

# Two sample MR report

---

## BTN3A2_Macrophages against UKB-b-18436

Date: **13 January, 2026**

---

### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   32| 0.0182663| 0.0501511| 0.7182439|
|Weighted median           |   32| 0.0396941| 0.0053631| 0.0000000|
|Inverse variance weighted |   32| 0.0255831| 0.0065546| 0.0000950|
|Simple mode               |   32| 0.0417283| 0.0081103| 0.0000142|
|Weighted mode             |   32| 0.0414325| 0.0081092| 0.0000157|

---

### Heterogeneity tests


|method                    |        Q| Q_df| Q_pval|
|:-------------------------|--------:|----:|------:|
|MR Egger                  | 91.03490|   30|  0e+00|
|Inverse variance weighted | 91.10065|   31|  1e-07|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0060726| 0.0412549| 0.8839606|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0004575|          1e-07|TRUE                     |    0.0439809|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/BTN3A2Macrophages_against_UKBb18436chunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/BTN3A2Macrophages_against_UKBb18436chunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/BTN3A2Macrophages_against_UKBb18436chunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/BTN3A2Macrophages_against_UKBb18436chunk8-1.png)
