Two sample MR report
APOL4_Epithelial against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 4 | -0.0207372 | 0.0430756 | 0.6777485 |
| Weighted median | 4 | -0.0116423 | 0.0064848 | 0.0726007 |
| Inverse variance weighted | 4 | -0.0114259 | 0.0056753 | 0.0440853 |
| Simple mode | 4 | -0.0127141 | 0.0088234 | 0.2452449 |
| Weighted mode | 4 | -0.0127141 | 0.0088520 | 0.2464440 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.4735724 | 2 | 0.7891600 |
| Inverse variance weighted | 0.5211233 | 3 | 0.9142268 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0106221 | 0.0487116 | 0.8476079 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001777 | 0 | TRUE | 0.2052265 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
