Two sample MR report
CDC42EP1_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 12 | 0.0307262 | 0.0294187 | 0.3208703 |
| Weighted median | 12 | 0.0166543 | 0.0053724 | 0.0019353 |
| Inverse variance weighted | 12 | 0.0159800 | 0.0043095 | 0.0002088 |
| Simple mode | 12 | 0.0158011 | 0.0082557 | 0.0819895 |
| Weighted mode | 12 | 0.0161616 | 0.0077826 | 0.0620568 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 2.918693 | 10 | 0.9832732 |
| Inverse variance weighted | 3.175455 | 11 | 0.9881979 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0123581 | 0.0243886 | 0.6233386 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0005778 | 0 | TRUE | 0.0222581 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
