Two sample MR report
C1orf141_Epithelial against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 7 | 0.0030386 | 0.0472693 | 0.9512366 |
| Weighted median | 7 | 0.0259305 | 0.0104089 | 0.0127320 |
| Inverse variance weighted | 7 | 0.0220809 | 0.0079518 | 0.0054891 |
| Simple mode | 7 | 0.0302500 | 0.0151291 | 0.0924946 |
| Weighted mode | 7 | 0.0298503 | 0.0141975 | 0.0802004 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 1.291288 | 5 | 0.9358256 |
| Inverse variance weighted | 1.458300 | 6 | 0.9622163 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0120468 | 0.0294779 | 0.6996958 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0002167 | 0 | TRUE | 0.1622638 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
