

# Two sample MR report

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## CST3_Alveolar Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   10|  0.0089196| 0.0845385| 0.9185692|
|Weighted median           |   10| -0.0300565| 0.0101766| 0.0031421|
|Inverse variance weighted |   10| -0.0308227| 0.0083224| 0.0002126|
|Simple mode               |   10| -0.0297225| 0.0145240| 0.0710223|
|Weighted mode             |   10| -0.0299603| 0.0160287| 0.0944240|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.2622022|    8| 0.9999889|
|Inverse variance weighted | 0.4853681|    9| 0.9999732|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0225637| 0.0477636| 0.6492568|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0003777|              0|TRUE                     |    0.0645957|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/CST3Alveolar_Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/CST3Alveolar_Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/CST3Alveolar_Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/CST3Alveolar_Macrophages_against_UKBb18436chunk8-1.png)
