Two sample MR report
ATF7IP2_Epithelial against bbj-a-88
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 7 | 0.1489104 | 0.3013925 | 0.6421915 |
| Weighted median | 7 | 0.0486284 | 0.0246546 | 0.0485653 |
| Inverse variance weighted | 7 | 0.0463299 | 0.0202092 | 0.0218758 |
| Simple mode | 7 | 0.0469057 | 0.0338208 | 0.2148035 |
| Weighted mode | 7 | 0.0421306 | 0.0277279 | 0.1794612 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 1.644860 | 5 | 0.8957719 |
| Inverse variance weighted | 1.761225 | 6 | 0.9402974 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0448356 | 0.1314353 | 0.7468786 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 8.1e-05 | 0 | TRUE | 0.3926761 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
