

# Two sample MR report

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## ABO_Epithelial against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    5|  0.0217698| 0.1328499| 0.8802531|
|Weighted median           |    5| -0.0405392| 0.0132545| 0.0022244|
|Inverse variance weighted |    5| -0.0338732| 0.0125047| 0.0067521|
|Simple mode               |    5| -0.0507107| 0.0228040| 0.0902343|
|Weighted mode             |    5| -0.0498836| 0.0244214| 0.1106141|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 5.954466|    3| 0.1138467|
|Inverse variance weighted | 6.306586|    4| 0.1773923|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0516666| 0.1226662| 0.7019676|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        8.06e-05|              0|TRUE                     |    0.3975582|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/ABOEpithelial_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/ABOEpithelial_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/ABOEpithelial_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/ABOEpithelial_against_bbja88chunk8-1.png)
