

# Two sample MR report

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## HLA-DRB5_Dendritic Cell (DC) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   18| -0.2070536| 0.0620372| 0.0041753|
|Weighted median           |   18|  0.0455029| 0.0144087| 0.0015885|
|Inverse variance weighted |   18|  0.0389000| 0.0129017| 0.0025689|
|Simple mode               |   18|  0.0566979| 0.0287399| 0.0650079|
|Weighted mode             |   18|  0.0566979| 0.0324344| 0.0984855|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 19.64903|   16| 0.2364458|
|Inverse variance weighted | 39.40464|   17| 0.0015692|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.1004637| 0.0250481| 0.0010088|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0002628|              0|TRUE                     |    0.1271423|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/HLADRB5Dendritic_Cell_DC_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/HLADRB5Dendritic_Cell_DC_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/HLADRB5Dendritic_Cell_DC_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/HLADRB5Dendritic_Cell_DC_against_UKBb18436chunk8-1.png)
