

# Two sample MR report

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## RSPH4A_Smooth Muscle Cell (SMC) against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3| -0.0151947| 0.2208035| 0.9562596|
|Weighted median           |    3|  0.0256787| 0.0149040| 0.0848999|
|Inverse variance weighted |    3|  0.0253105| 0.0126599| 0.0455801|
|Simple mode               |    3|  0.0267309| 0.0164606| 0.2458760|
|Weighted mode             |    3|  0.0265858| 0.0169510| 0.2573338|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0041657|    1| 0.9485387|
|Inverse variance weighted | 0.0379286|    2| 0.9812144|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0374948| 0.2040568| 0.8843135|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        5.34e-05|              0|TRUE                     |    0.4875691|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/RSPH4ASmooth_Muscle_Cell_SMC_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/RSPH4ASmooth_Muscle_Cell_SMC_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/RSPH4ASmooth_Muscle_Cell_SMC_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/RSPH4ASmooth_Muscle_Cell_SMC_against_UKBb18436chunk8-1.png)
