

# Two sample MR report

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## TDRD3_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE

Date: **13 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   19|  0.0406162| 0.0859674| 0.6426063|
|Weighted median           |   19| -0.0640639| 0.0181954| 0.0004301|
|Inverse variance weighted |   19| -0.0495513| 0.0171104| 0.0037799|
|Simple mode               |   19| -0.0845537| 0.0306494| 0.0129290|
|Weighted mode             |   19| -0.0740475| 0.0305465| 0.0261018|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 34.00780|   17| 0.0083767|
|Inverse variance weighted | 36.29853|   18| 0.0064598|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0643454| 0.0601306| 0.2995354|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0005319|              0|TRUE                     |    0.0291942|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/TDRD3Macrophages_against_finnbASTHMAALLERGEXMOREchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/TDRD3Macrophages_against_finnbASTHMAALLERGEXMOREchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/TDRD3Macrophages_against_finnbASTHMAALLERGEXMOREchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/TDRD3Macrophages_against_finnbASTHMAALLERGEXMOREchunk8-1.png)
