Two sample MR report
CLEC12A_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 15 | -0.1247409 | 0.1078021 | 0.2680398 |
| Weighted median | 15 | -0.0544848 | 0.0202417 | 0.0071088 |
| Inverse variance weighted | 15 | -0.0317098 | 0.0154884 | 0.0406266 |
| Simple mode | 15 | -0.0576241 | 0.0336448 | 0.1088123 |
| Weighted mode | 15 | -0.0572493 | 0.0317656 | 0.0930726 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 6.150565 | 13 | 0.9405010 |
| Inverse variance weighted | 6.910998 | 14 | 0.9380884 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0562093 | 0.0644582 | 0.3990127 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0006645 | 0 | TRUE | 0.0140991 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
