Two sample MR report
COMMD9_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | 0.6529974 | 3.8431687 | 0.8928544 |
| Weighted median | 3 | -0.1576701 | 0.0693016 | 0.0228981 |
| Inverse variance weighted | 3 | -0.1655831 | 0.0542444 | 0.0022692 |
| Simple mode | 3 | -0.1534236 | 0.0742011 | 0.1745978 |
| Weighted mode | 3 | -0.1535949 | 0.0754314 | 0.1786625 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0505825 | 1 | 0.8220527 |
| Inverse variance weighted | 0.0959590 | 2 | 0.9531533 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.5115238 | 2.401323 | 0.8663859 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 2.13e-05 | 0 | TRUE | 0.6637281 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
