

# Two sample MR report

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## CECR1_Epithelial against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    5|  0.0249709| 0.1514446| 0.8795189|
|Weighted median           |    5| -0.0369951| 0.0152591| 0.0153310|
|Inverse variance weighted |    5| -0.0404258| 0.0128651| 0.0016764|
|Simple mode               |    5| -0.0371974| 0.0202858| 0.1406282|
|Weighted mode             |    5| -0.0371102| 0.0187522| 0.1189409|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.4791575|    3| 0.9234460|
|Inverse variance weighted | 0.6669807|    4| 0.9553376|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0503526| 0.1161841| 0.6940059|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0003715|              0|TRUE                     |    0.0673641|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/CECR1Epithelial_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/CECR1Epithelial_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/CECR1Epithelial_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/CECR1Epithelial_against_bbja88chunk8-1.png)
