

# Two sample MR report

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## TIMM10_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    5| -0.0561432| 0.1203500| 0.6726452|
|Weighted median           |    5|  0.0434722| 0.0289886| 0.1337092|
|Inverse variance weighted |    5|  0.0546598| 0.0245547| 0.0260112|
|Simple mode               |    5|  0.0416703| 0.0380565| 0.3350412|
|Weighted mode             |    5|  0.0403071| 0.0378625| 0.3470679|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.4443496|    3| 0.9309359|
|Inverse variance weighted | 1.3288051|    4| 0.8564697|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0779442| 0.0828792| 0.4163639|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001667|              0|TRUE                     |    0.2198917|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/TIMM10Macrophages_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/TIMM10Macrophages_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/TIMM10Macrophages_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/TIMM10Macrophages_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
