

# Two sample MR report

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## CYBRD1_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    4| -0.0273341| 0.2028482| 0.9051458|
|Weighted median           |    4|  0.0482710| 0.0182305| 0.0081014|
|Inverse variance weighted |    4|  0.0423459| 0.0151017| 0.0050464|
|Simple mode               |    4|  0.0563315| 0.0264363| 0.1229136|
|Weighted mode             |    4|  0.0541723| 0.0262533| 0.1310619|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 2.099698|    2| 0.3499906|
|Inverse variance weighted | 2.224303|    3| 0.5271773|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0294939| 0.0856108| 0.7633151|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        3.24e-05|              0|TRUE                     |     0.591562|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/CYBRD1Epithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/CYBRD1Epithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/CYBRD1Epithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/CYBRD1Epithelial_against_UKBb18436chunk8-1.png)
