Two sample MR report
C10orf11_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 8 | 0.3676272 | 0.2629856 | 0.2116402 |
| Weighted median | 8 | 0.0502605 | 0.0297747 | 0.0914063 |
| Inverse variance weighted | 8 | 0.0723111 | 0.0230861 | 0.0017348 |
| Simple mode | 8 | 0.0448602 | 0.0426848 | 0.3281975 |
| Weighted mode | 8 | 0.0448602 | 0.0394987 | 0.2934508 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 2.325850 | 6 | 0.8874261 |
| Inverse variance weighted | 3.596629 | 7 | 0.8248872 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.1563691 | 0.1387126 | 0.302674 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001396 | 0 | TRUE | 0.2633507 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
