

# Two sample MR report

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## TDRD3_Interstitial Macrophages against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    6| -0.2898895| 0.3420155| 0.4444034|
|Weighted median           |    6| -0.0520719| 0.0239309| 0.0295605|
|Inverse variance weighted |    6| -0.0427632| 0.0190635| 0.0248838|
|Simple mode               |    6| -0.0523400| 0.0317893| 0.1605851|
|Weighted mode             |    6| -0.0526890| 0.0319435| 0.1599701|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 3.581990|    4| 0.4655215|
|Inverse variance weighted | 4.105709|    5| 0.5342991|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.2040012| 0.2818927| 0.5093173|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001123|              0|TRUE                     |    0.3143668|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/TDRD3Interstitial_Macrophages_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/TDRD3Interstitial_Macrophages_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/TDRD3Interstitial_Macrophages_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/TDRD3Interstitial_Macrophages_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
