Two sample MR report
GABPB1-AS1_Epithelial against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 4 | 0.0593457 | 0.1287996 | 0.6902204 |
| Weighted median | 4 | -0.0340662 | 0.0141623 | 0.0161541 |
| Inverse variance weighted | 4 | -0.0298118 | 0.0122658 | 0.0150787 |
| Simple mode | 4 | -0.0347365 | 0.0180522 | 0.1500145 |
| Weighted mode | 4 | -0.0345911 | 0.0185567 | 0.1591852 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0087475 | 2 | 0.9956358 |
| Inverse variance weighted | 0.4922996 | 3 | 0.9205799 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0442234 | 0.0635961 | 0.5587497 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001364 | 0 | TRUE | 0.2669975 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
