Two sample MR report
CYP4B1_Epithelial against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 10 | 0.0830016 | 0.0386893 | 0.0642400 |
| Weighted median | 10 | 0.0280177 | 0.0126451 | 0.0267124 |
| Inverse variance weighted | 10 | 0.0219160 | 0.0098895 | 0.0266858 |
| Simple mode | 10 | 0.0297051 | 0.0180119 | 0.1335092 |
| Weighted mode | 10 | 0.0302554 | 0.0178927 | 0.1251080 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 1.989354 | 8 | 0.9813365 |
| Inverse variance weighted | 4.656470 | 9 | 0.8631681 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0303478 | 0.0185826 | 0.1410841 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001313 | 0 | TRUE | 0.2761888 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
