

# Two sample MR report

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## NEBL_Monocyte (Mono) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    4| 0.1164739| 0.0696465| 0.2364206|
|Weighted median           |    4| 0.0282224| 0.0097648| 0.0038499|
|Inverse variance weighted |    4| 0.0228007| 0.0074284| 0.0021449|
|Simple mode               |    4| 0.0296472| 0.0139455| 0.1234857|
|Weighted mode             |    4| 0.0296472| 0.0137754| 0.1204590|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.2700804|    2| 0.8736808|
|Inverse variance weighted | 2.0998670|    3| 0.5519397|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.1168921| 0.0864141| 0.3087854|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        2.87e-05|              0|TRUE                     |    0.6140209|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/NEBLMonocyte_Mono_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/NEBLMonocyte_Mono_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/NEBLMonocyte_Mono_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/NEBLMonocyte_Mono_against_UKBb18436chunk8-1.png)
