

# Two sample MR report

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## WAC-AS1_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3|  0.0320893| 0.1110701| 0.8209495|
|Weighted median           |    3| -0.0396511| 0.0209961| 0.0589595|
|Inverse variance weighted |    3| -0.0339496| 0.0162265| 0.0364173|
|Simple mode               |    3| -0.0411675| 0.0231114| 0.2168212|
|Weighted mode             |    3| -0.0412274| 0.0234632| 0.2209789|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0159217|    1| 0.8995886|
|Inverse variance weighted | 0.3771441|    2| 0.8281408|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|     pval|
|---------------:|---------:|--------:|
|      -0.0304879| 0.0507271| 0.655482|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        2.29e-05|              0|TRUE                     |    0.6505833|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/WACAS1Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/WACAS1Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/WACAS1Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/WACAS1Macrophages_against_UKBb18436chunk8-1.png)
