Two sample MR report
ANXA5_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 5 | 0.0206605 | 0.1353427 | 0.8883606 |
| Weighted median | 5 | 0.0443360 | 0.0182821 | 0.0153038 |
| Inverse variance weighted | 5 | 0.0490317 | 0.0152081 | 0.0012639 |
| Simple mode | 5 | 0.0448503 | 0.0232961 | 0.1265075 |
| Weighted mode | 5 | 0.0449496 | 0.0233976 | 0.1271071 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.5713729 | 3 | 0.9029535 |
| Inverse variance weighted | 0.6158771 | 4 | 0.9612831 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0107013 | 0.0507264 | 0.8464355 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 8.84e-05 | 0 | TRUE | 0.3742079 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
