Two sample MR report
DRAM2_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | -0.1636505 | 1.9005110 | 0.9453164 |
| Weighted median | 3 | -0.1863260 | 0.0536345 | 0.0005128 |
| Inverse variance weighted | 3 | -0.1864989 | 0.0417036 | 0.0000077 |
| Simple mode | 3 | -0.1859606 | 0.0604068 | 0.0912986 |
| Weighted mode | 3 | -0.1860280 | 0.0597865 | 0.0896200 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0010587 | 1 | 0.9740431 |
| Inverse variance weighted | 0.0012033 | 2 | 0.9993985 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0105126 | 0.8742218 | 0.9923449 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 2.49e-05 | 0 | TRUE | 0.6423857 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
