

# Two sample MR report

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## RRP7A_Alveolar Macrophages against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    7|  0.5116602| 0.6461221| 0.4643167|
|Weighted median           |    7| -0.1022323| 0.0295946| 0.0005515|
|Inverse variance weighted |    7| -0.0726277| 0.0326037| 0.0259080|
|Simple mode               |    7| -0.1034368| 0.0362422| 0.0290275|
|Weighted mode             |    7| -0.1028296| 0.0355476| 0.0275950|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 11.77057|    5| 0.0380704|
|Inverse variance weighted | 13.70073|    6| 0.0331638|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|     pval|
|---------------:|---------:|--------:|
|      -0.3961217| 0.4374672| 0.406722|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        5.91e-05|              0|TRUE                     |    0.4694855|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/RRP7AAlveolar_Macrophages_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/RRP7AAlveolar_Macrophages_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/RRP7AAlveolar_Macrophages_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/RRP7AAlveolar_Macrophages_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
