

# Two sample MR report

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## KANSL1-AS1_Endothelial Cell (Endo) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   44| -0.0048115| 0.0149045| 0.7484321|
|Weighted median           |   44|  0.0149604| 0.0023131| 0.0000000|
|Inverse variance weighted |   44|  0.0133332| 0.0016328| 0.0000000|
|Simple mode               |   44|  0.0151220| 0.0044154| 0.0013637|
|Weighted mode             |   44|  0.0150393| 0.0043984| 0.0013857|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 16.53134|   42| 0.9998543|
|Inverse variance weighted | 18.03140|   43| 0.9997149|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0243053| 0.0198448| 0.2274875|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0007007|              0|TRUE                     |    0.0120793|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/KANSL1AS1Endothelial_Cell_Endo_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/KANSL1AS1Endothelial_Cell_Endo_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/KANSL1AS1Endothelial_Cell_Endo_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/KANSL1AS1Endothelial_Cell_Endo_against_UKBb18436chunk8-1.png)
