

# Two sample MR report

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## CBWD1_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    9|  0.0058637| 0.0351602| 0.8722655|
|Weighted median           |    9| -0.0120384| 0.0080651| 0.1355265|
|Inverse variance weighted |    9| -0.0133072| 0.0065758| 0.0430049|
|Simple mode               |    9| -0.0102234| 0.0121964| 0.4262341|
|Weighted mode             |    9| -0.0106931| 0.0107194| 0.3477118|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 2.787238|    7| 0.9039622|
|Inverse variance weighted | 3.095305|    8| 0.9282349|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0121107| 0.0218196| 0.5961508|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0006866|              0|TRUE                     |    0.0127056|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/CBWD1Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/CBWD1Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/CBWD1Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/CBWD1Macrophages_against_UKBb18436chunk8-1.png)
