Two sample MR report
CST3_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 9 | 0.0245403 | 0.1217174 | 0.8459497 |
| Weighted median | 9 | -0.0414490 | 0.0147547 | 0.0049665 |
| Inverse variance weighted | 9 | -0.0409474 | 0.0119823 | 0.0006324 |
| Simple mode | 9 | -0.0429750 | 0.0213538 | 0.0789688 |
| Weighted mode | 9 | -0.0420435 | 0.0194764 | 0.0629178 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.1913348 | 7 | 0.9999784 |
| Inverse variance weighted | 0.4836448 | 8 | 0.9998825 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.02737 | 0.0506235 | 0.6055121 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001168 | 0 | TRUE | 0.3049262 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
