

# Two sample MR report

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## SELENOW_Endothelial Cell (Endo) against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    5| -0.0519197| 0.3351148| 0.8867126|
|Weighted median           |    5| -0.1473962| 0.0369233| 0.0000655|
|Inverse variance weighted |    5| -0.1455693| 0.0307869| 0.0000023|
|Simple mode               |    5| -0.1571696| 0.0474154| 0.0295234|
|Weighted mode             |    5| -0.1325781| 0.0460272| 0.0449937|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.1279685|    3| 0.9882818|
|Inverse variance weighted | 0.2067285|    4| 0.9950122|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|     pval|
|---------------:|---------:|--------:|
|      -0.0428961| 0.1528496| 0.797226|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001781|              0|TRUE                     |    0.2071092|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/SELENOWEndothelial_Cell_Endo_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/SELENOWEndothelial_Cell_Endo_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/SELENOWEndothelial_Cell_Endo_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/SELENOWEndothelial_Cell_Endo_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
