

# Two sample MR report

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## HLA-A_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   37| -0.0507819| 0.0542407| 0.3555693|
|Weighted median           |   37|  0.0636929| 0.0077766| 0.0000000|
|Inverse variance weighted |   37|  0.0491574| 0.0058891| 0.0000000|
|Simple mode               |   37|  0.0684469| 0.0132252| 0.0000088|
|Weighted mode             |   37|  0.0680947| 0.0136225| 0.0000151|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 41.54025|   35| 0.2071520|
|Inverse variance weighted | 45.61448|   36| 0.1308139|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0396539| 0.0214025| 0.0723625|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0006671|          1e-07|TRUE                     |    0.0150707|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/HLAAMacrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/HLAAMacrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/HLAAMacrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/HLAAMacrophages_against_UKBb18436chunk8-1.png)
