

# Two sample MR report

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## S100A13_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    4| 0.0254438| 0.3485706| 0.9484536|
|Weighted median           |    4| 0.0295336| 0.0139514| 0.0342686|
|Inverse variance weighted |    4| 0.0310734| 0.0125658| 0.0134040|
|Simple mode               |    4| 0.0253267| 0.0187653| 0.2699377|
|Weighted mode             |    4| 0.0253267| 0.0191089| 0.2769385|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.3075061|    2| 0.8574837|
|Inverse variance weighted | 0.3077673|    3| 0.9585611|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|        0.002632| 0.1628628| 0.9885731|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001651|              0|TRUE                     |    0.2223268|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/S100A13Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/S100A13Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/S100A13Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/S100A13Macrophages_against_UKBb18436chunk8-1.png)
