Two sample MR report
DRC1_Epithelial against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 10 | -0.0697538 | 0.0615682 | 0.2900452 |
| Weighted median | 10 | -0.0217604 | 0.0119552 | 0.0687356 |
| Inverse variance weighted | 10 | -0.0228629 | 0.0096499 | 0.0178253 |
| Simple mode | 10 | -0.0326849 | 0.0186537 | 0.1136500 |
| Weighted mode | 10 | -0.0178969 | 0.0186737 | 0.3628974 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 1.917168 | 8 | 0.9834468 |
| Inverse variance weighted | 2.511824 | 9 | 0.9805638 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.029656 | 0.0384574 | 0.4627897 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001356 | 0 | TRUE | 0.2686315 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
