Two sample MR report
CD52_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | 0.1489065 | 0.1855860 | 0.4673078 |
| Weighted median | 6 | 0.0884159 | 0.0187218 | 0.0000023 |
| Inverse variance weighted | 6 | 0.0842328 | 0.0148675 | 0.0000000 |
| Simple mode | 6 | 0.0934838 | 0.0266972 | 0.0172544 |
| Weighted mode | 6 | 0.0934838 | 0.0283229 | 0.0214604 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.9467429 | 4 | 0.9177611 |
| Inverse variance weighted | 1.0689684 | 5 | 0.9568134 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0252425 | 0.0722025 | 0.7442636 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 4.21e-05 | 0 | TRUE | 0.5451598 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
