Two sample MR report
CPNE1_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 10 | -0.0356789 | 0.3172919 | 0.9132383 |
| Weighted median | 10 | -0.0719775 | 0.0317944 | 0.0235836 |
| Inverse variance weighted | 10 | -0.0669112 | 0.0310625 | 0.0312336 |
| Simple mode | 10 | -0.1154876 | 0.0508634 | 0.0493193 |
| Weighted mode | 10 | -0.0949827 | 0.0475240 | 0.0767228 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 17.58089 | 8 | 0.0245977 |
| Inverse variance weighted | 17.60242 | 9 | 0.0400767 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0236685 | 0.2391527 | 0.9235985 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001379 | 0 | TRUE | 0.2678231 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
