

# Two sample MR report

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## CDC42EP1_Interstitial Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    7| -0.1019550| 0.1622323| 0.5572956|
|Weighted median           |    7|  0.0246721| 0.0089164| 0.0056565|
|Inverse variance weighted |    7|  0.0226536| 0.0069809| 0.0011741|
|Simple mode               |    7|  0.0268992| 0.0132408| 0.0884755|
|Weighted mode             |    7|  0.0261374| 0.0126965| 0.0852179|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.357692|    5| 0.9288847|
|Inverse variance weighted | 1.948745|    6| 0.9243516|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|        0.082055| 0.1067314| 0.4767374|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        9.38e-05|              0|TRUE                     |    0.3588016|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/CDC42EP1Interstitial_Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/CDC42EP1Interstitial_Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/CDC42EP1Interstitial_Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/CDC42EP1Interstitial_Macrophages_against_UKBb18436chunk8-1.png)
