

# Two sample MR report

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## HLA-DQA1_Alveolar Macrophages against UKB-b-18436

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   22| -0.0055993| 0.0612654| 0.9280880|
|Weighted median           |   22|  0.0982587| 0.0085095| 0.0000000|
|Inverse variance weighted |   22|  0.0925888| 0.0057803| 0.0000000|
|Simple mode               |   22|  0.1076233| 0.0190031| 0.0000127|
|Weighted mode             |   22|  0.1062341| 0.0192171| 0.0000174|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 21.97713|   20| 0.3417530|
|Inverse variance weighted | 24.82314|   21| 0.2549052|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0539878| 0.0335465| 0.1232135|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0003586|          8e-07|TRUE                     |    0.0850195|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/HLADQA1Alveolar_Macrophages_against_UKBb18436chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/HLADQA1Alveolar_Macrophages_against_UKBb18436chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/HLADQA1Alveolar_Macrophages_against_UKBb18436chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/HLADQA1Alveolar_Macrophages_against_UKBb18436chunk8-1.png)
