

# Two sample MR report

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## GBP3_Endothelial Cell (Endo) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   22| -0.0278211| 0.0236384| 0.2530345|
|Weighted median           |   22| -0.0141888| 0.0039682| 0.0003495|
|Inverse variance weighted |   22| -0.0110738| 0.0031504| 0.0004396|
|Simple mode               |   22| -0.0155457| 0.0072828| 0.0447425|
|Weighted mode             |   22| -0.0162376| 0.0070898| 0.0324556|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  |  9.510673|   20| 0.9762023|
|Inverse variance weighted | 10.021694|   21| 0.9786288|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0144404| 0.0202004| 0.4829589|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0003818|              0|TRUE                     |    0.0632669|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/GBP3Endothelial_Cell_Endo_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/GBP3Endothelial_Cell_Endo_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/GBP3Endothelial_Cell_Endo_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/GBP3Endothelial_Cell_Endo_against_UKBb18436chunk8-1.png)
