

# Two sample MR report

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## GSTP1_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   19|  0.0198099| 0.0900296| 0.8284625|
|Weighted median           |   19| -0.0302877| 0.0115637| 0.0088139|
|Inverse variance weighted |   19| -0.0319863| 0.0089831| 0.0003698|
|Simple mode               |   19| -0.0306313| 0.0203802| 0.1501825|
|Weighted mode             |   19| -0.0290190| 0.0194029| 0.1520848|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 3.733994|   17| 0.9996764|
|Inverse variance weighted | 4.068320|   18| 0.9997317|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       -0.015999| 0.0276699| 0.5707036|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0004204|              0|TRUE                     |    0.0512197|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/GSTP1Epithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/GSTP1Epithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/GSTP1Epithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/GSTP1Epithelial_against_UKBb18436chunk8-1.png)
