Two sample MR report
CYBRD1_Epithelial against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 4 | -0.0273341 | 0.2028482 | 0.9051458 |
| Weighted median | 4 | 0.0482710 | 0.0182305 | 0.0081014 |
| Inverse variance weighted | 4 | 0.0423459 | 0.0151017 | 0.0050464 |
| Simple mode | 4 | 0.0563315 | 0.0264363 | 0.1229136 |
| Weighted mode | 4 | 0.0541723 | 0.0262533 | 0.1310619 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 2.099698 | 2 | 0.3499906 |
| Inverse variance weighted | 2.224303 | 3 | 0.5271773 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0294939 | 0.0856108 | 0.7633151 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 3.24e-05 | 0 | TRUE | 0.591562 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
