

# Two sample MR report

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## HLA-DRB5_Monocyte (Mono) against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   27| 0.0949351| 0.0906136| 0.3048047|
|Weighted median           |   27| 0.0923430| 0.0226009| 0.0000439|
|Inverse variance weighted |   27| 0.0756131| 0.0174499| 0.0000147|
|Simple mode               |   27| 0.1033042| 0.0448491| 0.0295094|
|Weighted mode             |   27| 0.1006946| 0.0406426| 0.0200482|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 16.37676|   25| 0.9031461|
|Inverse variance weighted | 16.42398|   26| 0.9254554|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0077709| 0.0357609| 0.8297365|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0003681|              0|TRUE                     |    0.0689523|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/HLADRB5Monocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/HLADRB5Monocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/HLADRB5Monocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/HLADRB5Monocyte_Mono_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
