Two sample MR report
CHD1L_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 18 | 0.0731246 | 0.0840540 | 0.3971799 |
| Weighted median | 18 | -0.0191862 | 0.0078728 | 0.0148081 |
| Inverse variance weighted | 18 | -0.0144179 | 0.0057887 | 0.0127484 |
| Simple mode | 18 | -0.0252651 | 0.0139480 | 0.0877884 |
| Weighted mode | 18 | -0.0252651 | 0.0137668 | 0.0840323 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 6.970157 | 16 | 0.9738320 |
| Inverse variance weighted | 8.060058 | 17 | 0.9652456 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0464233 | 0.0444675 | 0.3120109 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0003179 | 0 | TRUE | 0.0900162 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
