

# Two sample MR report

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## MZT2A_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   10| 0.2818156| 0.3292895| 0.4169870|
|Weighted median           |   10| 0.1051761| 0.0277990| 0.0001547|
|Inverse variance weighted |   10| 0.0976458| 0.0212493| 0.0000043|
|Simple mode               |   10| 0.1121018| 0.0409624| 0.0229712|
|Weighted mode             |   10| 0.1093209| 0.0410237| 0.0258406|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 2.373376|    8| 0.9673743|
|Inverse variance weighted | 2.687494|    9| 0.9754088|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|      -0.0961799| 0.171608| 0.5905098|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001428|              0|TRUE                     |    0.2597781|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/MZT2AMacrophages_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/MZT2AMacrophages_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/MZT2AMacrophages_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/MZT2AMacrophages_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
