

# Two sample MR report

---

## LKAAEAR1_Epithelial against UKB-b-18436

Date: **13 January, 2026**

---

### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   16| -0.0456957| 0.0264414| 0.1059361|
|Weighted median           |   16| -0.0125152| 0.0044303| 0.0047292|
|Inverse variance weighted |   16| -0.0091013| 0.0034433| 0.0082129|
|Simple mode               |   16| -0.0129488| 0.0067994| 0.0762173|
|Weighted mode             |   16| -0.0133229| 0.0061621| 0.0471829|

---

### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 4.975548|   14| 0.9861501|
|Inverse variance weighted | 6.923995|   15| 0.9597246|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0329989| 0.0236404| 0.1844981|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0010914|              0|TRUE                     |    0.0016562|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/LKAAEAR1Epithelial_against_UKBb18436chunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/LKAAEAR1Epithelial_against_UKBb18436chunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/LKAAEAR1Epithelial_against_UKBb18436chunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/LKAAEAR1Epithelial_against_UKBb18436chunk8-1.png)
