

# Two sample MR report

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## HLA-A_Dendritic Cell (DC) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    6| -0.0140880| 0.1821423| 0.9420626|
|Weighted median           |    6|  0.0788096| 0.0189899| 0.0000332|
|Inverse variance weighted |    6|  0.0728686| 0.0137573| 0.0000001|
|Simple mode               |    6|  0.0846748| 0.0246873| 0.0186376|
|Weighted mode             |    6|  0.0829691| 0.0250363| 0.0211483|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.492350|    4| 0.8279957|
|Inverse variance weighted | 1.721578|    5| 0.8861702|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0315995| 0.0660004| 0.6570929|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|         8.6e-05|              0|TRUE                     |    0.3853639|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/HLAADendritic_Cell_DC_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/HLAADendritic_Cell_DC_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/HLAADendritic_Cell_DC_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/HLAADendritic_Cell_DC_against_UKBb18436chunk8-1.png)
