Two sample MR report
BTN3A2_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 32 | 0.0182663 | 0.0501511 | 0.7182439 |
| Weighted median | 32 | 0.0396941 | 0.0053631 | 0.0000000 |
| Inverse variance weighted | 32 | 0.0255831 | 0.0065546 | 0.0000950 |
| Simple mode | 32 | 0.0417283 | 0.0081103 | 0.0000142 |
| Weighted mode | 32 | 0.0414325 | 0.0081092 | 0.0000157 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 91.03490 | 30 | 0e+00 |
| Inverse variance weighted | 91.10065 | 31 | 1e-07 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0060726 | 0.0412549 | 0.8839606 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0004575 | 1e-07 | TRUE | 0.0439809 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
