

# Two sample MR report

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## NQO2_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   14| 0.1586651| 0.0574353| 0.0171993|
|Weighted median           |   14| 0.0294408| 0.0077133| 0.0001351|
|Inverse variance weighted |   14| 0.0169522| 0.0070211| 0.0157584|
|Simple mode               |   14| 0.0342881| 0.0133684| 0.0235218|
|Weighted mode             |   14| 0.0339668| 0.0122400| 0.0157643|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 14.58823|   12| 0.2647306|
|Inverse variance weighted | 22.06915|   13| 0.0542996|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0969921| 0.0390994| 0.0289232|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0004943|              0|TRUE                     |     0.035264|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/NQO2Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/NQO2Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/NQO2Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/NQO2Macrophages_against_UKBb18436chunk8-1.png)
