

# Two sample MR report

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## KANSL1-AS1_Epithelial against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   62| 0.0078017| 0.0134660| 0.5645129|
|Weighted median           |   62| 0.0202049| 0.0026586| 0.0000000|
|Inverse variance weighted |   62| 0.0174134| 0.0019737| 0.0000000|
|Simple mode               |   62| 0.0211395| 0.0055572| 0.0003320|
|Weighted mode             |   62| 0.0208807| 0.0054925| 0.0003345|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 27.94949|   60| 0.9998683|
|Inverse variance weighted | 28.47015|   61| 0.9998795|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|        0.008996| 0.0124673| 0.4733615|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0018459|              0|TRUE                     |     4.45e-05|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/KANSL1AS1Epithelial_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/KANSL1AS1Epithelial_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/KANSL1AS1Epithelial_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/KANSL1AS1Epithelial_against_UKBb18436chunk8-1.png)
