

# Two sample MR report

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## COMMD9_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3|  0.6529974| 3.8431687| 0.8928544|
|Weighted median           |    3| -0.1576701| 0.0693016| 0.0228981|
|Inverse variance weighted |    3| -0.1655831| 0.0542444| 0.0022692|
|Simple mode               |    3| -0.1534236| 0.0742011| 0.1745978|
|Weighted mode             |    3| -0.1535949| 0.0754314| 0.1786625|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0505825|    1| 0.8220527|
|Inverse variance weighted | 0.0959590|    2| 0.9531533|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|      -0.5115238| 2.401323| 0.8663859|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        2.13e-05|              0|TRUE                     |    0.6637281|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/COMMD9Macrophages_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/COMMD9Macrophages_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/COMMD9Macrophages_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/COMMD9Macrophages_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
