

# Two sample MR report

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## TOX_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    3| 0.9908030| 3.8388688| 0.8391992|
|Weighted median           |    3| 0.0337342| 0.0180100| 0.0610570|
|Inverse variance weighted |    3| 0.0312798| 0.0140362| 0.0258463|
|Simple mode               |    3| 0.0339693| 0.0198411| 0.2290156|
|Weighted mode             |    3| 0.0339693| 0.0191716| 0.2184283|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0126416|    1| 0.9104787|
|Inverse variance weighted | 0.0751171|    2| 0.9631380|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|     pval|
|---------------:|--------:|--------:|
|      -0.4837133| 1.935231| 0.844071|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        2.98e-05|              0|TRUE                     |    0.6048553|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/TOXEpithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/TOXEpithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/TOXEpithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/TOXEpithelial_against_UKBb18436chunk8-1.png)
