

# Two sample MR report

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## HLA-A_T Proliferating against bbj-a-88

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    8|  0.0883386| 0.6283936| 0.8928037|
|Weighted median           |    8| -0.0326190| 0.0297981| 0.2736614|
|Inverse variance weighted |    8| -0.0809970| 0.0298045| 0.0065754|
|Simple mode               |    8| -0.0116819| 0.0500497| 0.8221243|
|Weighted mode             |    8| -0.0217737| 0.0451149| 0.6440865|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 19.85738|    6| 0.0029360|
|Inverse variance weighted | 20.09833|    7| 0.0053612|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0650091| 0.2409315| 0.7963359|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001831|          1e-07|TRUE                     |    0.2069208|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/HLAAT_Proliferating_against_bbja88chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/HLAAT_Proliferating_against_bbja88chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/HLAAT_Proliferating_against_bbja88chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/HLAAT_Proliferating_against_bbja88chunk8-1.png)
