

# Two sample MR report

---

## HLA-DQA2_T Proliferating against UKB-b-18436

Date: **13 January, 2026**

---

### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   30| -0.0042449| 0.0219538| 0.8480779|
|Weighted median           |   30|  0.0137474| 0.0040373| 0.0006613|
|Inverse variance weighted |   30|  0.0105205| 0.0027809| 0.0001548|
|Simple mode               |   30|  0.0165721| 0.0083348| 0.0562915|
|Weighted mode             |   30|  0.0163867| 0.0080329| 0.0505558|

---

### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 25.20507|   28| 0.6166519|
|Inverse variance weighted | 25.66479|   29| 0.6433421|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|        se|     pval|
|---------------:|---------:|--------:|
|       0.0130838| 0.0192969| 0.503321|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0004913|              0|TRUE                     |    0.0361928|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/HLADQA2T_Proliferating_against_UKBb18436chunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/HLADQA2T_Proliferating_against_UKBb18436chunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/HLADQA2T_Proliferating_against_UKBb18436chunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/HLADQA2T_Proliferating_against_UKBb18436chunk8-1.png)
