Two sample MR report
ELP5_Epithelial against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 14 | 0.0577792 | 0.0414523 | 0.1886317 |
| Weighted median | 14 | -0.0268710 | 0.0068992 | 0.0000983 |
| Inverse variance weighted | 14 | -0.0182577 | 0.0050644 | 0.0003120 |
| Simple mode | 14 | -0.0280107 | 0.0111470 | 0.0259526 |
| Weighted mode | 14 | -0.0280107 | 0.0118605 | 0.0344672 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 7.89151 | 12 | 0.7935500 |
| Inverse variance weighted | 11.30723 | 13 | 0.5850973 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.049192 | 0.0266167 | 0.0893613 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.000255 | 0 | TRUE | 0.1305204 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
