

# Two sample MR report

---

## KANSL1_Epithelial against UKB-b-18436

Date: **13 January, 2026**

---

### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    8| 0.0140151| 0.1052893| 0.8984586|
|Weighted median           |    8| 0.0402438| 0.0129071| 0.0018210|
|Inverse variance weighted |    8| 0.0321546| 0.0102276| 0.0016671|
|Simple mode               |    8| 0.0418870| 0.0173570| 0.0465507|
|Weighted mode             |    8| 0.0415506| 0.0186913| 0.0616044|

---

### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 4.278925|    6| 0.6389871|
|Inverse variance weighted | 4.308889|    7| 0.7435910|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0090908| 0.0525173| 0.8682633|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        4.81e-05|              0|TRUE                     |    0.5118301|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/KANSL1Epithelial_against_UKBb18436chunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/KANSL1Epithelial_against_UKBb18436chunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/KANSL1Epithelial_against_UKBb18436chunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/KANSL1Epithelial_against_UKBb18436chunk8-1.png)
