Two sample MR report
AKR1C2_Epithelial against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 7 | 0.0437367 | 0.0469606 | 0.3944226 |
| Weighted median | 7 | 0.0297978 | 0.0100498 | 0.0030266 |
| Inverse variance weighted | 7 | 0.0227678 | 0.0091437 | 0.0127740 |
| Simple mode | 7 | 0.0304548 | 0.0132878 | 0.0617807 |
| Weighted mode | 7 | 0.0301691 | 0.0111299 | 0.0350769 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 7.748409 | 5 | 0.1706572 |
| Inverse variance weighted | 8.071495 | 6 | 0.2329120 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0192299 | 0.0421152 | 0.6671072 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001666 | 0 | TRUE | 0.2215121 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
