Two sample MR report
C4orf22_Epithelial against bbj-a-88
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 15 | 0.0358213 | 0.1366679 | 0.7973478 |
| Weighted median | 15 | -0.0392050 | 0.0149269 | 0.0086277 |
| Inverse variance weighted | 15 | -0.0314315 | 0.0114913 | 0.0062334 |
| Simple mode | 15 | -0.0380498 | 0.0230583 | 0.1211571 |
| Weighted mode | 15 | -0.0389949 | 0.0223186 | 0.1024936 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 5.456239 | 13 | 0.9637302 |
| Inverse variance weighted | 5.700115 | 14 | 0.9734933 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0273994 | 0.0554826 | 0.629659 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001811 | 0 | TRUE | 0.2012982 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
