

# Two sample MR report

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## ABHD12_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    4| -0.0162800| 0.1971803| 0.9417176|
|Weighted median           |    4| -0.0245149| 0.0135901| 0.0712509|
|Inverse variance weighted |    4| -0.0254597| 0.0110608| 0.0213469|
|Simple mode               |    4| -0.0233466| 0.0175354| 0.2751857|
|Weighted mode             |    4| -0.0228317| 0.0183929| 0.3026971|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.7636691|    2| 0.6826080|
|Inverse variance weighted | 0.7658433|    3| 0.8576182|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0049469| 0.1060932| 0.9670469|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|         4.4e-05|              0|TRUE                     |    0.5297942|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/ABHD12Epithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/ABHD12Epithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/ABHD12Epithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/ABHD12Epithelial_against_UKBb18436chunk8-1.png)
