

# Two sample MR report

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## RRP7A_Dendritic Cell (DC) against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    7|  0.6882794| 0.4841585| 0.2144028|
|Weighted median           |    7| -0.1002636| 0.0295948| 0.0007043|
|Inverse variance weighted |    7| -0.0736157| 0.0329969| 0.0256821|
|Simple mode               |    7| -0.0990864| 0.0345243| 0.0284254|
|Weighted mode             |    7| -0.0990864| 0.0340204| 0.0268906|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  |  9.480805|    5| 0.0913561|
|Inverse variance weighted | 14.193947|    6| 0.0275431|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|     pval|
|---------------:|---------:|--------:|
|      -0.5209293| 0.3304161| 0.175715|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|         6.3e-05|              0|TRUE                     |    0.4552958|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/RRP7ADendritic_Cell_DC_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/RRP7ADendritic_Cell_DC_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/RRP7ADendritic_Cell_DC_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/RRP7ADendritic_Cell_DC_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
