

# Two sample MR report

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## IRF5_Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    8| 0.0611966| 0.1235865| 0.6380878|
|Weighted median           |    8| 0.0350009| 0.0132814| 0.0084056|
|Inverse variance weighted |    8| 0.0360912| 0.0109527| 0.0009836|
|Simple mode               |    8| 0.0298442| 0.0208760| 0.1959084|
|Weighted mode             |    8| 0.0295897| 0.0187879| 0.1592728|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.7143597|    6| 0.9941759|
|Inverse variance weighted | 0.7559523|    7| 0.9978679|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0097606| 0.0478594| 0.8451397|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001103|              0|TRUE                     |    0.3192339|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/IRF5Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/IRF5Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/IRF5Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/IRF5Macrophages_against_UKBb18436chunk8-1.png)
