

# Two sample MR report

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## RPL13_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    7| 0.5130193| 1.4648413| 0.7404431|
|Weighted median           |    7| 0.4435994| 0.1338703| 0.0009209|
|Inverse variance weighted |    7| 0.4552671| 0.1056639| 0.0000164|
|Simple mode               |    7| 0.4399193| 0.1911488| 0.0609792|
|Weighted mode             |    7| 0.4399193| 0.1971018| 0.0670867|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.4949783|    5| 0.9923060|
|Inverse variance weighted | 0.4965408|    6| 0.9978803|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0104694| 0.2648573| 0.9699988|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001299|              0|TRUE                     |    0.2815324|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/RPL13Macrophages_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/RPL13Macrophages_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/RPL13Macrophages_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/RPL13Macrophages_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
