Two sample MR report
CBWD1_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 9 | 0.0058637 | 0.0351602 | 0.8722655 |
| Weighted median | 9 | -0.0120384 | 0.0080651 | 0.1355265 |
| Inverse variance weighted | 9 | -0.0133072 | 0.0065758 | 0.0430049 |
| Simple mode | 9 | -0.0102234 | 0.0121964 | 0.4262341 |
| Weighted mode | 9 | -0.0106931 | 0.0107194 | 0.3477118 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 2.787238 | 7 | 0.9039622 |
| Inverse variance weighted | 3.095305 | 8 | 0.9282349 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0121107 | 0.0218196 | 0.5961508 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0006866 | 0 | TRUE | 0.0127056 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
