Two sample MR report
AKR1C1_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 4 | 0.0357937 | 0.0610317 | 0.6169321 |
| Weighted median | 4 | 0.0285447 | 0.0090871 | 0.0016823 |
| Inverse variance weighted | 4 | 0.0291676 | 0.0080719 | 0.0003021 |
| Simple mode | 4 | 0.0263944 | 0.0128681 | 0.1326173 |
| Weighted mode | 4 | 0.0265903 | 0.0122483 | 0.1183526 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.1398913 | 2 | 0.9324445 |
| Inverse variance weighted | 0.1518880 | 3 | 0.9849547 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0075375 | 0.0688175 | 0.9227823 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.000107 | 0 | TRUE | 0.3278638 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
