

# Two sample MR report

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## LTBR_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3|  0.0866056| 1.9599802| 0.9718880|
|Weighted median           |    3| -0.1420139| 0.0550519| 0.0098905|
|Inverse variance weighted |    3| -0.1415457| 0.0457851| 0.0019913|
|Simple mode               |    3| -0.1438077| 0.0611364| 0.1429684|
|Weighted mode             |    3| -0.1433231| 0.0618603| 0.1464464|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0000061|    1| 0.9980354|
|Inverse variance weighted | 0.0135636|    2| 0.9932412|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.1057068| 0.9078485| 0.9262064|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        2.69e-05|              0|TRUE                     |    0.6247117|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/LTBRMacrophages_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/LTBRMacrophages_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/LTBRMacrophages_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/LTBRMacrophages_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
