

# Two sample MR report

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## KANSL1-AS1_Monocyte (Mono) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   62| 0.0144647| 0.0181411| 0.4283944|
|Weighted median           |   62| 0.0208908| 0.0026762| 0.0000000|
|Inverse variance weighted |   62| 0.0186535| 0.0020239| 0.0000000|
|Simple mode               |   62| 0.0210035| 0.0056318| 0.0004228|
|Weighted mode             |   62| 0.0207535| 0.0052366| 0.0001965|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 24.75620|   60| 0.9999843|
|Inverse variance weighted | 24.81019|   61| 0.9999897|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|     pval|
|---------------:|---------:|--------:|
|       0.0038116| 0.0164044| 0.817056|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0024384|              0|TRUE                     |      2.7e-06|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/KANSL1AS1Monocyte_Mono_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/KANSL1AS1Monocyte_Mono_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/KANSL1AS1Monocyte_Mono_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/KANSL1AS1Monocyte_Mono_against_UKBb18436chunk8-1.png)
