Two sample MR report
C4orf22_Epithelial against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 16 | -0.1412036 | 0.1062475 | 0.2050998 |
| Weighted median | 16 | 0.0110861 | 0.0126369 | 0.3803351 |
| Inverse variance weighted | 16 | 0.0177387 | 0.0089139 | 0.0465914 |
| Simple mode | 16 | 0.0459881 | 0.0223639 | 0.0575804 |
| Weighted mode | 16 | 0.0105682 | 0.0223601 | 0.6432776 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 13.11507 | 14 | 0.5174839 |
| Inverse variance weighted | 15.36845 | 15 | 0.4252170 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0647494 | 0.0431338 | 0.1555366 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001792 | 0 | TRUE | 0.2043851 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
