Two sample MR report
ELP5_Epithelial against bbj-a-88
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 16 | 0.0319472 | 0.0588351 | 0.5956732 |
| Weighted median | 16 | 0.0421235 | 0.0087911 | 0.0000017 |
| Inverse variance weighted | 16 | 0.0437492 | 0.0068728 | 0.0000000 |
| Simple mode | 16 | 0.0413037 | 0.0133795 | 0.0075127 |
| Weighted mode | 16 | 0.0407026 | 0.0142011 | 0.0117751 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 1.333243 | 14 | 0.9999935 |
| Inverse variance weighted | 1.374038 | 15 | 0.9999977 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0074526 | 0.0368979 | 0.8428395 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0002891 | 0 | TRUE | 0.1077457 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
