Two sample MR report
ELP5_Macrophages against bbj-a-88
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 15 | 0.0092672 | 0.0398832 | 0.8198772 |
| Weighted median | 15 | 0.0312395 | 0.0070114 | 0.0000084 |
| Inverse variance weighted | 15 | 0.0283005 | 0.0053953 | 0.0000002 |
| Simple mode | 15 | 0.0335193 | 0.0102948 | 0.0057444 |
| Weighted mode | 15 | 0.0307063 | 0.0100009 | 0.0083072 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 8.818984 | 13 | 0.7864733 |
| Inverse variance weighted | 9.050973 | 14 | 0.8277714 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0154786 | 0.0321365 | 0.6380599 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0012534 | 0 | TRUE | 0.0007673 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
