

# Two sample MR report

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## CDC42_Monocyte (Mono) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   10| -0.0388486| 0.0607694| 0.5405107|
|Weighted median           |   10| -0.0253819| 0.0100272| 0.0113639|
|Inverse variance weighted |   10| -0.0272285| 0.0081615| 0.0008493|
|Simple mode               |   10| -0.0239088| 0.0154180| 0.1553858|
|Weighted mode             |   10| -0.0243635| 0.0152090| 0.1436382|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.4655869|    8| 0.9998983|
|Inverse variance weighted | 0.5028218|    9| 0.9999688|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0064934| 0.0336509| 0.8517964|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001597|              0|TRUE                     |    0.2304408|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/CDC42Monocyte_Mono_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/CDC42Monocyte_Mono_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/CDC42Monocyte_Mono_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/CDC42Monocyte_Mono_against_UKBb18436chunk8-1.png)
