Two sample MR report
BTN3A2_Epithelial against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 12 | 0.0894918 | 0.1362436 | 0.5261039 |
| Weighted median | 12 | 0.0353539 | 0.0075077 | 0.0000025 |
| Inverse variance weighted | 12 | 0.0197293 | 0.0096487 | 0.0408783 |
| Simple mode | 12 | 0.0357792 | 0.0083313 | 0.0012674 |
| Weighted mode | 12 | 0.0357792 | 0.0091022 | 0.0023487 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 39.31482 | 10 | 2.24e-05 |
| Inverse variance weighted | 40.35118 | 11 | 3.11e-05 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0721756 | 0.140577 | 0.6188067 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 8.94e-05 | 0 | TRUE | 0.3762946 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
