

# Two sample MR report

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## ELP5_Alveolar Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    7|  0.0534940| 0.1489097| 0.7340898|
|Weighted median           |    7| -0.0250546| 0.0087819| 0.0043310|
|Inverse variance weighted |    7| -0.0262988| 0.0067870| 0.0001067|
|Simple mode               |    7| -0.0242371| 0.0116929| 0.0835620|
|Weighted mode             |    7| -0.0239818| 0.0114603| 0.0813066|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.1620248|    5| 0.9994694|
|Inverse variance weighted | 0.4497541|    6| 0.9983973|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|        -0.05335| 0.0994587| 0.6146757|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        0.000102|              0|TRUE                     |     0.338597|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/ELP5Alveolar_Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/ELP5Alveolar_Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/ELP5Alveolar_Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/ELP5Alveolar_Macrophages_against_UKBb18436chunk8-1.png)
