

# Two sample MR report

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## LDLRAD1_Epithelial against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    9| 0.0501369| 0.1423532| 0.7350529|
|Weighted median           |    9| 0.0257992| 0.0160628| 0.1082410|
|Inverse variance weighted |    9| 0.0292512| 0.0135340| 0.0306711|
|Simple mode               |    9| 0.0289619| 0.0253848| 0.2869052|
|Weighted mode             |    9| 0.0293739| 0.0217529| 0.2138611|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 3.817933|    7| 0.8004930|
|Inverse variance weighted | 3.839655|    8| 0.8712927|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0088133| 0.0597981| 0.8869835|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001486|              0|TRUE                     |    0.2468089|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/LDLRAD1Epithelial_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/LDLRAD1Epithelial_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/LDLRAD1Epithelial_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/LDLRAD1Epithelial_against_bbja88chunk8-1.png)
