

# Two sample MR report

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## ELP5_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   14|  0.0577792| 0.0414523| 0.1886317|
|Weighted median           |   14| -0.0268710| 0.0068992| 0.0000983|
|Inverse variance weighted |   14| -0.0182577| 0.0050644| 0.0003120|
|Simple mode               |   14| -0.0280107| 0.0111470| 0.0259526|
|Weighted mode             |   14| -0.0280107| 0.0118605| 0.0344672|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  |  7.89151|   12| 0.7935500|
|Inverse variance weighted | 11.30723|   13| 0.5850973|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       -0.049192| 0.0266167| 0.0893613|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        0.000255|              0|TRUE                     |    0.1305204|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/ELP5Epithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/ELP5Epithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/ELP5Epithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/ELP5Epithelial_against_UKBb18436chunk8-1.png)
