Two sample MR report
C2orf74_Epithelial against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 20 | -0.0516233 | 0.0501560 | 0.3169928 |
| Weighted median | 20 | -0.0235366 | 0.0062204 | 0.0001545 |
| Inverse variance weighted | 20 | -0.0142561 | 0.0068984 | 0.0387741 |
| Simple mode | 20 | -0.0351706 | 0.0091667 | 0.0011124 |
| Weighted mode | 20 | -0.0313830 | 0.0080265 | 0.0009412 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 51.32253 | 18 | 4.75e-05 |
| Inverse variance weighted | 52.93637 | 19 | 4.79e-05 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0258249 | 0.0343263 | 0.4615743 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0005634 | 0 | TRUE | 0.0248169 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
