

# Two sample MR report

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## SMDT1_Dendritic Cell (DC) against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    8| -0.2821456| 0.2667143| 0.3308394|
|Weighted median           |    8| -0.0592190| 0.0293417| 0.0435650|
|Inverse variance weighted |    8| -0.0526477| 0.0245471| 0.0319716|
|Simple mode               |    8| -0.0719972| 0.0448796| 0.1526979|
|Weighted mode             |    8| -0.0528990| 0.0425117| 0.2534207|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.667121|    6| 0.9476312|
|Inverse variance weighted | 2.413844|    7| 0.9334438|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.1081162| 0.1251155| 0.4207141|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        0.000353|              0|TRUE                     |    0.0737525|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/SMDT1Dendritic_Cell_DC_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/SMDT1Dendritic_Cell_DC_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/SMDT1Dendritic_Cell_DC_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/SMDT1Dendritic_Cell_DC_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
