Two sample MR report
FXYD5_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 11 | -0.2085363 | 0.2396614 | 0.4068384 |
| Weighted median | 11 | -0.1372829 | 0.0387643 | 0.0003979 |
| Inverse variance weighted | 11 | -0.1049562 | 0.0290003 | 0.0002956 |
| Simple mode | 11 | -0.1435968 | 0.0561937 | 0.0285984 |
| Weighted mode | 11 | -0.1429466 | 0.0589417 | 0.0357413 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 6.206906 | 9 | 0.7190450 |
| Inverse variance weighted | 6.396473 | 10 | 0.7809265 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0368801 | 0.0847052 | 0.6735319 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001435 | 0 | TRUE | 0.256556 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
