

# Two sample MR report

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## KANSL1-AS1_Dendritic Cell (DC) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   36| 0.0085986| 0.0344175| 0.8042214|
|Weighted median           |   36| 0.0227834| 0.0036895| 0.0000000|
|Inverse variance weighted |   36| 0.0191698| 0.0027729| 0.0000000|
|Simple mode               |   36| 0.0233129| 0.0070104| 0.0020807|
|Weighted mode             |   36| 0.0230803| 0.0068256| 0.0017864|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 18.83883|   34| 0.9835069|
|Inverse variance weighted | 18.93379|   35| 0.9877293|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|       0.0091468| 0.029683| 0.7598491|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0003417|              0|TRUE                     |    0.0799649|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/KANSL1AS1Dendritic_Cell_DC_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/KANSL1AS1Dendritic_Cell_DC_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/KANSL1AS1Dendritic_Cell_DC_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/KANSL1AS1Dendritic_Cell_DC_against_UKBb18436chunk8-1.png)
