Two sample MR report
ERAP2_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 14 | -0.0166676 | 0.0751296 | 0.8281601 |
| Weighted median | 14 | -0.0502683 | 0.0165568 | 0.0023965 |
| Inverse variance weighted | 14 | -0.0400676 | 0.0126158 | 0.0014934 |
| Simple mode | 14 | -0.0537955 | 0.0264741 | 0.0631093 |
| Weighted mode | 14 | -0.0545458 | 0.0228124 | 0.0326264 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 5.073635 | 12 | 0.9554741 |
| Inverse variance weighted | 5.173458 | 13 | 0.9711735 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0169033 | 0.0535003 | 0.7574702 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.001042 | 0 | TRUE | 0.0021262 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
