Two sample MR report
EIF5A_Epithelial against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 5 | 0.0986825 | 0.0758390 | 0.2841040 |
| Weighted median | 5 | 0.0265422 | 0.0138106 | 0.0546222 |
| Inverse variance weighted | 5 | 0.0231672 | 0.0114598 | 0.0432170 |
| Simple mode | 5 | 0.0263795 | 0.0187419 | 0.2320293 |
| Weighted mode | 5 | 0.0295591 | 0.0190629 | 0.1959329 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.5150906 | 3 | 0.9155638 |
| Inverse variance weighted | 1.5297375 | 4 | 0.8213611 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0364932 | 0.0362288 | 0.387996 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001307 | 0 | TRUE | 0.2784806 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
