

# Two sample MR report

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## CST3_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    9|  0.0245403| 0.1217174| 0.8459497|
|Weighted median           |    9| -0.0414490| 0.0147547| 0.0049665|
|Inverse variance weighted |    9| -0.0409474| 0.0119823| 0.0006324|
|Simple mode               |    9| -0.0429750| 0.0213538| 0.0789688|
|Weighted mode             |    9| -0.0420435| 0.0194764| 0.0629178|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.1913348|    7| 0.9999784|
|Inverse variance weighted | 0.4836448|    8| 0.9998825|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|        -0.02737| 0.0506235| 0.6055121|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001168|              0|TRUE                     |    0.3049262|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/CST3Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/CST3Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/CST3Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/CST3Macrophages_against_UKBb18436chunk8-1.png)
