Two sample MR report
BCL6_Epithelial against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | 0.1231813 | 0.1362900 | 0.4172028 |
| Weighted median | 6 | -0.0614613 | 0.0220845 | 0.0053858 |
| Inverse variance weighted | 6 | -0.0692082 | 0.0170581 | 0.0000497 |
| Simple mode | 6 | -0.0620126 | 0.0307449 | 0.0997510 |
| Weighted mode | 6 | -0.0613809 | 0.0302377 | 0.0981177 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.1891033 | 4 | 0.9958020 |
| Inverse variance weighted | 2.2134845 | 5 | 0.8188858 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0735545 | 0.0516967 | 0.2278725 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 5.07e-05 | 0 | TRUE | 0.5036324 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
