

# Two sample MR report

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## PRUNE2_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   12| 0.0090601| 0.0713428| 0.9014625|
|Weighted median           |   12| 0.0382918| 0.0134309| 0.0043578|
|Inverse variance weighted |   12| 0.0328635| 0.0110798| 0.0030162|
|Simple mode               |   12| 0.0471470| 0.0218790| 0.0541831|
|Weighted mode             |   12| 0.0457578| 0.0229711| 0.0717840|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 2.519403|   10| 0.9905899|
|Inverse variance weighted | 2.633475|   11| 0.9947377|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0207399| 0.0614068| 0.7425376|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        0.000399|              0|TRUE                     |    0.0574003|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/PRUNE2Macrophages_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/PRUNE2Macrophages_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/PRUNE2Macrophages_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/PRUNE2Macrophages_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
