

# Two sample MR report

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## C1orf141_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    7| 0.0030386| 0.0472693| 0.9512366|
|Weighted median           |    7| 0.0259305| 0.0104089| 0.0127320|
|Inverse variance weighted |    7| 0.0220809| 0.0079518| 0.0054891|
|Simple mode               |    7| 0.0302500| 0.0151291| 0.0924946|
|Weighted mode             |    7| 0.0298503| 0.0141975| 0.0802004|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.291288|    5| 0.9358256|
|Inverse variance weighted | 1.458300|    6| 0.9622163|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0120468| 0.0294779| 0.6996958|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0002167|              0|TRUE                     |    0.1622638|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/C1orf141Epithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/C1orf141Epithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/C1orf141Epithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/C1orf141Epithelial_against_UKBb18436chunk8-1.png)
