

# Two sample MR report

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## TMEM176A_Monocyte (Mono) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    9| 0.0761276| 0.0544208| 0.2045654|
|Weighted median           |    9| 0.0236199| 0.0093349| 0.0113974|
|Inverse variance weighted |    9| 0.0162171| 0.0073087| 0.0264964|
|Simple mode               |    9| 0.0255302| 0.0136787| 0.0989496|
|Weighted mode             |    9| 0.0255302| 0.0138786| 0.1031183|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 2.576741|    7| 0.9212084|
|Inverse variance weighted | 3.810930|    8| 0.8737663|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0341084| 0.0307022| 0.3032905|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001741|              0|TRUE                     |    0.2103607|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/TMEM176AMonocyte_Mono_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/TMEM176AMonocyte_Mono_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/TMEM176AMonocyte_Mono_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/TMEM176AMonocyte_Mono_against_UKBb18436chunk8-1.png)
