

# Two sample MR report

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## TMEM176A_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   10|  0.1140270| 0.2873452| 0.7018692|
|Weighted median           |   10| -0.0254310| 0.0211898| 0.2300791|
|Inverse variance weighted |   10| -0.0413867| 0.0170630| 0.0152864|
|Simple mode               |   10| -0.0136436| 0.0356133| 0.7105354|
|Weighted mode             |   10| -0.0146047| 0.0346321| 0.6831314|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 4.381444|    8| 0.8211737|
|Inverse variance weighted | 4.675010|    9| 0.8616688|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0952087| 0.1757213| 0.6027042|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0003401|              0|TRUE                     |    0.0796415|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/TMEM176AMacrophages_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/TMEM176AMacrophages_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/TMEM176AMacrophages_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/TMEM176AMacrophages_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
