Two sample MR report
ELP5_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 13 | -0.0073388 | 0.0310075 | 0.8172560 |
| Weighted median | 13 | -0.0190468 | 0.0053426 | 0.0003637 |
| Inverse variance weighted | 13 | -0.0188567 | 0.0042093 | 0.0000075 |
| Simple mode | 13 | -0.0186733 | 0.0080059 | 0.0379026 |
| Weighted mode | 13 | -0.0185463 | 0.0069216 | 0.0200560 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 5.322811 | 11 | 0.9145310 |
| Inverse variance weighted | 5.463378 | 12 | 0.9406874 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0094746 | 0.0252706 | 0.7148454 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0010881 | 0 | TRUE | 0.001718 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
