Two sample MR report
ERAP1_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 5 | -0.1044917 | 0.0969095 | 0.3598983 |
| Weighted median | 5 | -0.0594103 | 0.0171204 | 0.0005202 |
| Inverse variance weighted | 5 | -0.0564938 | 0.0137106 | 0.0000378 |
| Simple mode | 5 | -0.0625049 | 0.0222871 | 0.0485866 |
| Weighted mode | 5 | -0.0618205 | 0.0219742 | 0.0481539 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.2393576 | 3 | 0.9709986 |
| Inverse variance weighted | 0.4896768 | 4 | 0.9744981 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.024556 | 0.0490806 | 0.6512482 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 7.27e-05 | 0 | TRUE | 0.4213997 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
