

# Two sample MR report

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## EIF5A_T Proliferating against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    4| 0.1655041| 0.1351228| 0.3453167|
|Weighted median           |    4| 0.0317273| 0.0142974| 0.0264799|
|Inverse variance weighted |    4| 0.0247481| 0.0124440| 0.0467277|
|Simple mode               |    4| 0.0341950| 0.0203570| 0.1915941|
|Weighted mode             |    4| 0.0345455| 0.0199649| 0.1820104|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.4459011|    2| 0.8001544|
|Inverse variance weighted | 1.5402997|    3| 0.6730009|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0691693| 0.0661189| 0.4052977|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        7.52e-05|              0|TRUE                     |    0.4107649|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/EIF5AT_Proliferating_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/EIF5AT_Proliferating_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/EIF5AT_Proliferating_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/EIF5AT_Proliferating_against_UKBb18436chunk8-1.png)
