Two sample MR report
CFD_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 14 | 0.0176823 | 0.0472512 | 0.7147703 |
| Weighted median | 14 | 0.0125080 | 0.0087441 | 0.1525883 |
| Inverse variance weighted | 14 | 0.0152117 | 0.0066102 | 0.0213784 |
| Simple mode | 14 | 0.0106018 | 0.0146080 | 0.4808512 |
| Weighted mode | 14 | 0.0104261 | 0.0152882 | 0.5072274 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 8.038281 | 12 | 0.7821318 |
| Inverse variance weighted | 8.041069 | 13 | 0.8409144 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.001413 | 0.0267596 | 0.9587561 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001832 | 0 | TRUE | 0.1990212 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
