

# Two sample MR report

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## LGALS2_Interstitial Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    5| 0.0708512| 0.2274902| 0.7758494|
|Weighted median           |    5| 0.0201787| 0.0081341| 0.0131106|
|Inverse variance weighted |    5| 0.0201679| 0.0067229| 0.0027009|
|Simple mode               |    5| 0.0197524| 0.0105622| 0.1348150|
|Weighted mode             |    5| 0.0199030| 0.0101619| 0.1217512|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.3339809|    3| 0.9535159|
|Inverse variance weighted | 0.3836610|    4| 0.9837926|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0408042| 0.1830683| 0.8379344|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        7.36e-05|              0|TRUE                     |    0.4159689|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/LGALS2Interstitial_Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/LGALS2Interstitial_Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/LGALS2Interstitial_Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/LGALS2Interstitial_Macrophages_against_UKBb18436chunk8-1.png)
