

# Two sample MR report

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## RRP7A_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   15| -0.0076848| 0.0269766| 0.7802332|
|Weighted median           |   15| -0.0149007| 0.0079864| 0.0620758|
|Inverse variance weighted |   15| -0.0131022| 0.0058842| 0.0259682|
|Simple mode               |   15| -0.0149550| 0.0123533| 0.2460885|
|Weighted mode             |   15| -0.0147955| 0.0121055| 0.2418064|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 7.093267|   13| 0.8972813|
|Inverse variance weighted | 7.135611|   14| 0.9293576|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|     pval|
|---------------:|---------:|--------:|
|      -0.0040987| 0.0199185| 0.840154|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0005551|              0|TRUE                     |    0.0249257|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/RRP7AMacrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/RRP7AMacrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/RRP7AMacrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/RRP7AMacrophages_against_UKBb18436chunk8-1.png)
