Two sample MR report
FAM3B_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | -0.0705124 | 0.0711870 | 0.5030311 |
| Weighted median | 3 | -0.0288835 | 0.0131068 | 0.0275449 |
| Inverse variance weighted | 3 | -0.0296799 | 0.0100999 | 0.0032967 |
| Simple mode | 3 | -0.0309592 | 0.0160219 | 0.1930349 |
| Weighted mode | 3 | -0.0264318 | 0.0161083 | 0.2425130 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.7637227 | 1 | 0.3821660 |
| Inverse variance weighted | 1.0994914 | 2 | 0.5770965 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0397446 | 0.0685896 | 0.6656624 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 5.63e-05 | 0 | TRUE | 0.4783544 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
