Two sample MR report
DRAM2_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | -0.0617064 | 0.7413689 | 0.9471340 |
| Weighted median | 3 | 0.0564447 | 0.0200256 | 0.0048228 |
| Inverse variance weighted | 3 | 0.0552807 | 0.0162277 | 0.0006578 |
| Simple mode | 3 | 0.0572013 | 0.0236265 | 0.1365200 |
| Weighted mode | 3 | 0.0572013 | 0.0235924 | 0.1362027 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0005720 | 1 | 0.9809192 |
| Inverse variance weighted | 0.0254844 | 2 | 0.9873386 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0538072 | 0.3409047 | 0.9003402 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 2.49e-05 | 0 | TRUE | 0.6390772 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
