Inverse variance weighted |   16| -0.0900818| 0.0117667| 0.0000000|
|Simple mode               |   16| -0.1047311| 0.0284796| 0.0022404|
|Weighted mode             |   16| -0.1038282| 0.0264849| 0.0013637|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  |  9.968765|   14| 0.7644635|
|Inverse variance weighted | 10.004847|   15| 0.8194349|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0160751| 0.0846263| 0.8520721|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0003813|          1e-07|TRUE                     |    0.0660942|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/CBWD1Monocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/CBWD1Monocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/CBWD1Monocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/CBWD1Monocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
